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PRPF31-retinitis pigmentosa: Challenges and opportunities for clinical translation
Vision Res. 2023 Sep 13;213:108315. doi: 10.1016/j.visres.2023.108315. Online ahead of print.ABSTRACTMutations in pre-mRNA processing factor 31 cause autosomal dominant retinitis pigmentosa (PRPF31-RP), for which there is currently no efficient treatment, making this disease a prime target for the development of novel therapeutic strategies. PRPF31-RP exhibits incomplete penetrance due to haploinsufficiency, in which reduced levels of gene expression from the mutated allele result in disease. A variety of model systems have been used in the investigation of disease etiology and therapy development. In this review, we discu...
Source: Vision Research - September 15, 2023 Category: Opthalmology Authors: Hamzah Aweidah Zhouhuan Xi Jos é-Alain Sahel Leah C Byrne Source Type: research
Alterations of fecal microbiome and metabolome in pemphigus patients
J Autoimmun. 2023 Sep 13:103108. doi: 10.1016/j.jaut.2023.103108. Online ahead of print.ABSTRACTThe role of gut microbiome and metabolic substances in the development of autoimmune diseases has gradually been revealed. However, the relevant gut features in pemphigus have not been well clarified. We collected stool samples from pemphigus patients and healthy controls (HCs). Metagenomic sequencing and liquid chromatography-mass spectrometry (LC/MS) metabolome sequencing were performed to analyze the compositional and metabolic alternations of the gut microbiome in pemphigus patients and HCs. We observed the reduced richness ...
Source: Journal of Autoimmunity - September 15, 2023 Category: Allergy & Immunology Authors: Ziyu Guo Nam Yiu Zhi Hu Wenyu Zhou Xuan Long Miao Yang Jieyue Liao Guiying Zhang Qianjin Lu Ming Zhao Source Type: research
PRPF31-retinitis pigmentosa: Challenges and opportunities for clinical translation
Vision Res. 2023 Sep 13;213:108315. doi: 10.1016/j.visres.2023.108315. Online ahead of print.ABSTRACTMutations in pre-mRNA processing factor 31 cause autosomal dominant retinitis pigmentosa (PRPF31-RP), for which there is currently no efficient treatment, making this disease a prime target for the development of novel therapeutic strategies. PRPF31-RP exhibits incomplete penetrance due to haploinsufficiency, in which reduced levels of gene expression from the mutated allele result in disease. A variety of model systems have been used in the investigation of disease etiology and therapy development. In this review, we discu...
Source: Vision Research - September 15, 2023 Category: Opthalmology Authors: Hamzah Aweidah Zhouhuan Xi Jos é-Alain Sahel Leah C Byrne Source Type: research
Retinal microvasculature features in patients with migraine: a systematic review and meta-analysis
ConclusionMigraine patients are prone to retinal microcirculation disorders, such as decreased blood vessel density and increased avascular area in the fovea. This provides a theoretical basis for OCTA as a candidate for rapid, non-invasive diagnosis of migraine.
