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A Novel Paradigm Defines Functional Molecule Clusters for an Anti-Alzheimer's Disease Recipe from Traditional Chinese Medicine
In this study, a similarity analysis based on molecular fingerprints was adopted to explore the representative molecules of the Tiaoxin recipe, a Chinese patent formula approved by the National Medical Products Administration (NMPA) for the treatment of mild-to-moderate Alzheimer's disease (AD), and 38 out of 1047 chemicals were finally screened out. Next, we tried to define a new concept of a "functional molecule cluster" for chemicals with similar pharmacological effects to elucidate how the chemical mixture from TCMs produce their therapeutic effects. Four anti-AD functional molecule clusters from the Tiaoxin recipe wer...
Source: The American Journal of Chinese Medicine - August 31, 2023 Category: Complementary Medicine Authors: Peiyi Ji Jianrong Xu Miaomiao Li Chenghuan Song Yongfang Zhang Rui Zhang Hongzhuan Chen Hao Wang Lanxue Zhao Source Type: research
Prevalence, knowledge, and attitudes toward herbal medicines among pregnant women attending antenatal clinic in Prince Mansour Military Hospital in Taif
CONCLUSION: Herbal medicines use during pregnancy is a common practice among women in Taif city, Saudi Arabia. Less frequent ANC visits was associated with high probability of herbal medicine use during pregnancy. Majority of pregnant women agreed that herbals are beneficial if recommended by doctor.PMID:37649749 | PMC:PMC10465024 | DOI:10.4103/jfmpc.jfmpc_295_23
Source: Primary Care - August 31, 2023 Category: Primary Care Authors: Dhelal M Alkhaldi Sawsan S Alkhammash Source Type: research
A Novel Paradigm Defines Functional Molecule Clusters for an Anti-Alzheimer's Disease Recipe from Traditional Chinese Medicine
In this study, a similarity analysis based on molecular fingerprints was adopted to explore the representative molecules of the Tiaoxin recipe, a Chinese patent formula approved by the National Medical Products Administration (NMPA) for the treatment of mild-to-moderate Alzheimer's disease (AD), and 38 out of 1047 chemicals were finally screened out. Next, we tried to define a new concept of a "functional molecule cluster" for chemicals with similar pharmacological effects to elucidate how the chemical mixture from TCMs produce their therapeutic effects. Four anti-AD functional molecule clusters from the Tiaoxin recipe wer...
Source: The American Journal of Chinese Medicine - August 31, 2023 Category: Complementary Medicine Authors: Peiyi Ji Jianrong Xu Miaomiao Li Chenghuan Song Yongfang Zhang Rui Zhang Hongzhuan Chen Hao Wang Lanxue Zhao Source Type: research
Conservation genetics of endangered Trillium govanianum Wall. ex D. Don - a pharmaceutically prized medicinal plant from the Himalaya and implications for species recovery
Gene. 2023 Aug 29:147748. doi: 10.1016/j.gene.2023.147748. Online ahead of print.ABSTRACTUnderstanding the genetic diversity and population structure of pharmaceutically important endangered plant species is crucial for their conservation and sustainable use. Despite the continuous population decline in Trillium govanianum Wall. ex D. Don, a highly prized medicinal plant endemic to the Himalaya, information regarding its conservation genetics has been lacking. Here, we employed a conservation genetics approach to investigate how drastically declining populations in natural habitats impact population genetic diversity and s...
Source: Gene - August 31, 2023 Category: Genetics & Stem Cells Authors: Shahid Ul Islam Zahid Ahmed Mangral Lubna Tariq Basharat Ahmad Bhat Wajahat Waseem Tantray Rameez Ahmad Anzar Ahmad Khuroo Tanvir Ul Hassan Dar Source Type: research
A Novel Paradigm Defines Functional Molecule Clusters for an Anti-Alzheimer's Disease Recipe from Traditional Chinese Medicine
In this study, a similarity analysis based on molecular fingerprints was adopted to explore the representative molecules of the Tiaoxin recipe, a Chinese patent formula approved by the National Medical Products Administration (NMPA) for the treatment of mild-to-moderate Alzheimer's disease (AD), and 38 out of 1047 chemicals were finally screened out. Next, we tried to define a new concept of a "functional molecule cluster" for chemicals with similar pharmacological effects to elucidate how the chemical mixture from TCMs produce their therapeutic effects. Four anti-AD functional molecule clusters from the Tiaoxin recipe wer...
