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Ocular manifestations of COVID-19: a systematic review and meta-analysis
CONCLUSION: COVID-19 can exhibit extrapulmonary manifestations, affecting both the anterior and posterior segments of the eye. Common anterior-segment findings include conjunctivitis, whereas posterior-segment findings may include cotton wool spots, retinal hemorrhages, and retinal vein tortuosity. Improving our understanding of the ocular manifestations of COVID-19 has the potential to facilitate quicker diagnosis and subsequent treatment.PMID:37683691 | DOI:10.1016/j.jcjo.2023.08.003
Source: Canadian Journal of Ophthalmology - September 8, 2023 Category: Opthalmology Authors: Edward Tran Vivian Phu Riley Xu Angela Teoderascu Mohamed Aly Nirmit Shah Monali S Malvankar-Mehta Source Type: research
Elucidating anti-aging and antioxidant activity of Hydnocarpus anthelmintica on skin aging and cosmeceutical potentials: in silico and in vitro study
CONCLUSION: The results of in-vitro experiments showed the effect of HA extract on oxidative stress reduction and collagenase inhibition. We discovered two main active compounds, luteolin and β-carotene, that may be involved in p53 and MAPK signaling, and showed HA extract activity against oxidative stress and collagenase.PMID:37680148 | DOI:10.2174/1386207326666230901092247
Source: Combinatorial Chemistry and High Throughput Screening - September 8, 2023 Category: Chemistry Authors: Minjee Kim Eunji Lee Young Bong Kim Source Type: research
Ocular manifestations of COVID-19: a systematic review and meta-analysis
CONCLUSION: COVID-19 can exhibit extrapulmonary manifestations, affecting both the anterior and posterior segments of the eye. Common anterior-segment findings include conjunctivitis, whereas posterior-segment findings may include cotton wool spots, retinal hemorrhages, and retinal vein tortuosity. Improving our understanding of the ocular manifestations of COVID-19 has the potential to facilitate quicker diagnosis and subsequent treatment.PMID:37683691 | DOI:10.1016/j.jcjo.2023.08.003
Source: Canadian Journal of Ophthalmology - September 8, 2023 Category: Opthalmology Authors: Edward Tran Vivian Phu Riley Xu Angela Teoderascu Mohamed Aly Nirmit Shah Monali S Malvankar-Mehta Source Type: research
Elucidating anti-aging and antioxidant activity of Hydnocarpus anthelmintica on skin aging and cosmeceutical potentials: in silico and in vitro study
CONCLUSION: The results of in-vitro experiments showed the effect of HA extract on oxidative stress reduction and collagenase inhibition. We discovered two main active compounds, luteolin and β-carotene, that may be involved in p53 and MAPK signaling, and showed HA extract activity against oxidative stress and collagenase.PMID:37680148 | DOI:10.2174/1386207326666230901092247
Source: Combinatorial Chemistry and High Throughput Screening - September 8, 2023 Category: Chemistry Authors: Minjee Kim Eunji Lee Young Bong Kim Source Type: research
M üller cell vulnerability in aging human retina: Implications on photoreceptor cell survival
This study examined age-related changes in MC of donor human retina (age: 35-98 years; N = 18 donors). Ultrastructural and immunohistochemical observations indicate that MC undergo gliosis and increased lipid peroxidation, and show osmotic changes with advanced aging (>80 years). Photoreceptor cells also undergo oxidative-nitrosative stress with aging, and their synapses also show clear osmotic swelling. MC respond to oxidative stress via proliferation of smooth endoplasmic reticulum in their processes, and increased expression of aquaporin-4 in endfeet and outer retina. In advanced aged retinas (81-98 years), they show...
