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Procedure: Liver Transplant

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Total 21872 results found since Jan 2013.

Long-term survival with growth hormone replacement after liver transplantation of pediatric nonalcoholic steatohepatitis complicating acquired hypopituitarism.
We describe here a pediatric patient with NASH associated with hypopituitarism who underwent living donor liver transplantation (LDLT). An 11-year-old boy was diagnosed with a pituitary tumor, which was removed by trans-interhemispheric approach following bifrontal craniotomy. Histopathological examination revealed a mature teratoma. Eighteen months later, magnetic resonance imaging showed recurrence of the pituitary tumor, which was found to be a germinoma. He underwent 3 months of chemoradiotherapy, with a complete response. He gradually became obese, with elevated transaminase levels. At age 15 years, he developed fatig...
Source: The Tohoku Journal of Experimental Medicine - March 8, 2015 Category: Research Authors: Fujio A, Kawagishi N, Echizenya T, Tokodai K, Nakanishi C, Miyagi S, Sato K, Fujimori K, Ohuchi N Tags: Tohoku J Exp Med Source Type: research

The Importance of Early Referral in Pediatric Acute Liver Failure.
CONCLUSIONS: Overall mortality was similar to the observed in other European centers. Liver transplantation is in fact the most effective therapeutic option. After 2008, there was a reduction in referral time and cases severity on admission; however, mortality has not reduced so far. PMID: 26667858 [PubMed - in process]
Source: Acta Medica Portuguesa - December 18, 2015 Category: Journals (General) Tags: Acta Med Port Source Type: research

Hepatic arterial and portal venous complications after adult and pediatric living donor liver transplantation, risk factors, management and outcome (A retrospective cohort study)
Conclusion HA and/or PV complications specially early ones lead to significant poor outcome after LDLT, so proper dealing with the risk factors like pre LT PVT (I.e. More intensive anticoagulation therapy) and the effective management of these complications are mandatory for improving outcome.
Source: Annals of Medicine and Surgery - May 29, 2016 Category: Journals (General) Source Type: research

Perioperative management of pediatric en‐bloc combined heart–liver transplants: a case series review
ConclusionCombined heart and liver transplantation in the pediatric population involves a complex group of patients with unique perioperative challenges. Successful management starts with thorough preoperative planning and communication and involves strategies to deal with massive intraoperative hemorrhage and coagulopathy in addition to protecting and supporting the transplanted heart and liver and meticulous surgical technique. An integrated multidisciplinary team approach is the cornerstone for successful outcomes.
Source: Pediatric Anesthesia - July 12, 2016 Category: Anesthesiology Authors: Manchula Navaratnam, Ann Ng, Glyn D. Williams, Katsuhide Maeda, Julianne M. Mendoza, Waldo Concepcion, Seth A. Hollander, Chandra Ramamoorthy Tags: Research Report Source Type: research

Perioperative management of pediatric en ‐bloc combined heart–liver transplants: a case series review
ConclusionCombined heart and liver transplantation in the pediatric population involves a complex group of patients with unique perioperative challenges. Successful management starts with thorough preoperative planning and communication and involves strategies to deal with massive intraoperative hemorrhage and coagulopathy in addition to protecting and supporting the transplanted heart and liver and meticulous surgical technique. An integrated multidisciplinary team approach is the cornerstone for successful outcomes.
Source: Pediatric Anesthesia - July 21, 2016 Category: Anesthesiology Authors: Manchula Navaratnam, Ann Ng, Glyn D. Williams, Katsuhide Maeda, Julianne M. Mendoza, Waldo Concepcion, Seth A. Hollander, Chandra Ramamoorthy Tags: Research Report Source Type: research

Pediatric living-donor liver transplantation
Living donor liver transplantation is an important component of all liver transplant programs especially in those that care for the pediatric population. Over the last thirty years, innovations in surgical technique have converted living donation from an experimental procedure to a standard of care. Many of these innovations occurred in countries where culturally, deceased donation is limited leaving no alternatives but living donation. The Organ Transplantation Center at the National Center for Child Health and Development (NCCHD) in Tokyo, Japan, was established in 2005 where we have generated some of those innovations a...
Source: Seminars in Pediatric Surgery - July 26, 2017 Category: Pediatrics Authors: Mureo Kasahara, Seisuke Sakamoto, Akinari Fukuda Source Type: research

Extubation in the operating room after pediatric liver transplant: A retrospective cohort study
ConclusionMore than half of our pediatric liver transplant patients were successfully extubated in the operating room immediately following surgery. We believe early extubation to be safe when employed in selected subpopulations of pediatric patients undergoing liver transplantation.
Source: Pediatric Anesthesia - January 1, 2018 Category: Anesthesiology Authors: Harshad G. Gurnaney, Scott D. Cook ‐Sather, Abraham Shaked, Kim M. Olthoff, Elizabeth B. Rand, Arul M. Lingappan, Mohamed A. Rehman Tags: RESEARCH REPORT Source Type: research

Role of interventional radiology in managing pediatric liver tumors
AbstractPrimary liver malignancies are rare in children. Hepatoblastoma and hepatocellular carcinoma (HCC) together represent the overwhelming majority of cases. Overall survival of hepatoblastoma approaches 80% with multimodal treatment approaches that include chemotherapy, surgery and transplantation. However, there remains a subset of children with hepatoblastoma in whom resection or transplantation is not possible. The 5-year survival for children diagnosed with HCC is less than 30% and remains a significant therapeutic challenge. The poor outcomes for children with primary liver tumors motivate investigation of new th...
Source: Pediatric Radiology - January 23, 2018 Category: Radiology Source Type: research

