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Insights into forsythia honeysuckle (Lianhuaqingwen) capsules: A Chinese herbal medicine repurposed for COVID-19 pandemic
CONCLUSION: This review summarizes the available reports and evidence that support the use of LH capsules as potential drug candidates for the prevention and treatment of COVID-19. However, TCM exerts its effects through multiple targets and multiple pathways, and LH capsules are not an exception. Therefore, the relevant mechanisms need to be further improved and experimentally verified.PMID:35399819 | PMC:PMC7833308 | DOI:10.1016/j.phyplu.2021.100027
Source: Herpes - April 11, 2022 Category: Infectious Diseases Authors: Chengyuan Liang Nan Hui Yuzhi Liu Guaiping Qiao Juan Li Lei Tian Xingke Ju Minyi Jia Hong Liu Wenqiang Cao Pengcheng Yu Han Li Xiaodong Ren Source Type: research

Studies on Activities and Chemical Characterization of Medicinal Plants in Search for New Antimalarials: A Ten Year Review on Ethnopharmacology
Malaria is an endemic disease that affected 229 million people and caused 409 thousand deaths, in 2019. Disease control is based on early diagnosis and specific treatment with antimalarial drugs since no effective vaccines are commercially available to prevent the disease. Drug chemotherapy has a strong historical link to the use of traditional plant infusions and other natural products in various cultures. The research based on such knowledge has yielded two drugs in medicine: the alkaloid quinine from Cinchona species, native in the Amazon highland rain forest in South America, and artemisinin from Artemisia annua, a spe...
Source: Frontiers in Pharmacology - September 22, 2021 Category: Drugs & Pharmacology Source Type: research

Computational search for potential COVID-19 drugs from FDAapproved drugs and small molecules of natural origin identifies several anti-virals and plant products.
Abstract The world is currently facing the COVID-19 pandemic, for which mild symptoms include fever and dry cough. In severe cases, it could lead to pneumonia and ultimately death in some instances. Moreover, the causative pathogen is highly contagious and there are no drugs or vaccines for it yet. The pathogen, SARS-CoV-2, is one of the human coronaviruses which was identified to infect humans first in December 2019. SARS-CoV-2 shares evolutionary relationship to other highly pathogenic viruses such as Severe Acute Respiratory Syndrome (SARS) and Middle East respiratory syndrome (MERS). We have exploited this sim...
Source: Journal of Biosciences - July 29, 2020 Category: Biomedical Science Authors: Sharma A, Tiwari V, Sowdhamini R Tags: J Biosci Source Type: research

Novel Stem Cells and Nucleic Acid-Based Vaccine Trials Against Viral Outbreak: A Systematic Evaluation During COVID-2019 Pandemic
AbstractThe current Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak, the cause of coronavirus disease (COVID-19), has influenced health globally. So far, there are no established management options and prophylaxis for those who have been exposed to SARS-CoV-2, and those who develop COVID-19. Documented scientific evidences in similar viral outbreaks in past suggested few therapy regimens. These rather have not shown promising results in management of current pandemic. So, in the current review, we are exploring novel treatment strategies and therapies that are being explored and are in clinical and pr...
Source: Indian Journal of Clinical Biochemistry - July 9, 2020 Category: Biochemistry Source Type: research

The impact of traditional plants and their secondary metabolites in the discovery of COVID-19 treatment.
CONCLUSION: The present review has listed plants that have presented antiviral potential in the previous coronavirus pandemics and their secondary metabolites which could be significant for the development of novel and a safer drug which could prevent and cure coronavirus infection worldwide. PMID: 33213320 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - November 17, 2020 Category: Drugs & Pharmacology Authors: Bibi S, Sarfraz A, Mustafa G, Ahmed Z, Zeb MA, Wang YB, Khan T, Khan MS, Kamal MA, Yu H Tags: Curr Pharm Des Source Type: research

COVID-19 Pandemic: A Case for Phytomedicines
Nat Prod Commun. 2020 Aug 14;15(8):1934578X20945086. doi: 10.1177/1934578X20945086. eCollection 2020 Aug.ABSTRACTCoronavirus disease 2019 (COVID-19) is an infection caused by a newly discovered coronavirus which was identified in Wuhan, China. The race is on globally to repurpose drugs for COVID-19 and develop a safe and effective vaccine against the disease. There is an urgent need to search for effective remedies against COVID-19 from the rich and extensive flora of Africa and the world. A literature search was conducted to obtain information on drugs with the potential for effectiveness in the treatment of COVID-19 base...
Source: Natural Product Communications - June 30, 2021 Category: Biochemistry Authors: ACEDHARS UNILAG COVID-19 Response Team Abidemi J Akindele Foluso O Agunbiade Margaret O Sofidiya Olufunsho Awodele Abimbola Sowemimo Omobolanle Ade-Ademilua Moshood O Akinleye Ismail O Ishola Ifeoma Orabueze Olumuyiwa B Salu Ibrahim A Oreagba Olayinka T A Source Type: research

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