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Photodynamic Therapy and Its Synergism with Melittin Against Drug-Resistant Acinetobacter baumannii Isolates with High Biofilm Formation Ability
This study was designed to analyze the effect of photodynamic therapy (PDT) as monotherapy and associated with melittin on multidrug-resistant A. baumannii isolates. Sub-lethal doses of photosensitizer, LED, and PDT were determined. The PDT effect on the biofilm and expression of biofilm-associated genes was evaluated by scanning electron microscopy and quantitative real-time PCR (qRT-PCR) methods, respectively. The synergistic effect of PDT and melittin on the survival of MDR/XDR strong biofilm producer isolates was evaluated by checkerboard assay. Survival rates were significantly decreased at the lowest concentration of...
Source: Current Microbiology - August 18, 2023 Category: Microbiology Authors: Laleh Babaeekhou Maryam Ghane Masoumeh Mohammad Rafiee Source Type: research
The PURPOSe cause of death study in stillbirths and neonatal deaths in India and Pakistan: A review
BJOG. 2023 Aug 17. doi: 10.1111/1471-0528.17635. Online ahead of print.ABSTRACTThe PURPOSe study was a prospective, observational study conducted in India and Pakistan to determine the cause of death for stillbirths and preterm neonatal deaths, using clinical data together with minimally invasive tissue sampling (MITS) and the histologic and polymerase chain reaction (PCR) evaluation of fetal/neonatal tissues and the placenta. After evaluating all available data, an independent panel chose a maternal, a placental and a fetal/neonatal cause of death. Here, we summarise the major results. Among the most important findings we...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - August 18, 2023 Category: OBGYN Authors: Robert L Goldenberg Sarah Saleem Shivaprasad S Goudar Janet Moore Gowdar Guruprasad Vardendra Kulkarni Sangappa M Dhaded Shiyam Sunder Tikmani Sidrah Nausheen Shazia Masheer Mangala G Kallapur Najia K Ghanchi Sheetal U Harakuni Imran Ahmed Kay Hwang S Yog Source Type: research
Photodynamic Therapy and Its Synergism with Melittin Against Drug-Resistant Acinetobacter baumannii Isolates with High Biofilm Formation Ability
This study was designed to analyze the effect of photodynamic therapy (PDT) as monotherapy and associated with melittin on multidrug-resistant A. baumannii isolates. Sub-lethal doses of photosensitizer, LED, and PDT were determined. The PDT effect on the biofilm and expression of biofilm-associated genes was evaluated by scanning electron microscopy and quantitative real-time PCR (qRT-PCR) methods, respectively. The synergistic effect of PDT and melittin on the survival of MDR/XDR strong biofilm producer isolates was evaluated by checkerboard assay. Survival rates were significantly decreased at the lowest concentration of...
Source: Current Microbiology - August 18, 2023 Category: Microbiology Authors: Laleh Babaeekhou Maryam Ghane Masoumeh Mohammad Rafiee Source Type: research
The PURPOSe cause of death study in stillbirths and neonatal deaths in India and Pakistan: A review
BJOG. 2023 Aug 17. doi: 10.1111/1471-0528.17635. Online ahead of print.ABSTRACTThe PURPOSe study was a prospective, observational study conducted in India and Pakistan to determine the cause of death for stillbirths and preterm neonatal deaths, using clinical data together with minimally invasive tissue sampling (MITS) and the histologic and polymerase chain reaction (PCR) evaluation of fetal/neonatal tissues and the placenta. After evaluating all available data, an independent panel chose a maternal, a placental and a fetal/neonatal cause of death. Here, we summarise the major results. Among the most important findings we...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - August 18, 2023 Category: OBGYN Authors: Robert L Goldenberg Sarah Saleem Shivaprasad S Goudar Janet Moore Gowdar Guruprasad Vardendra Kulkarni Sangappa M Dhaded Shiyam Sunder Tikmani Sidrah Nausheen Shazia Masheer Mangala G Kallapur Najia K Ghanchi Sheetal U Harakuni Imran Ahmed Kay Hwang S Yog Source Type: research
Application of CRISPR-Cas system in the diagnosis and therapy of ESKAPE infections
Antimicrobial-resistant ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens represent a global threat to human health. ESKAPE pathogens are the most common opportunistic pathogens in nosocomial infections, and a considerable number of their clinical isolates are not susceptible to conventional antimicrobial therapy. Therefore, innovative therapeutic strategies that can effectively deal with ESKAPE pathogens will bring huge social and economic benefits and ease the suffering of tens of thousands of patients. Among th...