Source: The American Journal of Chinese Medicine - August 31, 2023 Category: Complementary Medicine Authors: Peiyi Ji Jianrong Xu Miaomiao Li Chenghuan Song Yongfang Zhang Rui Zhang Hongzhuan Chen Hao Wang Lanxue Zhao Source Type: research
Pharmacological Benefits and Underlying Mechanisms of < em > Salvia miltiorrhiza < /em > against Molecular Pathology of Various Liver Diseases: A Review
Am J Chin Med. 2023 Aug 30:1-35. doi: 10.1142/S0192415X23500763. Online ahead of print.ABSTRACTSalvia miltiorrhiza Bunge, called Danshen in Chinese, is the dried root and rhizome of S. miltiorrhiza, which is part of the mint family, Lamiaceae; it has chiefly been used to treat blood stasis and improve blood flow in cerebrovascular and cardiovascular diseases for over 2000 years. Recent preclinical studies have indicated that S. miltiorrhiza has a wide range of pharmacological properties making it useful for the treatment of diverse liver diseases. S. miltiorrhiza protects the liver from harmful hepatotoxins, reduces hepati...
Source: The American Journal of Chinese Medicine - August 30, 2023 Category: Complementary Medicine Authors: Cho Hyun Hwang Eungyeong Jang Jang-Hoon Lee Source Type: research
Inter- and intraspecific diversity of Salix bark phenolic profiles - A resource for the pharmaceutical industry
Fitoterapia. 2023 Aug 28:105660. doi: 10.1016/j.fitote.2023.105660. Online ahead of print.ABSTRACTDue to their content of phenolic compounds, willow bark preparations are used as an herbal remedy. The large diversity of phenolic secondary metabolites in Salix still provides a resource for the identification of bioactive compounds in particular species, including species not yet in focus from a phytopharmaceutical perspective. The present study describes the bark phenolic profile of 13 Salix species analyzed by HPLC-MS: Salix alba, Salix babylonica, Salix daphnoides, Salix fragilis, Salix hastata, Salix myrsinifolia, Salix ...
Source: Fitoterapia - August 30, 2023 Category: Biochemistry Authors: Angela K öhler Nadja F örster Matthias Zander Christian Ulrichs Source Type: research
Hosimosines A-E, structurally diverse cytisine derivatives from the seeds of Ormosia hosiei Hemsl. et Wils
Fitoterapia. 2023 Aug 28:105661. doi: 10.1016/j.fitote.2023.105661. Online ahead of print.ABSTRACTOrmosia hosiei Hemsl. et Wils (Fabaceae family) is an arbor species endemic to China. The seeds of O. hosiei have been used as traditional Chinese medicine to treat hernia, abdominal pain, blood stasis and amenorrhea. Cytisine-like and angustifoline type alkaloids were main components identified from this plant. In our research on the bioactive alkaloids from the promising Chinese medicinal plants, four new angustifoline type alkaloids (1-4) and a new cytisine-like alkaloid (5), named hosimosine A-E, together with 13 known ana...
Source: Fitoterapia - August 30, 2023 Category: Biochemistry Authors: Qing-Qing Zhou Xiao-Yan Xie Jia-Wen Zhu Wei-Wei Pan Bao-Gang Xie Wu Zhou Jin-Biao Xu Source Type: research
Secondary metabolites from Aspergillus terreus F6-3, a marine fungus associated with Johnius belengerii
Fitoterapia. 2023 Aug 28:105662. doi: 10.1016/j.fitote.2023.105662. Online ahead of print.ABSTRACTTwo new terrein derivatives asperterreinones A-B (1-2), one new octahydrocoumarin derivative (±)-asperterreinin A (6), along with seventeen known compounds, were isolated from Aspergillus terreus F6-3, a marine fungus associated with Johnius belengerii. The structures of 1, 2, and 6 were established on the basis of 1D and 2D NMR, mass spectroscopy, comparative electronic circular dichroism (ECD) spectra analysis, density functional theory calculation of 13C NMR, and DP4+ probability analysis. Among all the isolates, eurylene ...
