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Total 427 results found since Jan 2013.

Fight Aging! Newsletter, May 25th 2020
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/ Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitochondri...
Source: Fight Aging! - May 24, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Common cold, flu, or coronavirus?
  In the early days of the outbreak, the novel coronavirus (COVID-19) was repeatedly compared to the flu (influenza) and even to the common cold (rhinoviruses, et al). This was due to an initial impression of shared symptoms. The differences between these conditions are particularly important as we kick off National Influenza Vaccination Week (NIVW) and the ‘flu season’. So, how can we tell which of these diseases we are dealing with in a given patient?     Common cold Let’s start with the common cold, a condition that can be caused by over 200 different strains of viruses.  On average, an adult wil...
Source: GIDEON blog - December 8, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Diagnosis Identify News Source Type: blogs

Fight Aging! Newsletter, January 11th 2021
This study demonstrates the potential of a natural (o-Vanillin) and a synthetic (RG-7112) senolytic compounds to remove senescent IVD cells, decrease SASP factors release, reduce the inflammatory environment and enhance the IVD matrix production. Removal of senescent cells, using senolytics drugs, could lead to improved therapeutic interventions and ultimately decrease pain and a provide a better quality of life of patients living with intervertebral disc degeneration and low back pain. From Ying Ann Chiao of Oklahoma Medical Research Foundation: Mitochondrial dysfunction plays a central role in aging and cardiovasc...
Source: Fight Aging! - January 10, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Positive New Data for Johnson & Johnson Single-Shot COVID-19 Vaccine on Activity Against Delta Variant and Long-lasting Durability of Response
NEW BRUNSWICK, N.J., July 1, 2021 – Johnson & Johnson (NYSE: JNJ) (the Company) today announced data that demonstrated its single-shot COVID-19 vaccine generated strong, persistent activity against the rapidly spreading Delta variant and other highly prevalent SARS-CoV-2 viral variants. In addition, the data showed that the durability of the immune response lasted through at least eight months, the length of time evaluated to date. The two preprint study summaries have been submitted today to bioRxiv. “Today’s newly announced studies reinforce the ability of the Johnson & Johnson COVID-19 vaccine to help prot...
Source: Johnson and Johnson - July 1, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

COVID-19 (Omicron strain) hospital admissions from a virtual ward - who required further care?
CONCLUSIONS: Few patients required admission from the virtual ward in the setting of the Omicron variant (BA.1, BA.2) as a direct result of COVID-19 disease and virtual ward care. Shortness of breath and chest pain were the most common symptoms driving further clinical care.PMID:36991540 | PMC:PMC10040950 | DOI:10.1111/irv.13108
Source: Respiratory Care - March 30, 2023 Category: Respiratory Medicine Authors: Ian Mackay Megan France Duncan McAuley Sean Wing Mary Wheeldon Susan Britton Catherine Todd Alexandra Pitiris Leah Barrett-Beck Elizabeth Rushbrook Cameron Bennett Kate McCarthy Source Type: research

Healthcare Update 01-14-2013
Interesting facts about the human body. Did you know that your stomach acid can melt zinc? Your femur is 4 times stronger than concrete? In your life you make enough saliva to fill two swimming pools? More strange facts at the link. If your stomach acid can’t dissolve it, then try some Coca-Cola. Study shows that Coke is quite effective in dissolving physobezoars (balls of indigestible plant material) in the stomach. Having sex … in a hospital bed … with other people in the room … after just delivering a baby? Look for pictures on the internet – another patient’s family took the pictures and visitors ar...
Source: WhiteCoat's Call Room - January 14, 2013 Category: Emergency Medicine Doctors Authors: WhiteCoat Tags: Healthcare Update Source Type: blogs

Safety and reactogenicity of primary vaccination with the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine in Vietnamese infants: a randomised, controlled trial
Conclusions: PHiD-CV had a clinically acceptable safety profile when co-administered with DTPa-HBV-IPV/Hib in Vietnamese infants. The reactogenicity of PHiD-CV was comparable to that observed in other South-East Asian populations. This study has been registered at www.clinicaltrials.gov NCT01153841.
Source: BMC Infectious Diseases - February 21, 2013 Category: Infectious Diseases Authors: Tran HuuNguyen ToanHa TuanHo VietPham Le Thanh BinhTa-Wen YuFakrudeen ShafiAhsan HabibDorota Borys Source Type: research

