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Total 141452 results found since Jan 2013.

Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma
CONCLUSIONS: Two doses of DC:Ad-S, one given immediately before and another after ASCT, were feasible and safe. A high frequency of vaccine-specific immune responses was seen in combination with durable clinical outcomes, supporting ongoing investigation into the potential of this approach.PMID:37735756 | DOI:10.1158/1078-0432.CCR-22-3987
Source: Clinical Cancer Research - September 22, 2023 Category: Cancer & Oncology Authors: Ciara L Freeman Reginald Atkins Indumathy Varadarajan Meghan Menges Jeffrey Edelman Rachid Baz Jason Brayer Omar Castaneda Puglianini Jose Leonel Ochoa-Bayona Taiga Nishihori Kenneth H Shain Bijal Shah Dung Tsa Chen Linda Kelley Domenico Coppola Melissa A Source Type: research

Correction: Liver Transplantation After Hepatic Artery Infusion Pump Therapy: Single-Center Experience and Technical Considerations
Ann Surg Oncol. 2023 Sep 22. doi: 10.1245/s10434-023-14351-0. Online ahead of print.NO ABSTRACTPMID:37737969 | DOI:10.1245/s10434-023-14351-0
Source: Ann Oncol - September 22, 2023 Category: Cancer & Oncology Authors: Angela L Hill Darren R Cullinan Ola Ahmed Neeta Vachharajani Meranda D Scherer Franklin Olumba Adeel S Khan William C Chapman Majella B Doyle Source Type: research

EGR1 Promotes Ovarian Hyperstimulation Syndrome Through Upregulation of SOX9 Expression
This study aimed to investigate the function and mechanism of EGR1 involved in OHSS progression. RNA-sequencing was used to identify differentially expressed genes. In vitro OHSS cell model was induced by treating KGN cells with human chorionic gonadotropin (hCG). In vivo OHSS model was established in mice. The expression levels of EGR1, SOX1, and VEGF were determined by Quantitative Real-Time polymerase chain reaction (qRT-PCR), Western blot, immunofluorescence staining, and immunochemistry assay. The content of VEGF in the culture medium of human granulosa-like tumor cell line (KGN) cells was accessed by the ELISA assay....
Source: Cell Transplantation - September 22, 2023 Category: Cytology Authors: Huihui Wang Weijia Chen Yinan Huang Yuan Sun Yuanhua Liu Yuanchao Zhu Zongxuan Lu Source Type: research

Oncolytic virus oHSV2 combined with PD-1/PD-L1 inhibitors exert antitumor activity by mediating CD4  + T and CD8 + T cell infiltration in the lymphoma tumor microenvironment
Autoimmunity. 2023 Dec;56(1):2259126. doi: 10.1080/08916934.2023.2259126. Epub 2023 Sep 22.ABSTRACTA novel therapeutic regimen showed that the oncolytic type II herpes simplex virus (oHSV2) was able to prevent colorectal cancer growth, recurrence, and metastasis. However, no study has yet explored whether oHSV2 has an impact on the development of diffuse large B-cell lymphoma (DLBCL). We chose the clinical chemotherapeutic drug doxorubicin (DOX) as a positive control to evaluate the effect of oHSV2 infection on the apoptotic, invasive, and proliferative capacity of DLBCL cells. We next further explored the therapeutic effi...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Jingbo Zhang Yiwei Guo Huiying Fang Xiuchen Guo Lina Zhao Source Type: research

Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma
CONCLUSIONS: Two doses of DC:Ad-S, one given immediately before and another after ASCT, were feasible and safe. A high frequency of vaccine-specific immune responses was seen in combination with durable clinical outcomes, supporting ongoing investigation into the potential of this approach.PMID:37735756 | DOI:10.1158/1078-0432.CCR-22-3987
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ciara L Freeman Reginald Atkins Indumathy Varadarajan Meghan Menges Jeffrey Edelman Rachid Baz Jason Brayer Omar Castaneda Puglianini Jose Leonel Ochoa-Bayona Taiga Nishihori Kenneth H Shain Bijal Shah Dung Tsa Chen Linda Kelley Domenico Coppola Melissa A Source Type: research

Building the Evidence for Exercise in Solid Organ Transplant: How Far Have We Moved the Needle?
Physiother Can. 2023 Sep 19;75(3):209-211. doi: 10.3138/ptc-2022-0111. eCollection 2023 Sep.NO ABSTRACTPMID:37736416 | PMC:PMC10510535 | DOI:10.3138/ptc-2022-0111
Source: Physiotherapy Canada - September 22, 2023 Category: Physiotherapy Authors: Sunita Mathur Tania Janaudis-Ferreira Manoela de Paula Ferreira Nicholas Bourgeois Tom Blydt-Hansen Tracy Fuller Robin Deliva Lorraine Hamiwka Source Type: research

