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Procedure: Liver Transplant

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Total 21872 results found since Jan 2013.

Diarrhea in pediatric recipients of solid organ or bone marrow transplants
Diarrhea is common in adults after solid organ transplantation (SOT) and bone marrow transplantation (BMT), but data in children are limited. Therefore, we aimed to determine the incidence and etiology of pediatric early-onset diarrhea in post SOT and BMT. We reviewed children aged 6 months to 18 years who underwent liver transplantation, kidney transplantation or BMT between January 2015 and December 2019 with duration of diarrhea> 72 hours within the first 6 months after transplantation. Clinical data and diarrheal course were collected. Regression analyses were performed to define factors associated with the ...
Source: Medicine - October 29, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Heart rate variability is associated with encephalopathy and outcomes in pediatric acute liver failure
CONCLUSIONS: Heart rate variability may hold promise to predict outcomes in children with PALF, but these findings should be replicated in a larger sample.IMPACT: The findings of our study suggest that heart rate variability is associated with clinical outcomes in children with acute liver failure, a cohort for which prognostics are challenging, especially in young children and infants. Use of heart rate variability in the clinical setting may facilitate earlier detection of children with pediatric acute liver failure (PALF) at high risk for severe hepatic encephalopathy and poor outcomes. Identification of children with P...
Source: Pediatric Research - August 4, 2022 Category: Pediatrics Authors: Tricia R Pendergrast Catherine A Chapin Alyssa A Kriegermeier Andrea C Pardo Lee M Bass L Nelson Sanchez-Pinto Source Type: research

Advanced Sclerosis of The Chest Wall Skin Secondary to Chronic Graft-versus-Host Disease: A Case With Severe Restrictive Lung Defect
In conclusion, pulmonary cGvHD can present with restrictive changes related with the advanced sclerosis of the chest wall skin. Performing a fasciotomy or a scar revision for the rigid chest wall in selected patients may improve the patients ventilation.
Source: Journal of Pediatric Hematology Oncology - October 1, 2014 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research

Bedside to bench in juvenile myelomonocytic leukemia: insights into leukemogenesis from a rare pediatric leukemia
Juvenile myelomonocytic leukemia (JMML) is a typically aggressive myeloid neoplasm of childhood that is clinically characterized by overproduction of monocytic cells that can infiltrate organs, including the spleen, liver, gastrointestinal tract, and lung. JMML is categorized as an overlap myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN) by the World Health Organization and also shares some clinical and molecular features with chronic myelomonocytic leukemia, a similar disease in adults. Although the current standard of care for patients with JMML relies on allogeneic hematopoietic stem cell transplant, relap...
Source: Blood - October 16, 2014 Category: Hematology Authors: Chang, T. Y., Dvorak, C. C., Loh, M. L. Tags: Pediatric Hematology, Free Research Articles, Myeloid Neoplasia, Review Articles Source Type: research

Evaluation of the immune function assay in pediatric living donor liver transplantation
Abstract The immune function (ImmuKnow) assay is a measure of cell‐mediated immunity based on the peripheral CD4+ T cell ATP activity. The efficacy of ImmuKnow in pediatric LDLT is not well documented. The aim of this study was to assess the correlations between the ImmuKnow and the clinical status in pediatric LDLT recipients. A total of 716 blood samples were obtained from 60 pediatric LDLT recipients (one month to 16 yr of age). The recipient's status was classified as follows: stable, infection, or rejection. The ImmuKnow values in the pediatric LDLT recipients with a clinically stable status had a lower immune res...
Source: Pediatric Transplantation - November 24, 2014 Category: Transplant Surgery Authors: Akinari Fukuda, Ken‐Ichi Imadome, Seisuke Sakamoto, Takanobu Shigeta, Hajime Uchida, Masatoshi Matsunami, Kengo Sasaki, Hiroyuki Kanazawa, Fuyuko Kawano, Atsuko Nakazawa, Shigeyoshi Fujiwara, Mureo Kasahara Tags: Original Article Source Type: research

The Fashion Challenges of the Emperor of Hepatitis C Treatment - Now in the BMJ, but Who Will Notice?
As we wrote, most recently last week, the hepatitis C screening and treatment bandwagon keeps rolling along.  There is constant public argument whether about the prices of treatment regimens, which approach $100,000 per patient in the US.  However, nearly all the public chatter, which seems mostly to come from corporate public relations people and marketers, investors and investment advisers, physicians with financial conflicts of interest, and pundits with little background in clinical epidemiology, seems never to question the assumption that the new drugs for hepatitis C are miraculous cures, which, of course, ...
Source: Health Care Renewal - January 15, 2015 Category: Health Management Tags: clinical trials evidence-based medicine health care prices hepatitis C Sovaldi Source Type: blogs

Using pediatric liver grafts (≤6 yr) for adult recipients: A considerable option?
In this study, we included nine adult recipients (seven females and two males) who received grafts from children ≤6 yr from January 2008 to December 2013. We evaluated the graft quality, the GBWR and analyzed the recipients’ perioperative course. Laboratory samples and graft perfusion were analyzed. Nine adults with a median age of 49 yr (range: 25–65) and a median weight of 60 kg (range: 48–64) underwent LT with a pediatric donor graft. Median donor age was five yr (range: 3–6). Median GBWR was 1.02 (range: 0.86–1.45). After a median follow‐up of 3.9 yr (range: 11 months–6.6 yr), patient survival wa...
Source: Pediatric Transplantation - September 8, 2015 Category: Transplant Surgery Authors: Nagoud Schukfeh, Andreas Paul, Anja Gallinat, Dieter P. Hoyer, Jürgen W. Treckmann, Thomas Minor, Georgios C. Sotiropoulos, Martin L. Metzelder, Maren Schulze Tags: Original Article Source Type: research

