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Therapy: Immunotherapy
Nutrition: Probiotics
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Total 147 results found since Jan 2013.
Intratumoral Bacteria as Mediators of Cancer Immunotherapy Response
Cancer Res. 2023 Sep 15;83(18):2985-2986. doi: 10.1158/0008-5472.CAN-23-1857.ABSTRACTMultiple lines of evidence spanning from animal models to human clinical trials indicate that the microbiome influences cancer immunotherapy response. Whereas initial studies focused exclusively on the gastrointestinal (gut) microbiota-tumor axis, more recent studies have examined the possibility that bacteria located within tumor cells or within the tumor microenvironment mediate cancer treatment response. Strikingly, this phenomenon has been demonstrated in cancers that arise in anatomic locations that are traditionally thought to be dev...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Karen S Sfanos Source Type: research
Faecalibacterium prausnitzii abrogates intestinal toxicity and promotes tumor immunity to increase the efficacy of dual CTLA-4 and PD-1 checkpoint blockade
Cancer Res. 2023 Aug 21:CAN-23-0605. doi: 10.1158/0008-5472.CAN-23-0605. Online ahead of print.ABSTRACTImmune checkpoint inhibitors (ICIs) have revolutionized cancer therapy; however, their application is limited by the occurrence of immune-related adverse events. The gut microbiota plays important roles in the response to and toxicity of immunotherapy, and Faecalibacterium prausnitzii (F. prausnitzii) has been shown to possess immunomodulatory potential. Here, we found that patients receiving ICIs who developed colitis had a lower abundance of F. prausnitzii. In vivo, immunocompetent mice administered with dextran sodium ...
Source: Cell Research - August 21, 2023 Category: Cytology Authors: Yaqi Gao Pingping Xu Danfeng Sun Yi Jiang Xiaolin Lin Ting Han Jun Yu Chunquan Sheng Hao-Yan Chen Jie Hong Yingxuan Chen Xiu-Ying Xiao Jing-Yuan Fang Source Type: research
Therapeutic and immunomodulatory role of probiotics in breast cancer: A mechanistic review
Arch Microbiol. 2023 Jul 24;205(8):296. doi: 10.1007/s00203-023-03632-7.ABSTRACTBreast cancer has become the most prevalent and noxious type of malignancy around the globe (Giaquinto et al., 2022). Multiple clinical strategies including chemotherapy, radiotherapy, and immunotherapy have been in practice to manage breast cancer. Besides the protective roles of conventional remedial approaches, and non-reversible and deteriorative impacts like healthy cell damage, organ failure, etc., the world scientific community is in a continuous struggle to find some alternative biocompatible and comparatively safe solutions. Among nove...
Source: Archives of Microbiology - July 24, 2023 Category: Microbiology Authors: Muhammad Summer Shaukat Ali Umaima Fiaz Hafiz Muhammad Tahir Muhammad Ijaz Shumaila Mumtaz Rabia Mushtaq Rida Khan Hafsa Shahzad Hashim Fiaz Source Type: research
Soluble CD80 oral delivery by recombinant Lactococcus suppresses tumor growth by enhancing antitumor immunity
In this study, we aimed to construct recombinant Lactococcus lactis for oral delivery of the soluble CD80 (hsCD80) protein or the fusion protein containing the cholera toxin B subunit (CTB) and hsCD80 (CTB-hsCD80) under the control of the nisin-inducible expression system. The recombinant L. lactis expressed and secreted hsCD80 or CTB-hsCD80 fusion proteins after induction by nisin in vitro and in the enteric cavity. Additionally, the CTB-hsCD80 fusion protein showed uptake by intestinal epithelial cells, was cleaved by the furin protease, and was released as free hsCD80 protein into the blood circulation. Orally administe...
Source: Cancer Control - July 21, 2023 Category: Cancer & Oncology Authors: Ziqing Lin Yanqing Tang Zerong Chen Simin Li Xueyan Xu Xufeng Hou Zhenhui Chen Junjie Wen Weisen Zeng Xiaojing Meng Hongying Fan Source Type: research
Updates in the diagnosis and practical management of allergic rhinitis
Expert Rev Clin Pharmacol. 2023 Jun 14. doi: 10.1080/17512433.2023.2225770. Online ahead of print.ABSTRACTINTRODUCTION: Allergic rhinitis (AR) is a widespread disease that can be associated with other conditions, including conjunctivitis, rhinosinusitis, asthma, food allergy and atopic dermatitis. Diagnosis is based on history and documentation of sensitization, such as the production of allergen-specific IgE, preferably using molecular diagnostics. Treatments are based on patient education, non-pharmacological and pharmacological remedies, allergen-specific immunotherapy (AIT), and surgery. Symptomatic treatments mainly c...
Source: Pharmacological Reviews - June 14, 2023 Category: Drugs & Pharmacology Authors: Chiara Trincianti Maria Angela Tosca Giorgio Ciprandi Source Type: research
Exploring the complex and multifaceted interplay of the gut microbiome and cancer prevention and therapy
Acta Microbiol Immunol Hung. 2023 Jun 12;70(2):85-99. doi: 10.1556/030.2023.02054. Print 2023 Jun 16.ABSTRACTRecent scientific research has indicated that the gut microbiota constitutes a nuanced, diverse ecosystem of microorganisms that have gained significant attention due to its crucial involvement in shaping human health and diseases. In particular, the gut microbiota plays a pivotal role in cancer prevention, and disturbances in its composition and function, known as dysbiosis, that have been linked to an increased risk of developing various malignancies. The gut microbiota exerts a myriad of effects on the production...
Source: Acta Microbiologica et Immunologica Hungarica - June 12, 2023 Category: Microbiology Authors: Sukrit Kashyap Asmita Das Source Type: research
A narrative review from gut to lungs: non-small cell lung cancer and the gastrointestinal microbiome
CONCLUSIONS: A strong relationship exists between gut microbiome, oncogenesis, and anticancer immunity. Although the underlying mechanisms are poorly understood, immunotherapy outcomes seem to depend on host-related factors such as gut microbiome alpha diversity, relative abundance of microbial genera/taxa, and extrinsic factors such as prior or concurrent exposure to probiotics, antibiotics, and other microbiome-modifying drugs.PMID:37197624 | PMC:PMC10183407 | DOI:10.21037/tlcr-22-595
Source: Cell Research - May 17, 2023 Category: Cytology Authors: Hely Shah Terry L Ng Source Type: research
Role of the Microbiome in Immunotherapy of Melanoma
This article also highlights the emerging frontier of artificial intelligence in its application regarding patient microbial composition evaluation, predictive models for therapy response, and recommendations for the future of probiotics and dietary interventions to optimize melanoma survival and outcomes.PMID:36957976 | DOI:10.1097/PPO.0000000000000648
Source: Cancer Journal - March 23, 2023 Category: Cancer & Oncology Authors: Victoria Jiminez Nabiha Yusuf Source Type: research
