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Specialty: Allergy & Immunology
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Total 72221 results found since Jan 2013.
LncRNA LINC00184 promotes docetaxel resistance and immune escape via miR-105-5p/PD-L1 axis in prostate cancer
CONCLUSIONS: LINC00184 promoted docetaxel resistance and immune escape in prostate cancer cells by adsorption of miR-105-5p, resulted in upregulation of the expression of PD-L1. LINC00184 could possibly be considered as a potential target for treatment in prostate cancer patients with docetaxel-resistance.PMID:34896914 | DOI:10.1016/j.imbio.2021.152163
Source: Immunobiology - December 13, 2021 Category: Allergy & Immunology Authors: Wei Zhang Jun Xin Jinjin Lai Wenbin Zhang Source Type: research
Identification and validation of Osteopontin and receptor for hyaluronic acid-mediated motility (RHAMM, CD168) for potential immunotherapeutic significance of in lung squamous cell carcinoma
CONCLUSIONS: By using integrated bioinformatics, we have identified CD168 and OPN as DEGs with poor prognosis in LUSC and have validated their interaction in the ECM receptor pathway. These genes could be potential diagnostic and therapeutic targets for LUSC patients undergoing immunotherapy.PMID:35334357 | DOI:10.1016/j.intimp.2022.108715
Source: International Immunopharmacology - March 25, 2022 Category: Allergy & Immunology Authors: Gao Shan Li Meihe Kang Minchao Zhao Rui Wen Xiaopeng Zhang Guangjian Zheng Jin Source Type: research
Utilizing Google trends to monitor coronavirus vaccine interest and hesitancies
CONCLUSION: Misinformation RSVs were highest after FDA authorization and have multiple repeated spikes after subsequent vaccine announcements. General information seeking terms peaked concurrently with increased vaccination uptake in the United States. Search interest has decreased with wider vaccine availability, despite many individuals in the United States remaining unvaccinated. GT can be used to monitor trends in public attitudes and misinformation regarding COVID-19 vaccines and further target education.PMID:35660035 | PMC:PMC9149202 | DOI:10.1016/j.vaccine.2022.05.070
Source: Vaccine - June 6, 2022 Category: Allergy & Immunology Authors: Emily Merrick Joshua P Weissman Sameer J Patel Source Type: research
Acetate, a gut bacterial product, ameliorates ischemia-reperfusion induced acute lung injury in rats
In this study, we examine whether SCFAs have protective effects against IR-induced ALI and explore possible protective mechanisms. IR-induced ALI was established by 40 min ischemia followed by 60 min reperfusion in isolated perfused rat lungs. Rats were randomly assigned to one of six groups: control, control + acetate (400 mg/kg), IR, and IR + acetate at one of three dosages (100, 200, 400 mg/kg). Bronchoalveolar lavage fluids (BALF) and lung tissues were obtained and analyzed at the end of the experiment. In vitro, mouse lung epithelial cells (MLE-12) subjected to hypoxia-reoxygenation (HR) were pretreated with acetate (...
Source: International Immunopharmacology - August 14, 2022 Category: Allergy & Immunology Authors: Kuei-Yi Hung Shu-Yu Wu Hsin-Ping Pao Wen-I Liao Shi-Jye Chu Source Type: research
Inhibition of MyD88 attenuates angiotensin II-induced hypertensive kidney disease via regulating renal inflammation
CONCLUSION: These results demonstrate that Ang II induces inflammation and fibrosis in renal tubular epithelial cells through MyD88 and present MyD88 as a potential point of intervention for hypertension-associated kidney disease.PMID:36116148 | DOI:10.1016/j.intimp.2022.109218
Source: International Immunopharmacology - September 18, 2022 Category: Allergy & Immunology Authors: Ke Lin Wu Luo Na Yang Lan Su Hao Zhou Xiang Hu Yi Wang Zia A Khan Weijian Huang Gaojun Wu Guang Liang Source Type: research
Extracellular vesicles of Clonorchis sinensis promote IL-6 and TNF- α secretion via the Toll-like receptor 9-mediated ERK pathway in biliary epithelial cells
Dev Comp Immunol. 2022 Sep 29:104555. doi: 10.1016/j.dci.2022.104555. Online ahead of print.ABSTRACTClonorchis sinensis is closely associated with cholangitis, cholecystitis, biliary fibrosis and cholangiocarcinoma. The present study elucidated the role of extracellular vesicles of C. sinensis (CsEVs) in activating Toll-like receptor 9 (TLR9) and regulating inflammatory responses. The results showed that TLR9 expression was increased in the livers of C. sinensis-infected mice. CsEVs were cup-shaped or saucer-shaped and 80-120 nm in diameter. CsEVs activated TLR9 and promoted IL-6 and TNF-α expression in mouse biliary epit...
