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Vaccination: Influenza Vaccine
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Total 427 results found since Jan 2013.
Immunogenicity and safety of an AS03-adjuvanted H7N1 vaccine in adults 65years of age and older: A phase II, observer-blind, randomized, controlled trial.
CONCLUSIONS: In adults aged ≥65years, the adjuvanted H7N1 vaccine was immunogenic after 2 doses, and had an acceptable safety profile. www.ClinicalTrials.gov: NCT01949090.
PMID: 28302407 [PubMed - as supplied by publisher]
Source: Vaccine - March 12, 2017 Category: Allergy & Immunology Authors: Madan A, Ferguson M, Rheault P, Seiden D, Toma A, Friel D, Soni J, Li P, Innis BL, Schuind A Tags: Vaccine Source Type: research
Emergency Department Intervention May Reduce Suicide Attempts in At-Risk Patients
Astudy published April 29 inJAMA Psychiatry reports that a multifaceted intervention incorporating screening, safety planning guidance, and periodic telephone follow-up can reduce the risk of suicidal behavior in at-risk individuals who present in the emergency department (ED).The reductions were modest but clinically significant; compared with usual ED treatment, the number of patients who attempted suicide dropped by about 20% and the total number of suicide attempts dropped by about 30%.“We would like to have had an even stronger effect, but the fact that we were able to impact attempts with this population and w...
Source: Psychiatr News - May 2, 2017 Category: Psychiatry Tags: emergency department suicidal risk suicide prevention suicide screening Source Type: research
Advances Towards Painless Vaccination and Newer Modes of Vaccine Delivery
AbstractVaccines have been successful in reducing the mortality and morbidity, but most of them are delivered by intramuscular or intravenous route. They are associated with pain to the baby and bring lot of anxiety for the parents. There has been a marked increase in the number of injections required in first two years of life for completing the vaccination schedule. Hence, there is a need to have a painless vaccine delivery system. Numerous new routes of vaccination like, oral, nasal and transdermal routes are being tried. Oral polio and intranasal influenza have already been a success. Other newer approaches like edible...
Source: Indian Journal of Pediatrics - June 16, 2017 Category: Pediatrics Source Type: research
The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo-controlled, phase 1 trial
We describe safety, immunogenicity, and acceptability of the first-in-man study on single, dissolvable microneedle patch vaccination against influenza. Methods The TIV-MNP 2015 study was a randomised, partly blinded, placebo-controlled, phase 1, clinical trial at Emory University that enrolled non-pregnant, immunocompetent adults from Atlanta, GA, USA, who were aged 18–49 years, naive to the 2014–15 influenza vaccine, and did not have any significant dermatological disorders. Participants were randomly assigned (1:1:1:1) to four groups and received a single dose of inactivated influenza vaccine (fluvirin: 18 μg of hae...
Source: The Lancet - June 28, 2017 Category: General Medicine Source Type: research
Vaccine Adverse Events: Separating Myth from Reality.
Abstract
Vaccines are one of the most successful medical advances in modern times. Most vaccine-preventable illnesses are unfamiliar to modern parents. Because of this, parents are increasingly questioning the necessity of immunizing their children, especially because no vaccine is completely free of adverse effects or the risk of complications. Family physicians should be aware of the risks and benefits of recommended immunizations. Thimerosal is currently used only in multidose vials of influenza vaccine, and exposure through vaccines is not associated with adverse neurologic outcomes. The measles, mumps, and ru...
Source: American Family Physician - June 15, 2017 Category: Primary Care Authors: Spencer JP, Trondsen Pawlowski RH, Thomas S Tags: Am Fam Physician Source Type: research
Evaluation of a primary course of H9N2 vaccine with or without AS03 adjuvant in adults: A phase I/II randomized trial.
CONCLUSIONS: All H9N2 vaccine formulations were immunogenic with a clinically acceptable safety profile; adjuvanted formulations were 4-8 times dose-sparing (3.75-1.9vs 15µgHA).
TRIAL REGISTRATION: Registered on ClinicalTrials.gov: NCT01659086.
PMID: 28720281 [PubMed - as supplied by publisher]
Source: Vaccine - July 15, 2017 Category: Allergy & Immunology Authors: Madan A, Collins H, Sheldon E, Frenette L, Chu L, Friel D, Drame M, Vaughn DW, Innis BL, Schuind A Tags: Vaccine Source Type: research
Development of quality metrics for ambulatory pediatric cardiology: Infection prevention
ConclusionsThe lack of convincing data to guide quality improvement initiatives in pediatric cardiology is widespread, particularly in infection prevention. Despite this, three metrics were able to be developed for use in the ACC's quality efforts for ambulatory practice.
Source: Congenital Heart Disease - May 1, 2017 Category: Cardiology Authors: Jonathan N. Johnson, Cindy S. Barrett, Wayne H. Franklin, Eric M. Graham, Nancy J. Halnon, Brandy A. Hattendorf, Catherine D. Krawczeski, James J. McGovern, Matthew J. O'Connor, Amy H. Schultz, Jeffrey M. Vinocur, Devyani Chowdhury, Jeffrey B. Anderson Tags: ORIGINAL ARTICLE Source Type: research
Risk of bursitis and other injuries and dysfunctions of the shoulder following vaccinations.
