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Specialty: Allergy & Immunology
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Total 72221 results found since Jan 2013.
Overview of CD70 as a Potential Therapeutic Target for Osteosarcoma
J Immunol. 2023 Oct 1;211(7):1067-1072. doi: 10.4049/jimmunol.2200591.ABSTRACTOsteosarcoma is a primary malignant bone tumor. Effective chemotherapy regimens for refractory disease are scarce, accounting for no improvement in survival. Immune-based cell therapies have emerged as novel alternatives. However, advancements with these therapies have been seen mostly when immune cells are armed to target specific tumor Ags. Recent studies identified cluster of differentiation 70 (CD70) as a promising target to osteosarcoma particularly because CD70 is highly expressed in osteosarcoma lung metastases (Pahl et al. 2015. Cancer Ce...
Source: Journal of Immunology - September 18, 2023 Category: Allergy & Immunology Authors: Emily Rav Shinji Maegawa Vidya Gopalakrishnan Nancy Gordon Source Type: research
PD-1-Targeted Immunotherapy: The Ligand Matters
J Immunol. 2023 Oct 1;211(7):1065-1066. doi: 10.4049/jimmunol.2300239.NO ABSTRACTPMID:37722094 | DOI:10.4049/jimmunol.2300239
Source: Journal of Immunology - September 18, 2023 Category: Allergy & Immunology Authors: Andreas Wieland Mark P Rubinstein Zihai Li Source Type: research
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J Immunol. 2023 Oct 1;211(7):1063. doi: 10.4049/jimmunol.2390016.NO ABSTRACTPMID:37722093 | DOI:10.4049/jimmunol.2390016
Source: Journal of Immunology - September 18, 2023 Category: Allergy & Immunology Source Type: research
IFN- γ Limits Immunopathogenesis but Delays Fungal Clearance during Pneumocystis Pneumonia
J Immunol. 2023 Sep 18:ji2300460. doi: 10.4049/jimmunol.2300460. Online ahead of print.ABSTRACTHigh levels of IFN-γ are produced in the lung during an adaptive immune response to Pneumocystis, but the effects of this prototypical Th1 cytokine on fungal clearance and immunopathogenesis have not been fully defined. Therefore, Pneumocystis-infected immunodeficient mice were immune reconstituted and administered control or anti-IFN-γ neutralizing Ab to determine how IFN-γ regulates the balance between host defense and immune-mediated lung injury. Mice treated with anti-IFN-γ demonstrated an initial worsening of Pneumocysti...
Source: Journal of Immunology - September 18, 2023 Category: Allergy & Immunology Authors: Jing Wang Zhuo-Qian Zhang Francis Gigliotti Terry W Wright Source Type: research
Genetic Reduction of IRF5 Expression after Disease Initiation Reduces Disease in a Mouse Lupus Model by Impacting Systemic and End-Organ Pathogenic Pathways
In this study, we demonstrate that genetic reduction of IRF5 expression after disease initiation reduces disease severity in the FcγRIIB-/- Y-linked autoimmune accelerating mouse lupus model. Reduction of IRF5 expression resulted in a decrease in splenomegaly and lymphadenopathy and a reduction in splenic B cell activation and plasmablast numbers. Splenic T cell activation and differentiation were also impacted as demonstrated by an increase in the number of naive CD4+ and CD8+ T cells and a reduction in the number of memory/effector CD4+ and CD8+ T cells. Although serum antinuclear autoantibody levels were not altered, r...
Source: Journal of Immunology - September 18, 2023 Category: Allergy & Immunology Authors: Alex Pellerin Ying Tan Simon Lu Ramon G Bonegio Ian R Rifkin Source Type: research
Clinical features, risk factors, and outcomes of diffuse alveolar hemorrhage in antiphospholipid syndrome: A mixed-method approach combining a multicenter cohort with a systematic literature review
CONCLUSION: APS-associated DAH is associated with high morbidity and mortality, particularly when presenting with triple positivity, thrombocytopenia, valvular involvement, and CAPS.PMID:37722463 | DOI:10.1016/j.clim.2023.109775
Source: Clinical Immunology - September 18, 2023 Category: Allergy & Immunology Authors: Gabriel Figueroa-Parra Jose A Meade-Aguilar Hannah E Langenfeld Mariana Gonz ález-Treviño Mehmet Hocaoglu Andrew C Hanson Larry J Prokop M Hassan Murad Rodrigo Cartin-Ceba Ulrich Specks Vikas Majithia Cynthia S Crowson Al í Duarte-García Source Type: research
A newly developed PLD1 inhibitor ameliorates rheumatoid arthritis by regulating pathogenic T and B cells and inhibiting osteoclast differentiation
Immunol Lett. 2023 Sep 16:S0165-2478(23)00156-6. doi: 10.1016/j.imlet.2023.09.007. Online ahead of print.ABSTRACTPhospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline, plays multiple roles in inflammation. We investigated the therapeutic effects of the newly developed PLD1 inhibitors A2998, A3000, and A3773 in vitro and in vivo rheumatoid arthritis (RA) model. A3373 reduced the levels of LPS-induced TNF-α, IL-6, and IgG in murine splenocytes in vitro. A3373 also decreased the levels of IFN-γ and IL-17 and the frequencies of Th1, Th17 cells and germinal-center B ce...
