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Specialty: Cytology
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Total 78700 results found since Jan 2013.
Personalized Medicine's Coming of Age: One Drug, One Patient
Clin Cancer Res. 2023 Sep 21. doi: 10.1158/1078-0432.CCR-23-2194. Online ahead of print.ABSTRACTA dendritic cell/myeloma fusion vaccine, given with lenalidomide and GM-CSF, did not result in a statistically significant increase in CR rates at 1-year post-transplant but was associated with a significant increase in circulating multiple myeloma-reactive lymphocytes indicative of tumor-specific immunity.PMID:37733765 | DOI:10.1158/1078-0432.CCR-23-2194
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Muzaffar H Qazilbash Larry W Kwak Source Type: research
Identification of a TRP channel-related risk model for predicting prognosis and therapeutic effects of patients with hepatocellular carcinoma
CONCLUSIONS: We successfully established a highly accurate prognostic model for predicting overall survival and therapeutic effects using TRP channel-related genes.PMID:37733242 | DOI:10.1007/s00432-023-05394-7
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Chong Pang Zhe Xu Jilong Han Fujun Li Hongyan Zhu Jiaqi Zhang Dong Wang Xundi Xu Source Type: research
Integrated analysis of tumor microenvironment features to establish a diagnostic model for papillary thyroid cancer using bulk and single-cell RNA sequencing technology
CONCLUSIONS: Our study comprehensively characterized the tumor microenvironment in papillary thyroid cancer. Through combined analysis with bulk RNA-seq, six potential diagnostic biomarkers were identified and validated. The diagnostic model we constructed was a promising tool for PTC diagnosis. Our findings provide new insights into the heterogeneity of thyroid cancer and the theoretical basis for diagnosing thyroid cancer.PMID:37733241 | DOI:10.1007/s00432-023-05420-8
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Yizeng Wang Wenbin Song Yingxi Li Zhaoyi Liu Ke Zhao Lanning Jia Xiaoning Wang Ruoyu Jiang Yao Tian Xianghui He Source Type: research
CD4 levels and NSCLC metastasis: the benefits of maintaining moderate levels
CONCLUSIONS: A threshold effect is shown to exist between the peripheral blood CD4 and distant metastasis in NSCLC patients. It was revealed that the risk of distant metastasis is lower when CD4 is maintained between 32 and 44%, whereas low (< 32%) or high (> 44) levels of CD4 are associated with an increased risk of distant metastasis in NSCLC patients.PMID:37733240 | DOI:10.1007/s00432-023-05418-2
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Ying Bai Yafeng Liu Jing Wu Rui Miao Zhi Xu Chunxiao Hu Jiawei Zhou Jianqiang Guo Jun Xie Zilun Shi Xuansheng Ding Yingru Xing Dong Hu Source Type: research
Baseline interleukin-6 is a prognostic factor for patients with metastatic breast cancer treated with eribulin
CONCLUSION: Baseline IL-6 is an important prognostic factor in patients with MBC treated with eribulin. Our results show that high IL-6 is associated with higher levels of MDSCs which suppress anti-tumor immunity, such as CD8+ cells. It appears that eribulin is not particularly effective in patients with high IL-6 due to a poor tumor immune microenvironment.PMID:37733188 | DOI:10.1007/s10549-023-07086-9
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Ayako Bun Masayuki Nagahashi Mamiko Kuroiwa Miki Komatsu Yasuo Miyoshi Source Type: research
Eribulin promotes proliferation of CD8 < sup > + < /sup > T cells and potentiates T cell-mediated anti-tumor activity against triple-negative breast cancer cells
CONCLUSIONS: Eribulin promoted CD8+ T cell proliferation, repressed effector T cell differentiation, and harnessed T cell-mediated anti-tumor effects. These mechanisms may be one of the cues that eribulin can improve the immunological status of tumor-bearing hosts.PMID:37733186 | DOI:10.1007/s10549-023-07111-x
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Tadafumi Shimizu Takaaki Oba Masanori Oshi Ken-Ichi Ito Source Type: research
Diverse functions of myeloid-derived suppressor cells in autoimmune diseases
Immunol Res. 2023 Sep 21. doi: 10.1007/s12026-023-09421-0. Online ahead of print.ABSTRACTSince myeloid-derived suppressor cells (MDSCs) were found suppressing immune responses in cancer and other pathological conditions, subsequent researchers have pinned their hopes on the suppressive function against immune damage in autoimmune diseases. However, recent studies have found key distinctions of MDSC immune effects in cancer and autoimmunity. These include not only suppression and immune tolerance, but MDSCs also possess pro-inflammatory effects and exacerbate immune disorders during autoimmunity, while promoting T cell prol...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Xin Xiong Yang Zhang Yu Wen Source Type: research
Piperacetazine directly binds to the PAX3::FOXO1 fusion protein and inhibits its transcriptional activity
Cancer Res Commun. 2023 Sep 21. doi: 10.1158/2767-9764.CRC-23-0119. Online ahead of print.ABSTRACTThe tumor-specific chromosomal translocation product, PAX3::FOXO1, is an aberrant fusion protein that plays a key role for oncogenesis in the alveolar subtype of rhabdomyosarcoma (RMS). PAX3::FOXO1 represents a validated molecular target for alveolar RMS and successful inhibition of its oncogenic activity is likely to have significant clinical applications. Even though several PAX3::FOXO1 function-based screening studies have been successfully completed, a directly binding small molecule inhibitor of PAX3::FOXO1 has not been r...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Kay Nakazawa Taryn Shaw Young K Song Marilyn Kouassi-Brou Anna Molotkova Purushottam B Tiwari Hsien-Chao Chou Xinyu Wen Jun S Wei Emre Deniz Jeffrey Toretsky Charles Keller Frederic G Barr Javed Khan Aykut Üren Source Type: research