Bill Gates Continues ‘God’s Work’, Third World Vaccine Workers Shot Dead
CONCLUSION It appears that Mr. Gates will go to any lengths to vaccinate the world, even if the world makes it very clear that they do not want his vaccines. Rather than vaccinating more children, if he was such a humanitarian, why has he allowed vulnerable, sick children to be dumped in the middle of nowhere to die? Surely the world would applaud him far more loudly if he spent his millions making sure that any vaccine casualties were sufficiently cared for.   References 1. http://www.telegraph.co.uk/technology/bill-gates/9812672/… 2. http://www.guardian.co.uk/world/2012/dec/18/polio… 3. http://www.guardi...
Source: vactruth.com - February 26, 2013 Category: Health Medicine and Bioethics Commentators Authors: Christina England Tags: Christina England Top Stories Adverse Events Bill Gates MenAfriVac population control Source Type: blogs

Ultra-rapid reviews, first test results
In conclusion, this is early days and our first testing steps.  The results have been very encouraging and when our new system is out it'll be even better.  But much more testing is required!Oh yes, the time taken - if you're interested, then scroll down.With the exception of the second to last result they all took around 2-3 minutes.  The second to last one took approximately 5 minutes (as I had to scroll through around 55 results to select the 17 that we used). 
Source: Liberating the literature - August 2, 2013 Category: Technology Consultants Source Type: blogs

Acceptability of immunization in adult contacts of infants: Possibility of expanding platforms to increase adult vaccine uptake.
CONCLUSIONS: Most adults were willing to be vaccinated if offered during hospital visits or clinic appointments for mother or infant. Development and expansion of recommended immunization platforms, such as the cocooning platform, offers the opportunity to increase adult vaccination coverage. PMID: 24681227 [PubMed - as supplied by publisher]
Source: Vaccine - March 26, 2014 Category: Allergy & Immunology Authors: Beel ER, Rench MA, Montesinos DP, Healy CM Tags: Vaccine Source Type: research

Evaluation of safety and immunogenicity of HNVAC, an MDCK-based H1N1 pandemic influenza vaccine, in Phase I single centre and Phase II/III multi-centre, double-blind, randomized, placebo-controlled, parallel assignment studies.
Abstract The clinical evaluation of the MDCK-based H1N1 pandemic influenza vaccine HNVAC in adults aged 18-65 years is reported. In the Phase I randomized, double-blind, placebo-controlled, single-centre study, 160 subjects were parallelly assigned 3:1 to vaccine:placebo groups (n=60:20) with both the aluminium hydroxide adjuvanted and non-adjuvanted vaccine formulations. A single dose of both the formulations containing 15μg of haemagglutinin protein showed minimal adverse reactions, the most common of which were pain at injection site (11.67%) and fever (10.0%). Both formulations produced 74-81% seroprotection ...
Source: Vaccine - May 20, 2014 Category: Allergy & Immunology Authors: Basavaraj VH, Sampath G, Hegde NR, Mohan VK, Ella KM Tags: Vaccine Source Type: research

Can You Avoid Lumbar Puncture in Febrile Neonates?
I don’t have a problem with lumbar punctures in febrile neonates. In fact, my son ended up with three lumbar punctures before aging out of the febrile seizure protocols. I do have a problem, however, with doing unnecessary spinal taps. The emotional stress of a neonatal LP on parents is significant, and the physical stress of the procedure on the infant is also substantial.     The pain of the needle and the unique restraint required for the procedure are also potentially problematic. The pain of the needle can be minimized by EMLA cream (eutectic mixture of local anesthetics [lidocaine and prilocaine]) and local anes...
Source: M2E Too! Mellick's Multimedia EduBlog - May 1, 2014 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs

Healthcare Update Satellite — 12-16-2014
Answering the important questions … why does the flu vaccine suck this year? Keep a lookout for next month’s issue of EP Monthly which will tell you everything you need to know about influenza diagnosis and treatment. Of course, if you had read the backboard article in EP Monthly’s November issue, you’d already be doing this … Florida fire department abandons use of backboards for most trauma patients. 4 year old boy develops carotid artery dissection and left sided hemiparesis after riding a roller coaster. Fortunately, he had made significant recovery by six months. How scary is that, though...
Source: WhiteCoat's Call Room - December 17, 2014 Category: Emergency Medicine Authors: WhiteCoat Tags: Healthcare Update Source Type: blogs

A Year in Review: FDA 2015 New Drug Approvals
The approval of first-of-a-kind drugs rose last year to forty-one, resulting in the highest level of newly approved U.S. drugs in nineteen years. The total number of new drugs approved last year was even higher at sixty-nine. The rising figures reflect an industry-wide desire to research and develop drugs for rare and hard-to-treat diseases. The newly approved drugs serve to advance medical care and the health of patients suffering from many ailments, including various forms of cancer, heart failure, and cystic fibrosis. Additionally, more than 40% of the new therapies were approved for treatment of rare or "orphan" dise...
Source: Policy and Medicine - January 13, 2016 Category: American Health Authors: Thomas Sullivan - Policy & Medicine Writing Staff Source Type: blogs