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Electrochemical Radiofluorination of Small Molecules: New Advances
Chem Rec. 2021 May 19. doi: 10.1002/tcr.202100086. Online ahead of print.ABSTRACTThe development of new 18 F-based radiopharmaceuticals constantly demands innovations in the search for new radiofluorination methods. [18 F]fluoride is the simplest and most convenient chemical form of the isotope for the synthesis of 18 F-based radiopharmaceuticals. The ease of production and handling, as well as the possibility of obtaining high molar activities, makes it the preferred choice for radiofluorination. However, the use of [18 F]fluoride in late-stage radiofluorination comes with challenges, especially for the radiolabeling of e...
Source: Chemical Record - May 19, 2021 Category: Chemistry Authors: Daniel Hern ández-Valdés Saman Sadeghi Source Type: research
Integrating bioavailability and aging in the criteria derivation of cadmium for the safe production of rice in paddy soils
In conclusion, this study provided valuable and scientific bases for setting soil Cd criteria for paddy soils.PMID:34044309 | DOI:10.1016/j.ecoenv.2021.112356
Source: Ecotoxicology and Environmental Safety - May 27, 2021 Category: Environmental Health Authors: Lijun Li Bao Jiang Yanan Wan Jumei Li Yibing Ma Source Type: research
Molecules, Vol. 26, Pages 3320: Synthesis and Neurotropic Activity of New Heterocyclic Systems: Pyridofuro3,2-dpyrrolo1,2-apyrimidines, Pyridofuro3,2-dpyrido1,2-apyrimidines and Pyridofuro3 ′,2′:4,5pyrimido1,2-aazepines
Conclusions: Тhe selected compounds have an anticonvulsant, activating behavior and anxiolytic effects, at the same time exhibit some antidepressant effect.
Source: Molecules - June 1, 2021 Category: Chemistry Authors: Samvel N. Sirakanyan Domenico Spinelli Athina Geronikaki Victor Kartsev Elmira K. Hakobyan Anthi Petrou Ruzanna G. Paronikyan Ivetta M. Nazaryan Hasmik H. Akopyan Anush A. Hovakimyan Tags: Article Source Type: research
Background exposure to polychlorinated biphenyls and all-cause, cancer-specific, and cardiovascular-specific mortality: A systematic review and meta-analysis
CONCLUSION: Our meta-analysis suggests that background exposure to PCBs is associated with an increased risk of cardiovascular-specific mortality in the general population with a "moderate" level of evidence. These findings should be interpreted with caution given the small number of studies on mortality in the general population.PMID:34082240 | DOI:10.1016/j.envint.2021.106663
Source: Environment International - June 3, 2021 Category: Environmental Health Authors: Thibault Fiolet Yahya Mahamat-Saleh Pauline Frenoy Marina Kvaskoff Francesca Romana Mancini Source Type: research
The Genetics of Adverse Drug Outcomes in Type 2 Diabetes: A Systematic Review
Conclusion: In spite of limited studies investigating genetics and ADR in diabetes, some convincing results are emerging. Genetic variants in genes encoding drug transporters and metabolizing enzymes are implicated in metformin-related GI adverse effects, and sulfonylurea-induced hypoglycemia, respectively. Further studies to investigate newer antidiabetic drugs such as DPP-4i, GLP-1RA, and SGLT2i are warranted. In addition, pharmacogenetic studies that account for race and ethnic differences are required.
Source: Frontiers in Genetics - June 14, 2021 Category: Genetics & Stem Cells Source Type: research
A review: Pharmacological aspects of metal based 1,2,4-triazole derived Schiff bases
Eur J Med Chem. 2021 Jun 6;222:113602. doi: 10.1016/j.ejmech.2021.113602. Online ahead of print.ABSTRACTClinical reports have highlighted the radical increase of antibiotic resistance. As a result, multidrug resistance has emerged as a serious threat to human health. Many organic compounds commonly used as drugs in the past, no longer have pure organic mode of action rather need bio-transformation or more activation. Bulk of research has shown that they need trace amount of metal ions incorporated within the chemistry of bioactive molecules for enhancement of their potentiality to fight aggressively against resistance. The...
Source: European Journal of Medicinal Chemistry - June 17, 2021 Category: Chemistry Authors: Wardha Zafar Sajjad H Sumrra Zahid H Chohan Source Type: research
Novel fleximer pyrazole-containing adenosine analogues: chemical, enzymatic and highly-efficient biotechnological synthesis
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB01069G, PaperAnastasia Khandazhinskaya, Barbara Z. Eletskaya, Ilja V. Fateev, Maria I. Kharitonova, Irina Konstantinova, Vladimir Baray, Alex Azhayev, Mervi T Hyvonen, Tuomo A Keinanen, Sergey N. Kochetkov, Katherine L Seley-Radtke, Alex Khomutov, Elena Matyugina Nucleoside analogues have long served as key chemotherapeutic drugs for treatment of viral infections and cancers. Problems associated with the development of drug resistance has led to a search for... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - June 19, 2021 Category: Molecular Biology Authors: Anastasia Khandazhinskaya Source Type: research
A review: Pharmacological aspects of metal based 1,2,4-triazole derived Schiff bases
Eur J Med Chem. 2021 Jun 6;222:113602. doi: 10.1016/j.ejmech.2021.113602. Online ahead of print.ABSTRACTClinical reports have highlighted the radical increase of antibiotic resistance. As a result, multidrug resistance has emerged as a serious threat to human health. Many organic compounds commonly used as drugs in the past, no longer have pure organic mode of action rather need bio-transformation or more activation. Bulk of research has shown that they need trace amount of metal ions incorporated within the chemistry of bioactive molecules for enhancement of their potentiality to fight aggressively against resistance. The...
Source: European Journal of Medicinal Chemistry - June 17, 2021 Category: Chemistry Authors: Wardha Zafar Sajjad H Sumrra Zahid H Chohan Source Type: research
Fatigue as the Chief Complaint-Epidemiology, Causes, Diagnosis, and Treatment
CONCLUSION: The work-up of fatigue as a chief complaint should be guided by investigating common and/or potentially dangerous disorders. Since the latter are rare, an exclusively somatic focus should be avoided in order to prevent overdiagnosis.PMID:34196270 | DOI:10.3238/arztebl.m2021.0192
Source: Deutsches Arzteblatt International - July 1, 2021 Category: General Medicine Authors: Peter Maisel Erika Baum Norbert Donner-Banzhoff Source Type: research