Source: Frontiers in cellular and infection microbiology - August 17, 2023 Category: Microbiology Source Type: research
Isolation and characterization of bacteriophages with activities against multi-drug-resistant Acinetobacter nosocomialis causing bloodstream infection in vivo
J Microbiol Immunol Infect. 2023 Aug 5:S1684-1182(23)00151-2. doi: 10.1016/j.jmii.2023.07.012. Online ahead of print.ABSTRACTBACKGROUND: Acinetobacter nosocomialis (A. nosocomialis) is a glucose non-fermentative, gram-negative bacillus that belongs to the Acinetobacter calcoaceticus-baumannii complex. In recent years, studies have found an increased clinical prevalence of A. nosocomialis. However, given the increasing trend of antibiotic resistance, developing new antibacterial agents is vital. Currently, research regarding bacteriophage therapy against A. nosocomialis is only limited.METHODS: Two A. nosocomialis bacteriop...
Source: Journal of Microbiology, Immunology, and Infection - August 16, 2023 Category: Microbiology Authors: Ho Yin Pekkle Lam Meng-Jiun Lai Wen-Jui Wu Ying-Hao Chin Huei-Jen Chao Li-Kuang Chen Shih-Yi Peng Kai-Chih Chang Source Type: research
Exploring influence mechanism of small-molecule carbon source on heterotrophic nitrification aerobic denitrification process from carbon metabolism, nitrogen metabolism and electron transport process
Bioresour Technol. 2023 Aug 14:129681. doi: 10.1016/j.biortech.2023.129681. Online ahead of print.ABSTRACTThe heterotrophic nitrification-aerobic denitrification (HNAD) process can remove nitrogen and organic carbon under aerobic conditions. To get the in-depth mechanism of the HAND process, a strain named Acinetobacter johnsonii ZHL01 was isolated, and enzyme activity, electron transport, energy production, and gene expression of the strain were studied with small-molecule carbon sources, including sodium citrate, sodium acetate, sodium fumarate, and sodium succinate. The HNAD pathway of ZHL01 was NH4+→NH2OH → NO, and...
Source: Bioresource Technology - August 16, 2023 Category: Biotechnology Authors: Juntong Leng Jiyan Lu Chao Hai Xinyi Liu Pei Wu Yan Sun Chunbo Yuan Jianqiang Zhao Bo Hu Source Type: research
Isolation and characterization of bacteriophages with activities against multi-drug-resistant Acinetobacter nosocomialis causing bloodstream infection in vivo
J Microbiol Immunol Infect. 2023 Aug 5:S1684-1182(23)00151-2. doi: 10.1016/j.jmii.2023.07.012. Online ahead of print.ABSTRACTBACKGROUND: Acinetobacter nosocomialis (A. nosocomialis) is a glucose non-fermentative, gram-negative bacillus that belongs to the Acinetobacter calcoaceticus-baumannii complex. In recent years, studies have found an increased clinical prevalence of A. nosocomialis. However, given the increasing trend of antibiotic resistance, developing new antibacterial agents is vital. Currently, research regarding bacteriophage therapy against A. nosocomialis is only limited.METHODS: Two A. nosocomialis bacteriop...
Source: Journal of Microbiology, Immunology, and Infection - August 16, 2023 Category: Microbiology Authors: Ho Yin Pekkle Lam Meng-Jiun Lai Wen-Jui Wu Ying-Hao Chin Huei-Jen Chao Li-Kuang Chen Shih-Yi Peng Kai-Chih Chang Source Type: research
The utilization of nanopore targeted sequencing proves to be advantageous in the identification of infections present in deceased donors
ConclusionThe pathogen detection technology NTS has a high sensitivity and positive rate. It can more accurately and earlier detect infection in deceased donors, which could be very important for raising the donation conversion rate.
Source: Frontiers in Microbiology - August 16, 2023 Category: Microbiology Source Type: research
Acinetobacter baumannii: A multidrug-resistant pathogen, has emerged in Saudi Arabia
Saudi Med J. 2023 Aug;44(8):732-744. doi: 10.15537/smj.2023.44.8.20230194.ABSTRACTA significant opportunistic pathogen, Acinetobacter baumannii (A. baumannii) has evolved mechanisms of resistance to a wide variety of antimicrobials, including carbapenems. In this article, we assessed the prevalence, risk factors, antimicrobial sensitivity, and resistance mechanisms among A. baumannii in several locations in Saudi Arabia. Hospital-acquired infections caused by A. baumannii were prevalent in the country due to a variety of reasons, such as the high number of critically ill patients, the frequency of gastrointestinal coloniza...
Source: Saudi Medical Journal - August 15, 2023 Category: Middle East Health Authors: Jehad A Aldali Source Type: research
