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Pediatric continuous renal replacement: 20 years later
Conclusion After 20 years, significant developments in critical care nephrology have taken place. Clinical and technical issues have both been addressed, and severe pediatric AKI can currently be managed with accurate and safe dialysis machines that will likely warrant outcome improvements over the following decade.
Source: Intensive Care Medicine - April 17, 2015 Category: Intensive Care Source Type: research

First Dedicated Pediatric and Neonatal Acute Dialysis Machine Released U.S.
Medtronic is releasing in the United States the industry’s first and only dedicated pediatric and neonatal acute dialysis machine. The Carpediem (Cardio-Renal Pediatric Dialysis Emergency Machine) has been in development for about a decade a...
Source: Medgadget - December 10, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Cardiac Surgery Critical Care Medicine Pediatrics Urology medtronic Source Type: blogs

Outcomes of Critically Ill Children With Acute Lymphoblastic Leukemia and Cytokine Release Syndrome Due to Chimeric Antigen Receptor T Cell Therapy: US, Multicenter PICU, Cohort Database Study
CONCLUSIONS: PICU patients with CRS frequently received a high level of support, and the majority survived their PICU stay and hospitalization. Additional multicenter investigations of severe CRS are necessary to inform evidence-based practice.
Source: Pediatric Critical Care Medicine - December 1, 2022 Category: Pediatrics Tags: Online Brief Reports Source Type: research

Clinical Ethics and Inappropriate Care at ASBH 2018
In conclusion. patients assessed as receiving inappropriate critical care receive much burdensome and resource-intensive medical care, largely while non-alert, demonstrating the effects of mismatch between treatment and prognosis. Creeping Noninterference-Focused Autonomy in Modern Medicine: How We Created and Continue to Feed the Problem of FutilityCatherine S. Heith, MD The intersection of autonomy with modern-technologized and patient-satisfaction-driven medicine has had unexpected consequences. Although autonomy sprung from informed consent and the "right to die" movement, modern medicine, when paired with “ortho...
Source: blog.bioethics.net - September 29, 2018 Category: Medical Ethics Authors: Thaddeus Mason Pope, JD, PhD Tags: Health Care syndicated Source Type: blogs

The Evolution of Critical Care Nephrology in Edmonton
The University of Alberta (UofA) in Edmonton, Canada has a rich and productive history supporting the development of critical care medicine, nephrology and the evolving subspecialty of critical care nephrology. The first hemodialysis program for patients with chronic renal failure in Canada was developed at the University of Alberta Hospital. The UofA is also recognized for its early pioneering work on the diagnosis, etiology and outcomes associated with acute kidney injury (AKI), the development of a diagnostic scheme renal allograft rejection (Banff classification), and contributions to the Renal Disaster Relief Task For...
Source: Blood Purification - January 12, 2016 Category: Hematology Source Type: research

Choice of Catheter Size for Infants in Continuous Renal Replacement Therapy: Bigger Is Not Always Better*
Conclusions: Small size central vascular catheters display optimal rheologic performances in terms of pressures and flows particularly when the renal replacement therapy device is equipped with pumps proportional to central vascular catheters sizes, and even when relatively high blood flows are set. This is achieved at the risk of a higher hemolysis rate.
Source: Pediatric Critical Care Medicine - March 1, 2019 Category: Pediatrics Tags: Online Laboratory Investigation Source Type: research

Targeted Therapeutics for Critical Illnesses: Interview with Jason Springs, CEO of Endpoint Health
With the COVID-19 pandemic, critical illnesses, such as Acute Respiratory Distress Syndrome and sepsis are coming into the spotlight. Despite their severity and risk for patients, critical illnesses remain understudied and lack the number of treatmen...
Source: Medgadget - August 13, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Critical Care Exclusive Informatics Medicine Source Type: blogs