Diet and Exercise in Pediatric Liver Transplant Recipients: Behaviors and Association With Metabolic Syndrome
Conclusions: Additional counseling during routine post-LT care on the importance of physical activity and healthy diet may be useful. However, it is unlikely that these factors alone explain the increased prevalence of metabolic syndrome components in pediatric LT recipients.
Source: Journal of Pediatric Gastroenterology and Nutrition - December 29, 2018 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Long-term Outcomes and Health Perceptions in Pediatric-onset Portal Hypertension Complicated by Varices
Conclusions: Pediatric-onset portal hypertension is a heterogeneous disease with significant long-term morbidity, requiring multimodal approach with considerable resources and continuation of follow-up in adulthood. Although mortality to variceal bleeding was avoided, bleeding episodes recurred also in adulthood, while patient-reported health of long-term survivors was encouraging.
Source: Journal of Pediatric Gastroenterology and Nutrition - April 27, 2020 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Education and Psychosocial Factors Predict Odds of Death After Transfer to Adult health Care in Pediatric Liver Transplant Patients
Objectives: To analyze demographic, psychosocial, and clinical factors in pediatric liver transplant recipients for their association with death or loss to follow up in adulthood. We aimed to better understand known health disparities in transplant outcomes and identify potentially modifiable risk factors prior to transfer. Methods: A retrospective cohort study of children who underwent liver transplantation at a large tertiary transplant center and were transferred to adult care between 2000 and 2015. Results: During the study period, 101 qualifying patients were transferred. Ninety-three individuals fol...
Source: Journal of Pediatric Gastroenterology and Nutrition - November 1, 2022 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Liver transplantation in cystic fibrosis: A report from Baylor College of Medicine and the Texas Children's Hospital
We report the outcomes of OLT for pediatric patients with CFLD from the largest children's hospital in the United States. Our records since September 1998 were analyzed for all patients undergoing OLT for CFLD. Nine patients were then compared to similar patients in the UNOS/OPTN database (n = 155). Survivals were calculated with the Kaplan–Meier method and compared using the log‐rank test. All statistics were performed in SPSS 15.0. We performed OLT on nine pediatric patients with CFLD, with age ranging from nine to 17 yr at the time of transplant. Mean survival was 69.2 months; patient and allograft survivals at o...
Source: Pediatric Transplantation - March 15, 2013 Category: Transplant Surgery Authors: Theresa R. Harring, N. Thao T. Nguyen, Hao Liu, Saul J. Karpen, John A. Goss, Christine A. O'Mahony Tags: Original Article Source Type: research

Transition from brand to generic tacrolimus is associated with a decrease in trough blood concentration in pediatric heart transplant recipients
Abstract There are limited data available on the bioequivalence of generic and brand‐name tacrolimus in pediatric and heart transplant patients. We characterized changes in 12‐hour trough concentrations and clinical outcomes after transition from brand to generic tacrolimus in pediatric thoracic organ transplant recipients. Patients with a pharmacy‐confirmed date of switch between generic and brand tacrolimus were identified, as well as a matched control group that did not switch for comparison. We identified 18 patients with a confirmed date of switch, and in 12 patients that remained on the same dose, trough concen...
Source: Pediatric Transplantation - October 26, 2015 Category: Transplant Surgery Authors: Son Q. Duong, Ashwin K. Lal, Rujuta Joshi, Brian Feingold, Raman Venkataramanan Tags: Original Article Source Type: research

Not So Wondrous Drugs? - New Warnings about Severe Adverse Effects of New, Heavily Marketed Drugs for Hepatits C,
In conclusion, evidence-based medicine rigorously applied suggests that individual health care and health policy decisions should be driven by the best available evidence, mostly from clinical research, about the benefits and harms of tests, treatments, programs, and so on, in the context of what outcomes matter to patients. The skepticism EBM should engender could lead to health care that is more about patients and their outcomes, and less about ideology, hype, and hucksterism. If only such skepticism were easier to find........APPENDIX - Clinical Research about Hepatitis C TreatmentsStarting in March, 2014, we havep...
Source: Health Care Renewal - October 6, 2016 Category: Health Management Tags: adverse effects clinical trials deception evidence-based medicine Gilead hepatitis C marketing Sovaldi Source Type: blogs

Distance is associated with mortality on the waitlist in pediatric liver transplantation
Abstract The distance to liver transplant centers affects outcomes in adult liver transplantation. Because pediatric patients are particularly vulnerable, we hypothesized that distance adversely affects the time to transplantation and waitlist mortality. The SRTR was queried for isolated pediatric liver transplant registrants (under age 18) with valid ZIP code information from 2003 to 2012. Distance was measured from home ZIP code to listing transplant center. Competing events analysis, adjusted for demographic factors, indication, and PELD, was undertaken for transplantation and death while on the waitlist. The median dis...
Source: Pediatric Transplantation - October 31, 2016 Category: Transplant Surgery Authors: Joel T. Adler, Yanik J. Bababekov, James F. Markmann, David C. Chang, Heidi Yeh Tags: Original Article Source Type: research