La collecte de donn ées probantes sur l’exercice en cas de transplantation d’organe plein : à quel point avons-nous progressé?
Physiother Can. 2023 Sep 19;75(3):212-214. doi: 10.3138/ptc-2022-0111-fr. eCollection 2023 Sep.NO ABSTRACTPMID:37736412 | PMC:PMC10510543 | DOI:10.3138/ptc-2022-0111-fr
Source: Physiotherapy Canada - September 22, 2023 Category: Physiotherapy Authors: Sunita Mathur Tania Janaudis-Ferreira Manoela de Paula Ferreira Nicholas Bourgeois Tom Blydt-Hansen Tracy Fuller Robin Deliva Lorraine Hamiwka Source Type: research

What is circulating factor disease and how is it currently explained?
AbstractNephrotic syndrome (NS) consists of the clinical triad of hypoalbuminaemia, high levels of proteinuria and oedema, and describes a heterogeneous group of disease processes with different underlying drivers. The existence of circulating factor disease (CFD) as a driver of NS has been epitomised by a subset of patients who exhibit disease recurrence after transplantation, alongside laboratory work. Several circulating factors have been proposed and studied, broadly grouped into protease components such as soluble urokinase-type plasminogen activator (suPAR), hemopexin (Hx) and calcium/calmodulin-serine protease kinas...
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

Prevalence and risk factors of disordered eating behavior in youth with hypertension disorders
ConclusionsDEB prevalence is higher in youth with HTN disorders and comparable to other conditions requiring lifestyle counseling. Youth with HTN disorders may benefit from DEB screening.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

Increasing SARS-CoV-2 seroprevalence among UK pediatric patients on dialysis and kidney transplantation between January 2020 and August 2021
ConclusionsAnti-SARS-CoV-2 seroprevalence was low in 2020 and increased in early 2021. Serological surveillance complements nucleic acid detection and antigen testing to build a greater picture of the epidemiology of COVID-19 and is therefore important to guide public health responses.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

Lessons Learned During the War in Ukraine Lessons Learned During the War in Ukraine
A new report from the Renal Disaster Relief Task Force sheds light on the consequences of war and disasters on the care and support of people with kidney disease.Nephrology Dialysis Transplantation
Source: Medscape Today Headlines - September 22, 2023 Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news

Mesenchymal Stem Cells as an Adjuvant Tool to Induce Regeneration and Repair in Marginal Renal Allografts
AbstractPurpose of ReviewMesenchymal stem cells (MSC) have been largely studied for more than three decades and have been proposed to treat a myriad of clinical conditions in dozens of clinical trials.Recent FindingsThey have become popular in transplant medicine due to their immunomodulatory properties with promising results. In the past decade, however, they have also been tested in the setting of organ preservation in reason of their ability to induce regeneration and repair in damaged tissues.SummaryThis manuscript reviews the worldwide experience relative to the use of MSC and their by-products, as therapeutic tool to...
Source: Current Transplantation Reports - September 22, 2023 Category: Transplant Surgery Source Type: research

Regenerative Surgery: Is This an Independent Field of Health Sciences or Only a Semantic Exercise?
AbstractPurpose of ReviewThis manuscript aims at contextualizing the termregenerative surgery, whose recent introduction in the medical jargon has generated some confusion on both its significance and interplay with its synonymousregenerative medicine.Recent FindingsThe manuscript will illustrate the worldwide experience relative to the development ofregenerative surgery–related technologies, as they may be applied and be of interest to transplant medicine. Only few centers have invested in these technologies, the most relevant of which is cell on scaffold seeding technologies whereby cells, ideally isolated from the pat...
Source: Current Transplantation Reports - September 22, 2023 Category: Transplant Surgery Source Type: research

Genes, Vol. 14, Pages 1838: Whole-Exome Sequencing of 24 Spanish Families: Candidate Genes for Non-Syndromic Pediatric Keratoconus
Irene Rosa-Pérez Juan Carlos Acal Joana Blasco Marta Naranjo-Castresana Beatriz Ruz-Caracuel Victoria E. F. Montaño Cristina Ortega Patrón M. Esther Rubio-Martín Laura García-Fernández Emi Rikeros-Orozco María de Los Ángeles Gómez-Cano Luna Delgado-Mora Susana Noval Elena Vallespín Keratoconus is a corneal dystrophy that is one of the main causes of corneal transplantation and for which there is currently no effective treatment for all patients. The presentation of this disease in pediatric age is associated with rapid progression, a worse prognosis and, in 15–20% of ...
Source: Genes - September 22, 2023 Category: Genetics & Stem Cells Authors: Carmen Gonz ález-Atienza Elo ísa Sánchez-Cazorla Natalia Villoldo-Fern ández Almudena del Hierro Ana Boto Marta Guerrero-Carretero Mar ía Nieves-Moreno Natalia Arruti Patricia Rodr íguez-Solana Roc ío Mena Carmen Rodr íguez-Jiménez Irene Rosa-P Tags: Article Source Type: research