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Total 38 results found since Jan 2013.

Proteomic characterization of Opisthorchis felineus exosome-like vesicles and their uptake by human cholangiocytes
J Proteomics. 2023 May 22:104927. doi: 10.1016/j.jprot.2023.104927. Online ahead of print.ABSTRACTThe epidemiologically important food-borne trematode Opisthorchis felineus infests the liver biliary tract of fish-eating mammals and causes disorders, including bile duct neoplasia. Many parasitic species release extracellular vesicles (EVs) that mediate host-parasite interaction. Currently, there is no information on O. felineus EVs. Using gel electrophoresis followed by liquid chromatography coupled with tandem mass spectrometry, we aimed to characterize the proteome of EVs released by the adult O. felineus liver fluke. Dif...
Source: Journal of Proteomics - May 24, 2023 Category: Biochemistry Authors: Maria Y Pakharukova Ekaterina Savina Dmitry V Ponomarev Natalya V Gubanova Oxana Zaparina Elvira G Zakirova Guofeng Cheng Olga V Tikhonova Viatcheslav A Mordvinov Source Type: research

Fight Aging! Newsletter, April 24th 2023
In this study, researchers show that mice lacking a functional ATF4 gene show little to no loss of grip strength and treadmill performance into late life; it is quite an impressive effect size. Assessments of muscle biochemistry do show age-related declines, but to a lesser degree than the controls. How ATF4 knockout functions to produce this outcome is an interesting question. The researchers point out a range of possible downstream and upstream targets that have been implicated in the regulation of muscle growth, but it will clearly require further work to identify the important mechanisms involved. Aging slowly...
Source: Fight Aging! - April 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Progress Toward Global Eradication of Dracunculiasis - Worldwide, January 2021-June 2022
This report describes progress during January 2021-June 2022 and updates previous reports (2,4).PMID:36417302 | DOI:10.15585/mmwr.mm7147a2
Source: MMWR Morb Mortal Wkl... - November 23, 2022 Category: Epidemiology Authors: Donald R Hopkins Adam J Weiss Sarah Yerian Sarah G H Sapp Vitaliano A Cama Source Type: research

News at a glance: Webb telescope dinged, U.S.-Russia research paused, and NASA ’s UFO study
Table of contents A version of this story appeared in Science, Vol 376, Issue 6599. Download PDF ASTRONOMY Star mapper provides Milky Way portrait he European Space Agency’s Gaia satellite has now mapped almost 2 billion of the Milky Way’s stars, logging their positions, speeds, temperatures, and other parameters—and allowing astronomers to chart the Galaxy’s structure and evolution. Last week, operators released the third major trove of data, including lists of 800,000 binary stars, 10 million variable stars, and, within the Solar System, 156,000...
Source: Science of Aging Knowledge Environment - June 16, 2022 Category: Geriatrics Source Type: research

Leptospirosis: a growing health threat to fish farming and recreational activities
Ann Pharm Fr. 2022 Apr 25:S0003-4509(22)00039-6. doi: 10.1016/j.pharma.2022.04.003. Online ahead of print.ABSTRACTLeptospirosis is a cosmopolitan infectious disease caused by the bacteria Leptospira interrogans, which is worldwide increasing as the result of climate changes favoring the reproduction of asymptomatic reservoir rodents, and also of flooding that brings mammals and humans into contact with contaminated water. This disease affects many mammals among wild, domestic or farmed animals. In humans, it is manifested by frustrated to severe forms that can lead to liver and kidney failure and death in about one in ten ...
Source: Annales Pharmaceutiques Francaises - April 28, 2022 Category: Drugs & Pharmacology Authors: Philippe M Loiseau Mich èle German Source Type: research

Intranasal delivery of SARS-CoV-2 Spike protein is sufficient to cause olfactory damage, inflammation and olfactory dysfunction in zebrafish
Brain Behav Immun. 2022 Mar 17:S0889-1591(22)00074-5. doi: 10.1016/j.bbi.2022.03.006. Online ahead of print.ABSTRACTAnosmia, loss of smell, is a prevalent symptom of SARS-CoV-2 infection. Anosmia may be explained by several mechanisms driven by infection of non-neuronal cells and damage in the nasal epithelium rather than direct infection of olfactory sensory neurons (OSNs). Previously, viral proteins have been shown to be sufficient to cause neuroimmune responses in the olfactory organ (OO) by our group. We hypothesize that SARS-CoV-2 spike (S) protein is sufficient to cause olfactory damage and olfactory dysfunction. Usi...
Source: Brain, Behavior, and Immunity - March 21, 2022 Category: Neurology Authors: Aurora Kraus Mar Huertas Laura Ellis Pierre Boudinot Jean-Pierre Levraud Irene Salinas Source Type: research