Source: Immunology Letters - September 18, 2023 Category: Allergy & Immunology Authors: Jin-Sil Park SeungCheon Yang Doona Song Ha Yeon Jeong Sung-Min Kim JeongWon Choi Hye Yeon Kang Gyoonhee Han Do Sik Min Mi-La Cho Sung-Hwan Park Source Type: research
IFN- γ Limits Immunopathogenesis but Delays Fungal Clearance during Pneumocystis Pneumonia
J Immunol. 2023 Sep 18:ji2300460. doi: 10.4049/jimmunol.2300460. Online ahead of print.ABSTRACTHigh levels of IFN-γ are produced in the lung during an adaptive immune response to Pneumocystis, but the effects of this prototypical Th1 cytokine on fungal clearance and immunopathogenesis have not been fully defined. Therefore, Pneumocystis-infected immunodeficient mice were immune reconstituted and administered control or anti-IFN-γ neutralizing Ab to determine how IFN-γ regulates the balance between host defense and immune-mediated lung injury. Mice treated with anti-IFN-γ demonstrated an initial worsening of Pneumocysti...
Source: Journal of Immunology - September 18, 2023 Category: Allergy & Immunology Authors: Jing Wang Zhuo-Qian Zhang Francis Gigliotti Terry W Wright Source Type: research
Genetic Reduction of IRF5 Expression after Disease Initiation Reduces Disease in a Mouse Lupus Model by Impacting Systemic and End-Organ Pathogenic Pathways
In this study, we demonstrate that genetic reduction of IRF5 expression after disease initiation reduces disease severity in the FcγRIIB-/- Y-linked autoimmune accelerating mouse lupus model. Reduction of IRF5 expression resulted in a decrease in splenomegaly and lymphadenopathy and a reduction in splenic B cell activation and plasmablast numbers. Splenic T cell activation and differentiation were also impacted as demonstrated by an increase in the number of naive CD4+ and CD8+ T cells and a reduction in the number of memory/effector CD4+ and CD8+ T cells. Although serum antinuclear autoantibody levels were not altered, r...
Source: Journal of Immunology - September 18, 2023 Category: Allergy & Immunology Authors: Alex Pellerin Ying Tan Simon Lu Ramon G Bonegio Ian R Rifkin Source Type: research
Moderate and high-intensity interval training protect against diabetes-induced modulation of hepatic CD86 and CD206 expression associated with the amelioration of insulin resistance and inflammation in rats
Immunobiology. 2023 Sep 13;228(6):152745. doi: 10.1016/j.imbio.2023.152745. Online ahead of print.ABSTRACTDiabetes Mellitus (DM) can damage the function of metabolic tissues, including the liver. Liver macrophages are the first responders to tissue damage or exercise. We sought to determine whether eight weeks of interval training (HIIT & MIIT) protect against diabetes-induced modulation of hepatic CD86 and CD206 expression associated with the amelioration of insulin resistance and inflammation in rats. Thirty rats were divided into six groups, including a control group, MIIT, HIIT, DM, DM + MIIT, and DM + HIIT (n = 5 ...
Source: Immunobiology - September 18, 2023 Category: Allergy & Immunology Authors: Reza Sheikh Saeid Shakerian Seyed Reza Fatemi Tabatabaei Abdolhamid Habibi Source Type: research
Clinical features, risk factors, and outcomes of diffuse alveolar hemorrhage in antiphospholipid syndrome: A mixed-method approach combining a multicenter cohort with a systematic literature review
CONCLUSION: APS-associated DAH is associated with high morbidity and mortality, particularly when presenting with triple positivity, thrombocytopenia, valvular involvement, and CAPS.PMID:37722463 | DOI:10.1016/j.clim.2023.109775
Source: Clinical Immunology - September 18, 2023 Category: Allergy & Immunology Authors: Gabriel Figueroa-Parra Jose A Meade-Aguilar Hannah E Langenfeld Mariana Gonz ález-Treviño Mehmet Hocaoglu Andrew C Hanson Larry J Prokop M Hassan Murad Rodrigo Cartin-Ceba Ulrich Specks Vikas Majithia Cynthia S Crowson Al í Duarte-García Source Type: research
Digoxin protects against intervertebral disc degeneration via TNF/NF- κB and LRP4 signaling
ConclusionThese findings suggest that digoxin may be a potential therapeutic agent for intervertebral disc degeneration through anti-catabolism and pro-anabolism. Digoxin might also work as an alternative for other inflammation-related diseases.
Source: Frontiers in Immunology - September 18, 2023 Category: Allergy & Immunology Source Type: research
Deciphering the immunological and prognostic features of bladder cancer through platinum-resistance-related genes analysis and identifying potential therapeutic target P4HB
ConclusionOur study demonstrates that the PRR signatures are significantly associated with clinical-pathological features, the TIME, and prognostic features. The key PRR gene, P4HB, s a biomarker for the individualized treatment of BLCA patients.
Source: Frontiers in Immunology - September 18, 2023 Category: Allergy & Immunology Source Type: research
Autophagy and LC3-associated phagocytosis contribute negatively to the killing capability of THP-1-derived macrophages against Candida albicans at the mid-stage
Immunol Lett. 2023 Sep 15:S0165-2478(23)00155-4. doi: 10.1016/j.imlet.2023.09.006. Online ahead of print.ABSTRACTIn innate immunity, macrophages play critical roles in defending against pathogens via the lysosomal degradation function of autophagy. Two distinct autophagy pathways have been identified in decades: canonical autophagy (referred to as autophagy) and LC3-associated phagocytosis (LAP). Since several conflicting findings about the anti-Candida capability of autophagy (or LAP) have been reported, they serve as the foe or friend for Candida survival is still unclearly. The current study showed that the fungicidal p...
Source: Immunology Letters - September 17, 2023 Category: Allergy & Immunology Authors: Ding Li Lin Wang Zhihong Zhao Changsen Bai Xichuan Li Source Type: research