Source: Developmental and Comparative Immunology - October 2, 2022 Category: Allergy & Immunology Authors: Yuru Wang Xiaocen Wang Nan Zhang Yanhui Yu Penglin Bao Yeting Ma Haoyang Zhang Xu Zhang Xichen Zhang Pengtao Gong Xin Li Jianhua Li Source Type: research
HDAC5 RNA interference ameliorates acute renal injury by upregulating KLF2 and inhibiting NALP3 expression in a mouse model of oxalate nephropathy
Int Immunopharmacol. 2022 Sep 29;112:109264. doi: 10.1016/j.intimp.2022.109264. Online ahead of print.ABSTRACTKrüppel-like factor 2 (KLF2) and NLR family pyrin domain containing 3 (NALP3) are important regulators of macrophage activation in the context of various pathological conditions. NALP3 also plays an important role in the maturation of IL-1 β which is central to the pathogenesis of acute oxalate nephropathy. The functional role of KLF2 and regulation of both KLF2 and NALP3 in the pathogenesis of acute oxalate nephropathy is comparably less studied. Here, we explored the regulation of KLF2 and NALP3 by Histone deac...
Source: International Immunopharmacology - October 2, 2022 Category: Allergy & Immunology Authors: Pravesh Sharma Kalyani Karnam Ashutosh Mahale Kavitha Sedmaki Vamsi Krishna Venuganti Onkar Prakash Kulkarni Source Type: research
Nrf2 regulates the expression of NOX1 in TNF- α-induced A549 cells
In this study, we analyzed the potential regulatory role of nuclear factor erythroid-2-related factor 2 (Nrf2) on NADPH oxidase 1 (NOX1) in tumor necrosis factor-α (TNF-α)-induced inflammation and oxidative stress in human type II alveolar epithelial cells. In this study, A549 cells were transfected with Nrf2 siRNA and overexpression vectors for 6 h before being induced by TNF-α for 24 h. TNF-α upregulated the expression of NOX1 and Nrf2 in A549 cells. Furthermore, overexpression of Nrf2 could reduce TNF-α-induced NF-κB mRNA and protein expression after transfection with the Nrf2 siRNA vector, and the levels of IL-6,...
Source: Allergologia et Immunopathologia - January 9, 2023 Category: Allergy & Immunology Authors: Weijing Wu Jiamin Zhang Xiaoshan Su Xiaoping Lin Li Zhu Zesen Zhuang Chennan Liu Zhixing Zhu Yiming Zeng Source Type: research
Regulatory effect of IL-38 on NF- κB pathway in systemic lupus erythematosus
CONCLUSION: IL-38 may be involved in the occurrence and development of SLE by regulating the NF-κB signaling pathway. This study only discussed the relationship between IL-38 and NF-κB, and more biological functions of IL-38 need to be further studied.PMID:36621308 | DOI:10.1016/j.imbio.2022.152322
Source: Immunobiology - January 9, 2023 Category: Allergy & Immunology Authors: Jiyun Zhang Nurshati Tabush Chune Wei Li Luo Source Type: research
Nrf2 regulates the expression of NOX1 in TNF- α-induced A549 cells
In this study, we analyzed the potential regulatory role of nuclear factor erythroid-2-related factor 2 (Nrf2) on NADPH oxidase 1 (NOX1) in tumor necrosis factor-α (TNF-α)-induced inflammation and oxidative stress in human type II alveolar epithelial cells. In this study, A549 cells were transfected with Nrf2 siRNA and overexpression vectors for 6 h before being induced by TNF-α for 24 h. TNF-α upregulated the expression of NOX1 and Nrf2 in A549 cells. Furthermore, overexpression of Nrf2 could reduce TNF-α-induced NF-κB mRNA and protein expression after transfection with the Nrf2 siRNA vector, and the levels of IL-6,...
Source: Allergologia et Immunopathologia - January 9, 2023 Category: Allergy & Immunology Authors: Weijing Wu Jiamin Zhang Xiaoshan Su Xiaoping Lin Li Zhu Zesen Zhuang Chennan Liu Zhixing Zhu Yiming Zeng Source Type: research