Pediatric liver transplantation in Latin America: Where do we stand?
In conclusion, pediatric LT activity is growing in LA, especially in Brazil and Argentina. However, the lack of an appropriate LA registry restricts the assessment of quality and therefore restricts interventions aimed at quality improvements in different regions.
Source: Pediatric Transplantation - December 1, 2015 Category: Transplant Surgery Authors: Flavia Feier, Eduardo Antunes, Daniel D′Agostino, Gustavo Varela‐Fascinetto, Nicolas Jarufe, Juan C. Patillo, Alonso Vera, Felix Carrasco, Mario Kondo, Gilda Porta, Paulo Chapchap, Joao Seda‐Neto Tags: Original Article Source Type: research

Low Molecular Weight Heparin (LMWH) Prophylaxis to Prevent Sinusoidal Obstructive Syndrome (SOS) in Pediatric Hematopoietic Stem Cell Transplant (HSCT) Recipients
SOS of the liver following HSCT is characterized by endothelial damage resulting in obstruction of sinusoidal flow and small venule thrombosis (Carreras, BJH, 2014). Risk factors associated with its development are prior or currently elevated hepatic transaminases, history of hepatic radiation, hepatic fibrosis, second HSCT, busulfan use and disparate donors. Severe SOS is associated with a high mortality rate. Nieder et al previously reported from 38 COG HSCT centers an 11% incidence rate and 17% mortality rate in pediatric HSCT recipients (Nieder et al, ASBMT, 2007).
Source: Biology of Blood and Marrow Transplantation - February 19, 2016 Category: Hematology Authors: Zelda Ghersin, Lauren Harrison, Debra Abrams, Harshini Mahanti, Sandra Fabricatore, Liana Klejmont, Olga Militano, Carmella vandeVen, Mitchell S. Cairo Tags: Supportive Care and Nutrition Source Type: research

Bowel perforation after liver transplantation for biliary atresia: a retrospective study of care in the transition from children to adulthood
ConclusionThe clinical course after transplantation was complicated after adolescence. BPLT should be strongly suspected and relaparotomy should be performed in a timely manner for patients undergoing LT after adolescence.
Source: Pediatric Surgery International - November 22, 2016 Category: Surgery Source Type: research

Planning for the end of life: What baby Charlie can teach us
Charlie Gard was a one-year-old boy who had a rare genetic disease leaving him blind, comatose, and unable to breathe on his own. This metabolic disorder can be fatal and has no known cure. Charlie’s parents wanted him treated with experimental drugs in the hope that a miracle would happen. As reported in the press, the British medical and legal community considered this care futile and blocked it. This sad story created a flurry of public discussion about ethics, end of life care, and patient and parent autonomy. Experts debated the wisdom of the parents’ decision. The discussion centered on whether the experimental...
Source: Kevin, M.D. - Medical Weblog - August 20, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/mark-kelley" rel="tag" > Mark Kelley, MD < /a > Tags: Physician Critical Care Neurology Palliative Care Pediatrics Source Type: blogs

Trends in pediatric liver transplant donors and deceased donor circumstance of death in the United States, 2002 ‐2015
Abstract While much of the discussion regarding expanding the donor pool for pediatric liver transplantation has surrounded the use of technical variant grafts, little attention has been directed toward changes in the deceased donor population. The aim of this study was to investigate trends in the circumstance of the death of deceased donors used for pediatric liver transplantation. All pediatric liver transplant recipients transplanted between 2002 and 2015 were identified in the UNOS database and were categorized based on the donor circumstance of death. There was no significant correlation between year of transplantati...
Source: Pediatric Transplantation - January 30, 2018 Category: Transplant Surgery Authors: Dor Yoeli, Matthew Goss, Nhu. Thao N. Galv án, Moreshwar S. Desai, Tamir A. Miloh, Abbas Rana Tags: ORIGINAL ARTICLE Source Type: research

Primary care uniquely positions us to be our patients ’ best allies
My patient The day I met you was early in my second year of internal medicine residency. After much of my internship had been spent on arduous inpatient rotations, I was finally ready to lead my own team of young doctors and students on a high-acuity wards service. Yet, in my continuity clinic, I was still fresh, insecure, and naive. The day I met you, your abdomen was swollen, your eyes were yellow, you were drowsy and seemingly apathetic. Years of heavy alcohol use had sclerosed your liver, leading to hepatic disease in its final stages. You were my patient, I was your new primary care doctor — and I didn’t speak you...
Source: Kevin, M.D. - Medical Weblog - September 18, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/ashley-mcmullen" rel="tag" > Ashley McMullen, MD < /a > Tags: Physician Hospital-Based Medicine Source Type: blogs

Minimizing central line–associated bloodstream infections in a high-acuity liver transplant intensive care unit
ConclusionConcerted ongoing multidisciplinary collaboratives are essential to minimize CLABSI and optimize value and quality in a challenging, high-acuity patient population.
Source: American Journal of Infection Control - October 16, 2018 Category: Infectious Diseases Source Type: research