Abstract
While vaccination injection site adverse reactions are usually mild and transient in nature, several cases of bursitis and other shoulder injuries have been reported in the medical literature. However, these lesions are not included in vaccine label inserts. To identify the characteristics of post-vaccination shoulder injuries and those of patients and involved vaccines, as well as their potential causes, a systematic review of the cases of vaccination-related bursitis and other shoulder injuries reported in the literature and notified to the Spanish Pharmacovigilance System database (FEDRA) have been con...
Source: Vaccine - July 31, 2017 Category: Allergy & Immunology Authors: Martín Arias LH, Sanz Fadrique R, Sáinz Gil M, Salgueiro-Vazquez ME Tags: Vaccine Source Type: research
No drop in flu vaccinations since nasal spray withdrawn, CDC says
Discontinuation of the pain-free nasal spray flu vaccine hasn't led to a drop in childhood influenza vaccination -- at least not in Oregon.
Source: Health News - UPI.com - October 6, 2017 Category: Consumer Health News Source Type: news
No Drop in Flu Vaccinations Since Nasal Spray Withdrawn
FRIDAY, Oct. 6, 2017 -- Discontinuation of the pain-free nasal spray flu vaccine hasn ' t led to a drop in childhood influenza vaccination -- at least not in Oregon.
In 2016, the U.S. Centers for Disease Control and Prevention ' s advisory committee on...
Source: Drugs.com - Daily MedNews - October 6, 2017 Category: General Medicine Source Type: news
Rapid changes in serum cytokines and chemokines in response to inactivated influenza vaccination
ConclusionsSerum cytokines changed rapidly following TIV and generally peaked at 24 hours. TIV‐induced reductions in IL‐8 occurred later (44h) and were sustained for 2 weeks. An outlier response coincided with the only moderate side effects to the vaccine. These data suggest that early cytokine/chemokine responses may provide additional insight into the pathogenesis of adverse events and immune reactivity to vaccination.This article is protected by copyright. All rights reserved.
Source: Influenza and Other Respiratory Viruses - September 1, 2017 Category: Virology Authors: Kawsar R. Talaat, Neal A. Halsey, Amber B. Cox, Christian L. Coles, Anna P. Durbin, Amritha Ramakrishnan, Jay H. Bream Tags: Original Article Source Type: research
Immunogenicity and safety of an inactivated quadrivalent influenza vaccine co-administered with a 23-valent pneumococcal polysaccharide vaccine versus separate administration, in adults ≥50years of age: Results from a phase III, randomized, non-inferiority trial.
CONCLUSION: The IIV4 and PPV23 can be co-administered without reducing antibody responses reflecting protection against influenza or pneumococcal disease. Co-administration of PPV23 at the annual influenza vaccination visit may improve uptake. Comorbidities had no impact on IIV4 immunogenicity, supporting its value in older adults with chronic medical conditions. Clinical Trial Registry Number: NCT02218697.
PMID: 28987445 [PubMed - as supplied by publisher]
Source: Vaccine - October 5, 2017 Category: Allergy & Immunology Authors: Ofori-Anyinam O, Leroux-Roels G, Drame M, Aerssens A, Maes C, Amanullah A, Schuind A, Li P, Jain VK, Innis BL Tags: Vaccine Source Type: research
Digital Maps Help Fight Epidemics
Have you ever thought that it would be possible to monitor drug overdoses, Zika cases or the spread of the flu in real time? Have you ever imagined that satellites wouldbe able to tell how and where a malaria epidemic will happen months before the actual outbreak? It is mind-blowing how, in the last years, digital maps developed to a level where they serve as effective tools for evaluating, monitoring and even predicting health events. That’s why I decided to give a comprehensive overview of digital maps in healthcare.
John Snow, cholera and the revolution of maps in healthcare
Before Game of Thrones monopolized John Sn...
Source: The Medical Futurist - October 12, 2017 Category: Information Technology Authors: nora Tags: Future of Medicine Healthcare Design Mobile Health digital health digital technology epidemics epidemiology gc4 Innovation interactive maps Source Type: blogs
What ’s new with the flu shot?
Should you get the influenza (flu) vaccine this year? The short, quick answer (barring any medical reasons you shouldn’t, such as severe allergies), is yes! But recent research raises another important question: When should you get the shot?
Why a flu shot every year in the first place?
Getting infected with the flu can be dangerous — we’ve seen patients in the ICU who were previously healthy but had a horrible response to a strain of the virus and became very sick.
Every year the Centers for Disease Control and Prevention (CDC) and other agencies release flu vaccination guidelines in late summer to early fall. The f...
Source: Harvard Health Blog - November 13, 2017 Category: Consumer Health News Authors: Dominic Wu, MD Tags: Cold and Flu Health Infectious diseases Prevention Vaccines Source Type: blogs
HealthWatch: Can The Flu Cause A Heart Attack?
BOSTON (CBS) — It’s bad enough to get the flu but could you also be at risk of suffering a heart attack while you’re sick?
Well, a new study published in the New England Journal of Medicine finds a significant association between respiratory infections, especially the flu, and suffering a heart attack.
Researchers looked at hospitalizations for heart attack one year before and one year after a positive test for influenza.
They found that the risk of admission for acute heart attack was six times higher in the seven days after testing positive for the flu.
The risks were highest for older adults, those who...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 24, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health Healthwatch Local News Seen On WBZ-TV Syndicated Local Dr. Mallika Marshall Flu Flu Vaccine Source Type: news