Source: Frontiers in Neurology - September 15, 2023 Category: Neurology Source Type: research
Honokiol Attenuates Choroidal Neovascularization by Inhibiting the Hypoxia-inducible Factor- α/Vascular Endothelial Growth Factor Axis via Nuclear transcription factor-kappa B Activation
CONCLUSION: We demonstrated that honokiol attenuated CNV formation by inactivating the HIF-1α/VEGF axis through NF-κB signaling pathway.PMID:37707827 | DOI:10.1080/02713683.2023.2259634
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Ningxin Pan Jian Shi Shu Du Zhaoxian Qiu Qiliang Ran Yangchen Guo Anping Ma Qi Zhang Aimin Sang Xiaowei Yang Source Type: research
Hydrogen Peroxide Affects the Electroretinogram of Isolated Perfused Rat Retina
CONCLUSIONS: H2O2 affects retinal function as shown by ERGs in isolated rat retina. The response differs with the dose of H2O2, suggesting that mechanisms underlying the action at low doses might be different from those at high doses. Our results also suggest an effect of H2O2 on ionic currents and/or neurotransmitter releases involved in the generation of the ERG and indicate a more pronounced effect on photoreceptors than on postsynaptic cells.PMID:37706511 | DOI:10.1080/02713683.2023.2256029
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Nathalie Jacquemot Eric Wersinger Philippe Brabet David Cia Source Type: research
Honokiol Attenuates Choroidal Neovascularization by Inhibiting the Hypoxia-inducible Factor- α/Vascular Endothelial Growth Factor Axis via Nuclear transcription factor-kappa B Activation
CONCLUSION: We demonstrated that honokiol attenuated CNV formation by inactivating the HIF-1α/VEGF axis through NF-κB signaling pathway.PMID:37707827 | DOI:10.1080/02713683.2023.2259634
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Ningxin Pan Jian Shi Shu Du Zhaoxian Qiu Qiliang Ran Yangchen Guo Anping Ma Qi Zhang Aimin Sang Xiaowei Yang Source Type: research
Hydrogen Peroxide Affects the Electroretinogram of Isolated Perfused Rat Retina
CONCLUSIONS: H2O2 affects retinal function as shown by ERGs in isolated rat retina. The response differs with the dose of H2O2, suggesting that mechanisms underlying the action at low doses might be different from those at high doses. Our results also suggest an effect of H2O2 on ionic currents and/or neurotransmitter releases involved in the generation of the ERG and indicate a more pronounced effect on photoreceptors than on postsynaptic cells.PMID:37706511 | DOI:10.1080/02713683.2023.2256029
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Nathalie Jacquemot Eric Wersinger Philippe Brabet David Cia Source Type: research
Protective effect of dietary micronutrients on gastric cancer risk among Jordanians
CONCLUSIONS: our data support favorable effects of dietary consumption of some vitamins and minerals against GC risk.PMID:37705441 | DOI:10.20960/nh.04547
Source: Nutricion Hospitalaria - September 14, 2023 Category: Nutrition Authors: Sabika Allehdan Shatha S Hammad Razan M Alatrash Tareq Al-Jaberi Ahmad Hushki Shirin Yacoub Mohammad Dahoud Tahra Elobeid Reema Tayyem Tayyem Source Type: research
Hyperbaric oxygen treatment for paracentral acute middle maculopathy: a case study
Undersea Hyperb Med. 2023 Third Quarter;50(3):283-287.ABSTRACTA 47-year-old active-duty Navy diver with a complicated past medical history which resulted in his designation as not physically qualified (NPQ) for diving duty in 2016 presented on 07 May 2021 complaining of left-sided blurred vision. On exam by the attending undersea medical officer, he was found to have a left upper inner and upper outer quadrant visual field defect and a central scotoma. Urgent referral to ophthalmology ruled out retinal detachment but resulted in an initial diagnosis of a left branch retinal artery occlusion without embolus. Considering thi...
Source: Undersea and Hyperbaric Medicine - September 14, 2023 Category: Sports Medicine Authors: Robert J Neiberger Edward T Waters Source Type: research
Hyperbaric oxygen therapy for central retinal artery occlusion: Visual acuity and time to treatment
CONCLUSIONS: HBO2 may be an effective treatment for non-arteritic CRAO, especially if patients are treated early and present with salvageable vision. The time to treatment and the presenting visual acuity may be predictive factors on the visual prognosis following HBO2. Further studies with a prospective design and more patients are necessary to determine the long-term outcomes and the optimal protocol for HBO2 in CRAO patients.PMID:37708058
Source: Undersea and Hyperbaric Medicine - September 14, 2023 Category: Sports Medicine Authors: Deidre St Peter David Na Kinjal Sethuraman Michaela Kunz Mathews Albert S Li Source Type: research
