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Specialty: Allergy & Immunology

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Total 72221 results found since Jan 2013.

TonEBP Suppresses the HO-1 Gene by Blocking Recruitment of Nrf2 to Its Promoter
Discussion Dynamic changes in the functional phenotype of macrophages are associated with pathogenesis of inflammatory diseases (5–7). TonEBP primes macrophages toward an M1 phenotype, which has pro-inflammatory properties. TonEBP does this by promoting expression of pro-inflammatory genes via interaction with NF-κB (36) and by binding directly to the promoter (37, 64). In addition, TonEBP suppresses expression of the anti-inflammatory cytokine IL-10 by limiting chromatin access to the promoter (37). The pro-inflammatory function of TonEBP suggests that inhibiting its expression or activation could suppres...
Source: Frontiers in Immunology - April 17, 2019 Category: Allergy & Immunology Source Type: research

GRK2 participation in cardiac hypertrophy induced by isoproterenol through the regulation of Nrf2 signaling and the promotion of NLRP3 inflammasome and oxidative stress
CONCLUSION: According to the results of this study, GRK2 participated in cardiac hypertrophy induced by ISO by mitigating NLRP3 inflammasome and oxidative stress through the signaling of Nrf2 in H9c2 cells.PMID:37012864 | DOI:10.1016/j.intimp.2023.109957
Source: International Immunopharmacology - April 4, 2023 Category: Allergy & Immunology Authors: Jing Liu Xiaoli Li Lu Ding Wei Li Xiaolin Niu Dengfeng Gao Source Type: research

Therapeutic Small Interfering RNA Targeting Complement C3 in a Mouse Model of C3 Glomerulopathy
In this study, we investigated the effects of N-acetylgalactosamine (GalNAc)-conjugated small interfering RNA (siRNA) targeting the C3 component of complement that inhibits liver C3 expression in the C3G model of mice with heterozygous deficiency of factor H (Cfh+/- mice). We showed a duration of action for GalNAc-conjugated C3 siRNA in reducing the liver C3 gene expression in Cfh+/- mice that were dosed s.c. once a month for up to 7 mo. C3 siRNA limited fluid-phase alternative pathway activation, reducing circulating C3 fragmentation and activation of factor B. Treatment with GalNAc-conjugated C3 siRNA reduced glomerular ...
Source: Journal of Immunology - March 12, 2022 Category: Allergy & Immunology Authors: Cristina Zanchi Monica Locatelli Domenico Cerullo Verena Aumiller Daniela Corna Daniela Rottoli Mona Eisermann Roberta Donadelli Mansoureh Mousavi Marina Noris Giuseppe Remuzzi Ariela Benigni Carlamaria Zoja Source Type: research

Galectin-3 plays an important pro-inflammatory role in A. fumigatus keratitis by recruiting neutrophils and activating p38 in neutrophils
CONCLUSION: These data proved that A. fumigatus increased Gal-3 expression and elevated disease clinical scores, PMNs infiltration and cytokines expression through Gal-3. In PMNs, A. fumigatus upregulated IL-1β and IL-6 secretion through the Gal-3 / p38 pathway.PMID:33933850 | DOI:10.1016/j.intimp.2021.107706
Source: International Immunopharmacology - May 2, 2021 Category: Allergy & Immunology Authors: Yawen Niu Jing Lin Cui Li Xudong Peng Nan Jiang Qiang Xu Min Yin Hao Lin Lingwen Gu Guiqiu Zhao Source Type: research

Tissue inhibitor of metalloproteinases 1 is involved in ROS-mediated inflammation via regulating matrix metalloproteinase 1 expression in the sea cucumber Apostichopus japonicus
Dev Comp Immunol. 2021 Oct 15:104298. doi: 10.1016/j.dci.2021.104298. Online ahead of print.ABSTRACTTissue inhibitors of metalloproteinases (TIMPs) serve as matrix metalloproteinase (MMP) inhibitors in the pathogenesis of inflammatory diseases in vertebrates. We cloned and characterised the TIMP1 gene from Apostichopus japonicus using RACE approaches (designated as AjTIMP1). For Vibrio splendidus-challenged sea cucumbers, the peak expression of AjTIMP1 mRNAs in coelomocytes was detected at 24 h (23.44-fold) and remained at high levels (4.01-fold) until 72 h. Similarly, AjTIMP1 expression was upregulated in primary coelomoc...
Source: Developmental and Comparative Immunology - October 18, 2021 Category: Allergy & Immunology Authors: Zhimeng Lv Guanghui Han Chenghua Li Source Type: research

Tumor-Stroma-Inflammation Networks Promote Pro-metastatic Chemokines and Aggressiveness Characteristics in Triple-Negative Breast Cancer
In this study, MSCs of four different healthy donors were used. Patient-derived CAFs from a primary breast tumor (used in ELISA and their accompanying signaling experiments) and from a lung metastasis (used in tumor cell invasion assays) were kindly provided by Dr. Bar, Sheba Medical Center, Ramat Gan, Israel). The cells were grown, identified and immortalized as described in Katanov et al. (67). TNFα and IL-1β Concentrations Used in Different Analyses Titration studies were initiated by determining the ability of rhTNFα (#300-01A, PeproTech, Rocky Hill, NJ), and rhIL-1β (#...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

A new nucleic acid–based agent inhibits cytotoxic T lymphocyte–mediated immune disorders
Conclusions: Our results identified a new nucleic acid–based agent (CD8 aptamer–GNLY siRNA chimera) that can significantly inhibit CTL-mediated drug hypersensitivity, such as that seen in patients with SJS/TEN, as well as the alloreactivity seen in patients with GVHD. This study provides a novel therapeutic strategy for CTL-mediated immune disorders.
Source: Journal of Allergy and Clinical Immunology - June 21, 2013 Category: Allergy & Immunology Authors: Chuang-Wei Wang, Wen-Hung Chung, Yi-Fang Cheng, Nien-Wen Ying, Konan Peck, Yuan-Tsong Chen, Shuen-Iu Hung Tags: Mechanisms of allergy and clinical immunology Source Type: research