Source: Experimental Eye Research - September 8, 2023 Category: Opthalmology Authors: Tapas C Nag Source Type: research
Ocular manifestations of COVID-19: a systematic review and meta-analysis
CONCLUSION: COVID-19 can exhibit extrapulmonary manifestations, affecting both the anterior and posterior segments of the eye. Common anterior-segment findings include conjunctivitis, whereas posterior-segment findings may include cotton wool spots, retinal hemorrhages, and retinal vein tortuosity. Improving our understanding of the ocular manifestations of COVID-19 has the potential to facilitate quicker diagnosis and subsequent treatment.PMID:37683691 | DOI:10.1016/j.jcjo.2023.08.003
Source: Canadian Journal of Ophthalmology - September 8, 2023 Category: Opthalmology Authors: Edward Tran Vivian Phu Riley Xu Angela Teoderascu Mohamed Aly Nirmit Shah Monali S Malvankar-Mehta Source Type: research
Clinical features of infectious uveitis in a Tunisian population
CONCLUSION: This study highlighted the causes and clinical features of IU in our setting. Tuberculosis remains one of its most frequent etiologies in Tunisia. However, a larger multicenter national study would allow a more precise evaluation.PMID:37682270
Source: Herpes - September 8, 2023 Category: Infectious Diseases Authors: Rym Maamouri Meriam Beldi Yasmine Houman Mehdi Somai Fatma Boussema Monia Cheour Source Type: research
Ocular manifestations of COVID-19: a systematic review and meta-analysis
CONCLUSION: COVID-19 can exhibit extrapulmonary manifestations, affecting both the anterior and posterior segments of the eye. Common anterior-segment findings include conjunctivitis, whereas posterior-segment findings may include cotton wool spots, retinal hemorrhages, and retinal vein tortuosity. Improving our understanding of the ocular manifestations of COVID-19 has the potential to facilitate quicker diagnosis and subsequent treatment.PMID:37683691 | DOI:10.1016/j.jcjo.2023.08.003
Source: Canadian Journal of Ophthalmology - September 8, 2023 Category: Opthalmology Authors: Edward Tran Vivian Phu Riley Xu Angela Teoderascu Mohamed Aly Nirmit Shah Monali S Malvankar-Mehta Source Type: research
Cis-urocanic acid improves cell viability and suppresses inflammasome activation in human retinal pigment epithelial cells
This study indicates that due to its beneficial properties of preserving cell viability and preventing inflammation, cis-UCA has potential in drug development of chronic ocular diseases, such as AMD.PMID:37683842 | DOI:10.1016/j.bcp.2023.115790
Source: Biochemical Pharmacology - September 8, 2023 Category: Drugs & Pharmacology Authors: Eveliina Korhonen Niina Piippo Maria Hytti Kai Kaarniranta Anu Kauppinen Source Type: research
Ocular manifestations of COVID-19: a systematic review and meta-analysis
CONCLUSION: COVID-19 can exhibit extrapulmonary manifestations, affecting both the anterior and posterior segments of the eye. Common anterior-segment findings include conjunctivitis, whereas posterior-segment findings may include cotton wool spots, retinal hemorrhages, and retinal vein tortuosity. Improving our understanding of the ocular manifestations of COVID-19 has the potential to facilitate quicker diagnosis and subsequent treatment.PMID:37683691 | DOI:10.1016/j.jcjo.2023.08.003
Source: Canadian Journal of Ophthalmology - September 8, 2023 Category: Opthalmology Authors: Edward Tran Vivian Phu Riley Xu Angela Teoderascu Mohamed Aly Nirmit Shah Monali S Malvankar-Mehta Source Type: research
Intravitreal immunotherapy in noninfectious uveitis: an update
Expert Rev Clin Pharmacol. 2023 Sep 6. doi: 10.1080/17512433.2023.2256660. Online ahead of print.ABSTRACTINTRODUCTION: In the past several years, there have been numerous advances in pharmacotherapeutics for the management of uveitis and other ocular inflammatory diseases, including newer therapeutic agents and ocular drug delivery systems. One of the most attractive modes of drug delivery is the intravitreal route since it has proven to be safe and efficacious and prevents unwanted systemic adverse events related to the agent.AREAS COVERED: In this review, intravitreal delivery of various pharmacotherapeutic agents for no...
Source: Pharmacological Reviews - September 7, 2023 Category: Drugs & Pharmacology Authors: Nitin Kumar Menia Sashwanthi Mohan Aniruddha Agarwal Source Type: research
Retinal vein occlusion following BNT162b2 (Pfizer-BioNTech) COVID-19 vaccination
Singapore Med J. 2023 Aug 22. doi: 10.4103/singaporemedj.SMJ-2021-430. Online ahead of print.NO ABSTRACTPMID:37675679 | DOI:10.4103/singaporemedj.SMJ-2021-430
Source: Singapore Medical Journal - September 7, 2023 Category: General Medicine Authors: Duoduo Wu Blanche Xiao Hong Lim Dawn Ka-Ann Lim Gopal Lingam Chris Hong Long Lim Source Type: research
Application of IPSC and M üller glia derivatives in retinal degenerative diseases
Prog Mol Biol Transl Sci. 2023;199:351-362. doi: 10.1016/bs.pmbts.2023.03.026. Epub 2023 Apr 27.ABSTRACTRetinal degenerative diseases cause blindness characterized by a progressive decline in the number and function of retinal pigment epithelium (RPE), photoreceptor cells, and ganglion cells. Such diseases include retinitis pigmentosa (RP), glaucomatous optic neuropathy, age-related macular degeneration and diabetic optic neuropathy. Recent studies have demonstrated that Müller glial cells (MGCs), an endogenous alternative source of retinal neurons, are important glial cells involved in retinal development, damage, and re...
Source: Mol Biol Cell - September 7, 2023 Category: Molecular Biology Authors: Guoge Han Pinghui Wei Quanhong Han Source Type: research