Source: Fitoterapia - August 30, 2023 Category: Biochemistry Authors: Youmin Ying Shubao Tu Jiayue Ni Xuejun Lu Xiaoyan Hu Panyi Lei Xingnuo Li Ying Wang Guoqian Jin Hong Wang Source Type: research
5-Hydroxymethylfurfural Ameliorates Allergic Inflammation in HMC-1 Cells by Inactivating NF- κB and MAPK Signaling Pathways
Biochem Genet. 2023 Aug 30. doi: 10.1007/s10528-023-10492-9. Online ahead of print.ABSTRACTAllergic inflammation is the foundation of multiple allergic disorders, such as allergic rhinitis and asthma. Mast cells are effector cells that initiate inflammatory response. 5-hydroxymethylfurfural (5-HMF), a furfural compound, is the heat-processed product of various fruit, foods, drinks, as well as some Chinese herbal medicines. 5-HMF was previously reported to inhibit mast cell activation. Our study aimed to explore the functions of 5-HMF in both phorbol 12-mystate 13-acetate (PMA) plus calcium ionophore (A23187)-induced allerg...
Source: Biochemical Genetics - August 30, 2023 Category: Genetics & Stem Cells Authors: Pan Hu Zhuo Zhang Xiaolin Yu Yinglin Wang Source Type: research
Antidiabetic and antioxidant properties of Paeonia mascula L.: In vitro and in vivo studies, and phytochemical analysis
This study aimed to investigate the in vitro α-glucosidase enzyme inhibition effect, in vivo antidiabetic, and antioxidant activities of extracts obtained from P. mascula. The in vivo studies were conducted on diabetic rats induced with streptozotocin. The ethyl acetate and n-butanol extracts showed the highest efficacy in both in vitro and in vivo experiments, reducing AST, ALT, and MDA levels while increasing GSH and SOD activities in rats. In total, seven compounds were isolated from both extracts, and their structures were identified using spectroscopic methods such as 1D and 2D NMR and Mass Spectrometry. The in vitro...
Source: Fitoterapia - August 30, 2023 Category: Biochemistry Authors: Sefa G özcü Rustem Anil Ugan Hilal Özbek Bet ül Gündoğdu Zuhal Guvenalp Source Type: research
An insight of naturally occurring phytoconstituents and novel approaches towards the treatment of diabetes
CONCLUSION: Conventional or synthetic drugs provide relief for short time but nanoformulations of phytomolecules offer an improved therapeutic with fewer negative side effects. Herbal medicines are rich in phytoconstituents and possess variety of health benefits. This review is compilation of phytoconstituents and novel drug delivery system of phytomolecules i.e nanoparticles, niosomes, microsphere, microparticle and others.PMID:37644751 | DOI:10.2174/1573399820666230829094724
Source: Current Diabetes Reviews - August 30, 2023 Category: Endocrinology Authors: Zulfa Nooreen Awani Kumar Rai Fariha Summayya Sudeep Tandon Source Type: research
Types of Nursing Intervention on Improving Quality of Life among Patients with Diabetes Mellitus: A Systematic Review
CONCLUSION: Sequentially, the most common types of nursing interventions to improve the QoL of DM patients was health education, followed by exercise, WA/SMS gateway, and glucose control. A personal approach to health education is a significant point in improving the QoL of DM patients in the future. The findings of this study might not be strongly generalized, so further randomized controlled trial (RCT) studies with larger samples are needed.PMID:37644750 | DOI:10.2174/1573399820666230829103016
Source: Current Diabetes Reviews - August 30, 2023 Category: Endocrinology Authors: Agung Samsu Alam Amin Samiasih Fatkul Mubin Satriya Pranata Reina Dhamanik Source Type: research
Avicularin alleviates acute liver failure by regulation of the TLR4/MyD88/NF- κB and Nrf2/HO-1/GPX4 pathways to reduce inflammation and ferroptosis
J Cell Mol Med. 2023 Aug 29. doi: 10.1111/jcmm.17905. Online ahead of print.ABSTRACTAcute liver failure (ALF) is an inflammation-mediated hepatocyte death process associated with ferroptosis. Avicularin (AL), a Chinese herbal medicine, exerts anti-inflammatory and antioxidative effects. However, the protective effect of AL and the mechanism on ALF have not been reported. Our in vivo results suggest that AL significantly alleviated lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced hepatic pathological injury, liver enzymes, inflammatory cytokines, reactive oxygen species and iron levels and increased the antioxidant...
Source: J Cell Mol Med - August 30, 2023 Category: Molecular Biology Authors: Pei Shi Wentao Zhu Jiwei Fu An Liang Ting Zheng Zhilong Wen Xincheng Wu Yuchen Peng Songsong Yuan Xiaoping Wu Source Type: research
