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Vaccination against Extracellular Vimentin for Treatment of Urothelial Cancer of the Bladder in Client-Owned Dogs
Cancers (Basel). 2023 Aug 3;15(15):3958. doi: 10.3390/cancers15153958.ABSTRACTIt was recently shown that targeting extracellular vimentin (eVim) is safe and effective in preclinical models. Here, we report the safety and efficacy in client-owned dogs with spontaneous bladder cancer of CVx1, an iBoost technology-based vaccine targeting eVim in combination with COX-2 inhibition. This was a single-arm prospective phase 1/2 study with CVx1 in 20 client-owned dogs with spontaneous UC which involved four subcutaneous vaccinations with CVx1 at 2-week intervals for induction of antibody titers, followed by maintenance vaccinations...
Source: Cancer Control - August 12, 2023 Category: Cancer & Oncology Authors: Diederik J M Engbersen Judy R van Beijnum Arno Roos Marit van Beelen Jan David de Haan Guy C M Grinwis Jack A Schalken J Alfred Witjes Arjan W Griffioen Elisabeth J M Huijbers Source Type: research

Age-dependent modulation of gut microbiome in response to tumor immunomodulation
In this study, we sequentially treated young mice (~8 weeks) and old mice (>18 months) with bilateral melanoma using FUS and calreticulin nanoparticles (CRT-NP) to enhance immunogenic cell death. The combination of CRT-NP and FUS (CFUS) demonstrated greater efficacy in inducing regression of treated and untreated tumors in young mice compared to old mice. The diminished effectiveness in older mice was associated with significant differences in gut microbiome composition, characterized by alterations in bacterial species and splenic immune cells. Specifically, young mice exposed to CFUS exhibited higher abundance of Bact...
Source: Experimental Gerontology - August 12, 2023 Category: Geriatrics Authors: Akansha Singh Harshini Ashar Ashish Ranjan Source Type: research

The most common gastrointestinal alterations in patients with post-COVID syndrome
CONCLUSION: We identified female gender, obesity, cardiovascular diseases, cancer, hypertension and diabetes as major risk factors of post-COVID syndrome. Vaccinated status may prevent post-COVID gastrointestinal symptoms. Orv Hetil. 2023; 164(31): 1206-1212.PMID:37543972 | DOI:10.1556/650.2023.32839
Source: Orvosi Hetilap - August 6, 2023 Category: General Medicine Authors: Kata Angyal Anna Mandula Tajthy B álint Drácz P ál Miheller Mikl ós Horváth Hajnal Sz ékely Veronika Papp Di ána Czompa Attila Szij ártó Kl ára Werling Source Type: research

SOGC Guideline Retirement Notice No. 3
J Obstet Gynaecol Can. 2022 Nov;44(11):1226-1236. doi: 10.1016/j.jogc.2022.09.005.ABSTRACTThese documents have been archived because they contain outdated information. They should not be consulted for clinical use, but for historical research only. Please visit the journal website for the most recent guidelines. Prenatal Screening for Fetal Aneuploidy [J Obstet Gynaecol Can 29 (2007) 146-161] AUTHORS Anne Summers, MD, North York, ON Sylvie Langlois, MD, Vancouver, BC Phil Wyatt, MD, PhD, Toronto, ON R. Douglas Wilson, MD, Philadelphia, PA A Report on Best Practices for Returning Birth to Rural and Remote Aboriginal Communi...
Source: Rural Remote Health - November 21, 2022 Category: Rural Health Source Type: research

Immunotheranostic microbubbles (iMBs) - a modular platform for dendritic cell vaccine delivery applied to breast cancer immunotherapy
CONCLUSION: These early findings strongly support the potential of DC-iMBs as a novel immunotherapeutic cell-free vaccine for anti-cancer therapy.PMID:36224614 | DOI:10.1186/s13046-022-02501-3
Source: Clinical Breast Cancer - October 12, 2022 Category: Cancer & Oncology Authors: Natacha Jugniot Jeremy J Dahl Ramasamy Paulmurugan Source Type: research

Experimental study on the induction of cytotoxic T lymphocyte killing effects and dendritic-cell-based tumor vaccine prepared by high-intensity focused ultrasound
CONCLUSIONS: HIFU prepared antigen-sensitized DC could cause substantial proliferation of T cells and CTL with strong anti-tumor effects. The DC-based tumor vaccine prepared using HIFU irradiation affected active immunization on the tumor occurrence in vitro and was better than the DC-based tumor vaccine prepared using the repeated-freezing-thawing method.PMID:36204875 | DOI:10.4103/jcrt.jcrt_2291_21
Source: Cancer Control - October 7, 2022 Category: Cancer & Oncology Authors: Zhichao Li Guoliang Xue Zhigang Wei Xin Ye Source Type: research

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