The Role of Therapeutic Plasma Exchange in the Treatment of Childhood Intoxication: A Single-Center Experience*
Conclusions: Therapeutic plasma exchange appears to be safe and effective for treating pediatric cases of intoxication, including multidrug and amitriptyline intoxication, and is associated with significant recovery in the majority of severely affected patients. Treatment of intoxication with therapeutic plasma exchange should be guided primarily by the properties of the causative toxic substances/drugs, and consideration of patient age, the severity of clinical symptoms, Pediatric Logistic Organ Dysfunction score and response to initial supportive and antidotal treatment.
Source: Pediatric Critical Care Medicine - November 1, 2020 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

Continuous Veno-Venous Hemodiafiltration and Plasma Exchange in Infantile Acute Liver Failure
Objectives: The purpose of the current study was to assess our multidisciplinary approach consisting of early application of neurology-oriented intensive care, aggressive artificial liver support and liver transplantation at the appropriate time for infants with acute liver failure. Design: Retrospective cohort study. Setting: A tertiary pediatric medical center in Japan. Patients: Seventeen infants younger than 12 months with acute liver failure who subsequently underwent liver transplantation between February 2006 and June 2011. Interventions: None. Measurements and Main Results: The patients varied from 1 to 11 months, ...
Source: Pediatric Critical Care Medicine - October 1, 2015 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

Perceived Barriers To Anthropometric Measurements In Critically Ill Children.
CONCLUSIONS: Barriers to obtaining anthropometric measurements exist in pediatric intensive care units; ordering providers and nurses have different perceptions of what constitutes a barrier. PMID: 26523018 [PubMed - in process]
Source: American Journal of Critical Care - November 1, 2015 Category: Nursing Authors: Irving SY, Seiple S, Nagle M, Falk S, Mascarenhas M, Srinivasan V Tags: Am J Crit Care Source Type: research

High-Volume Hemofiltration in Children With Acute Liver Failure*
Conclusions: High-volume hemofiltration therapy significantly improves hemodynamic stability and neurological status in children with acute liver failure awaiting for emergency liver transplantation.
Source: Pediatric Critical Care Medicine - September 1, 2014 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

Risk Factors of Acute Kidney Injury in Critically Ill Children*
Objectives: Acute kidney injury may be promoted by critical illness, preexisting medical conditions, and treatments received both before and during ICU admission. We aimed to estimate the frequency of acute kidney injury during ICU treatment and to determine factors, occurring both before and during the ICU stay, associated with the development of acute kidney injury. Design: Cohort study of critically ill children. Setting: University-affiliated PICU. Patients: Eligible patients were admitted to the ICU between January 2006 and June 2009. We excluded those admitted with known primary renal failure, chronic renal failur...
Source: Pediatric Critical Care Medicine - September 1, 2016 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

Circuit Lifetime With Citrate Versus Heparin in Pediatric Continuous Venovenous Hemodialysis*
Conclusions: We showed in our study that citrate provided significantly longer circuit lifetimes than heparin for continuous venovenous hemodialysis in children. Citrate was superior to heparin for the transfusion requirements. Citrate was feasible and safe in children and infants.
Source: Pediatric Critical Care Medicine - September 1, 2016 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

Continuous Venovenous Hemofiltration in Children Less Than or Equal to 10 kg: A Single-Center Experience
Conclusions: We have shown that continuous venovenous hemofiltration can be performed with good outcomes in children less than or equal to 10 kg using relatively high blood flow rates and with the current equipment available.
Source: Pediatric Critical Care Medicine - February 1, 2017 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

Renal Replacement Therapy Modalities in Critically Ill Children*
The objective of this study is to describe the relative frequency of use of continuous renal replacement therapy, intermittent hemodialysis, and peritoneal dialysis and to analyze characteristics and outcomes of critically ill children receiving renal replacement therapies admitted to PICUs that participate in the Virtual PICU (VPS LLC, Los Angeles, CA) registry. Design: Retrospective, database analysis. Setting: PICUs that participate in the Virtual PICU (VPS LLC) registry. Patients: Critically ill children admitted to PICUs that participate in the Virtual PICU (VPS LLC) registry and received renal replacement th...
Source: Pediatric Critical Care Medicine - January 1, 2019 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research