Chromatin accessibility landscape of human triple-negative breast cancer cell lines reveals variation by patient donor ancestry
Cancer Res Commun. 2023 Sep 21. doi: 10.1158/2767-9764.CRC-23-0236. Online ahead of print.ABSTRACTAfrican American (AA) women have an excessive risk of developing triple-negative breast cancer (TNBC). We employed ATAC-sequencing to characterize differences in chromatin accessibility between 9 commonly used TNBC cell lines derived from patients of European and African ancestry. Principal component and chromosome mapping analyses of accessibility peaks with the most variance revealed separation of chromatin profiles by patient group. Motif enrichment and footprinting analyses of disparate open chromatin regions revealed diff...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Alexandra R Harris Gatikrushna Panigrahi Huaitian Liu Vishal N Koparde Maeve Bailey-Whyte Tiffany H Dorsey Clayton C Yates Stefan Ambs Source Type: research
Role of inhibiting inflammation of LC3-associated phagocytosis in dry eye disease
CONCLUSION: DED increased the expression of protein associated to LAP. LAP could play an anti-inflammatory effect in DED.PMID:37732765 | DOI:10.1080/02713683.2023.2262169
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Sasa Zhang Xing Liu Cui Li Qian Wang Shanshan Yang Xudong Peng Liting Hu Guiqiu Zhao Jing Lin Source Type: research
Critical functions of extracellular matrix in brain metastasis seeding
Cell Mol Life Sci. 2023 Sep 20;80(10):297. doi: 10.1007/s00018-023-04944-z.ABSTRACTHuman brain is characterized by extremely sparse extracellular matrix (ECM). Despite its low abundance, the significance of brain ECM in both physiological and pathological conditions should not be underestimated. Brain metastasis is a serious complication of cancer, and recent findings highlighted the contribution of ECM in brain metastasis development. In this review, we provide a comprehensive outlook on how ECM proteins promote brain metastasis seeding. In particular, we discuss (1) disruption of the blood-brain barrier in brain metastas...
Source: Cellular and Molecular Life Sciences : CMLS - September 20, 2023 Category: Cytology Authors: Arseniy E Yuzhalin Dihua Yu Source Type: research
Human CD34 < sup > + < /sup > -derived complete plasmacytoid and conventional dendritic cell vaccine effectively induces antigen-specific CD8 < sup > + < /sup > T cell and NK cell responses in vitro and in vivo
In this study, we aimed to dissect the phenotypic identity of these non-DCs and their potential immune modulatory functions on the potency of cDCs and pDCs in stimulating tumor-reactive CD8+ T and NK cell responses, in order to obtain rationale for clinical translation of our DC-complete vaccine. The non-DC compartment was heterogeneous and comprised of myeloid progenitors and (immature) granulocyte- and monocyte-like cells. Importantly, non-DCs potentiated toll-like receptor-induced DC maturation, as reflected by increased expression of co-stimulatory molecules and enhanced cDC-derived IL-12 and pDC-derived IFN-α product...
Source: Cellular and Molecular Life Sciences : CMLS - September 20, 2023 Category: Cytology Authors: Jesper van Eck van der Sluijs Diede van Ens Jolanda Brummelman Daan Heister Aastha Sareen Lisa Truijen Dorette S van Ingen Schenau Mirjam H M Heemskerk Marieke Griffioen Michel G D Kester Nicolaas P M Schaap Joop H Jansen Anniek B van der Waart Harry Dols Source Type: research
Correction: Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion
Cell Mol Life Sci. 2023 Sep 20;80(10):296. doi: 10.1007/s00018-023-04942-1.NO ABSTRACTPMID:37728633 | DOI:10.1007/s00018-023-04942-1
Source: Cellular and Molecular Life Sciences : CMLS - September 20, 2023 Category: Cytology Authors: Sunil Yeruva Konstanze Stangner Anna Jungwirth Matthias Hiermaier Maria Shoykhet Daniela Kugelmann Michael Hertl Shohei Egami Norito Ishii Hiroshi Koga Takashi Hashimoto Michael Weis Britt-Maria Beckmann Ruth Biller Dominik Sch üttler Stefan K ääb Jens Source Type: research
Nrf2 and Ferroptosis: A New Research Direction for Ischemic Stroke
Cell Mol Neurobiol. 2023 Sep 20. doi: 10.1007/s10571-023-01411-y. Online ahead of print.ABSTRACTIschemic stroke (IS) is one of the leading causes of death and morbidity worldwide. As a novel form of cell death, ferroptosis is an important mechanism of ischemic stroke. Nuclear factor E2-related factor 2 (Nrf2) is the primary regulator of cellular antioxidant response. In addition to alleviating ischemic stroke nerve damage by reducing oxidative stress, Nrf2 regulates genes associated with ferroptosis, suggesting that Nrf2 may inhibit ferroptosis after ischemic stroke. However, the specific pathway of Nrf2 on ferroptosis in ...
Source: Cellular and Molecular Neurobiology - September 20, 2023 Category: Cytology Authors: Xiaoman Deng Wenming Chu Hanrui Zhang Yongjun Peng Source Type: research
ZNF746 promotes M2 macrophage polarisation and favours tumour progression in breast cancer via the Jagged1/Notch pathway
In conclusion, this study uncovers the role of ZNF746 in promoting M2 macrophage polarisation and suggests that ZNF746 may be a promising therapeutic target for limiting BC progression.PMID:37730102 | DOI:10.1016/j.cellsig.2023.110892
Source: Cellular Signalling - September 20, 2023 Category: Cytology Authors: Lu Liu Wen-Yue Zhao Xin-Yu Zheng Source Type: research
