• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Dysfunctional Cori and Krebs cycle and inhibition of lactate transporters constitute a mechanism of primary non-function of fatty liver allografts
Transl Res. 2023 Sep 16:S1931-5244(23)00146-9. doi: 10.1016/j.trsl.2023.09.006. Online ahead of print.ABSTRACTOrthotopic liver transplantation (OLT) is a lifesaving procedure. However, grafts may fail due to primary non-function (PNF). In the past, we demonstrated PNFs to be mainly associated with fatty allografts, and given its unpredictable nature, the development of a disease model is urgently needed. In an effort to investigate mechanism of fatty-allograft associated PNFs, we induced fatty liver disease in donor animals by feeding rats a diet deficient in methionine and choline (MCD). We performed OLT with allografts o...
Source: Translational Research : the journal of laboratory and clinical medicine - September 18, 2023 Category: Laboratory Medicine Authors: Ulf Kulik Caroline Moesta Reinhard Spanel J ürgen Borlak Source Type: research

Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Intratumoral Bacteria as Mediators of Cancer Immunotherapy Response
Cancer Res. 2023 Sep 15;83(18):2985-2986. doi: 10.1158/0008-5472.CAN-23-1857.ABSTRACTMultiple lines of evidence spanning from animal models to human clinical trials indicate that the microbiome influences cancer immunotherapy response. Whereas initial studies focused exclusively on the gastrointestinal (gut) microbiota-tumor axis, more recent studies have examined the possibility that bacteria located within tumor cells or within the tumor microenvironment mediate cancer treatment response. Strikingly, this phenomenon has been demonstrated in cancers that arise in anatomic locations that are traditionally thought to be dev...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Karen S Sfanos Source Type: research

Reviewing Evidence for Urolithin A Supplementation
Mitochondria are the power plants of the cell, responsible for generating chemical energy store molecules to power cell processes. Urolithin A is one of a number of supplements shown to improve mitochondrial function, though as for the others it isn't all that impressive when compared to the effects of regular exercise. Nonetheless, this and other approaches to modestly attenuate age-related declines in mitochondrial function are under active development. They are not solutions to the problem of mitochondrial aging, however. For that we must look to more radical approaches to therapy, such as mitochondrial transplantation,...
Source: Fight Aging! - September 14, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice
CONCLUSIONS: Our study demonstrated that IX prevents obesity and enhances glucose metabolism by inhibiting dietary fat absorption. This mechanism is linked to suppressing pancreatic lipase activity and shifts in microbial composition, notably an increase in A. muciniphila. These highlight new treatment strategies for preventing metabolic syndrome by boosting the gut microbiota with food components.PMID:37709134 | DOI:10.1016/j.molmet.2023.101797
Source: Molecular Medicine - September 14, 2023 Category: Molecular Biology Authors: Yoshiyuki Watanabe Shiho Fujisaka Yoshitomo Morinaga Shiro Watanabe Allah Nawaz Hideki Hatta Tomonobu Kado Ayumi Nishimura Muhammad Bilal Muhammad Rahil Aslam Keiko Honda Yoshimi Nakagawa Samir Softic Kenichi Hirabayashi Takashi Nakagawa Yoshinori Nagai K Source Type: research

Dual action of macrophage miR-204 confines cyclosporine A-induced atherosclerosis
Conclusion and implications Macrophage miR-204 ameliorates CsA-induced atherosclerosis, suggesting that miR-204 may be a potential target for the prevention and treatment of CsA-related atherosclerotic side effects.PMID:37702564 | DOI:10.1111/bph.16240
Source: Atherosclerosis - September 13, 2023 Category: Cardiology Authors: Jia-Hui Su Yu Hong Cong-Cong Han Jie Yu Xin Guan Ya-Mei Zhu Cheng Wang Ming-Ming Ma Rui-Ping Pang Jing-Song Ou Jia-Guo Zhou Zi-Yi Zhang Tao Ban Si-Jia Liang Source Type: research

Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations
Cell Metab. 2023 Sep 5;35(9):1530-1547.e8. doi: 10.1016/j.cmet.2023.08.002.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic dysfunction for which effective interventions are lacking. To investigate the effects of resistant starch (RS) as a microbiota-directed dietary supplement for NAFLD treatment, we coupled a 4-month randomized placebo-controlled clinical trial in individuals with NAFLD (ChiCTR-IOR-15007519) with metagenomics and metabolomics analysis. Relative to the control (n = 97), the RS intervention (n = 99) resulted in a 9.08% absolute reduction of intrahepatic triglyceride...
Source: Cell Metabolism - September 6, 2023 Category: Cytology Authors: Yueqiong Ni Lingling Qian Sara Leal Siliceo Xiaoxue Long Emmanouil Nychas Yan Liu Marsena Jasiel Ismaiah Howell Leung Lei Zhang Qiongmei Gao Qian Wu Ying Zhang Xi Jia Shuangbo Liu Rui Yuan Lina Zhou Xiaolin Wang Qi Li Yueliang Zhao Hani El-Nezami Aimin Xu Source Type: research

Gut microbiota-induced CXCL1 elevation triggers early neuroinflammation in the substantia nigra of Parkinsonian mice
This study may pave the way for understanding the "brain-gut-microbiota" molecular regulatory networks in PD pathogenesis. The aged C57BL/6 male mice with rotenone intragastric administration showed altered gut microbiota, which caused systemic inflammation, PPARγ signalling inhibition and neuroinflammation, brain iron deposition and ferroptosis, and eventually dopaminergic neurodegeneration in PD.PMID:37674043 | DOI:10.1038/s41401-023-01147-x
Source: Acta Pharmacologica Sinica - September 6, 2023 Category: Drugs & Pharmacology Authors: Xi-Zhen Ma Lei-Lei Chen Le Qu Hui Li Jun Wang Ning Song Jun-Xia Xie Source Type: research

Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations
Cell Metab. 2023 Sep 5;35(9):1530-1547.e8. doi: 10.1016/j.cmet.2023.08.002.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic dysfunction for which effective interventions are lacking. To investigate the effects of resistant starch (RS) as a microbiota-directed dietary supplement for NAFLD treatment, we coupled a 4-month randomized placebo-controlled clinical trial in individuals with NAFLD (ChiCTR-IOR-15007519) with metagenomics and metabolomics analysis. Relative to the control (n = 97), the RS intervention (n = 99) resulted in a 9.08% absolute reduction of intrahepatic triglyceride...
Source: Cell Metabolism - September 6, 2023 Category: Cytology Authors: Yueqiong Ni Lingling Qian Sara Leal Siliceo Xiaoxue Long Emmanouil Nychas Yan Liu Marsena Jasiel Ismaiah Howell Leung Lei Zhang Qiongmei Gao Qian Wu Ying Zhang Xi Jia Shuangbo Liu Rui Yuan Lina Zhou Xiaolin Wang Qi Li Yueliang Zhao Hani El-Nezami Aimin Xu Source Type: research

Gut microbiota-induced CXCL1 elevation triggers early neuroinflammation in the substantia nigra of Parkinsonian mice
This study may pave the way for understanding the "brain-gut-microbiota" molecular regulatory networks in PD pathogenesis. The aged C57BL/6 male mice with rotenone intragastric administration showed altered gut microbiota, which caused systemic inflammation, PPARγ signalling inhibition and neuroinflammation, brain iron deposition and ferroptosis, and eventually dopaminergic neurodegeneration in PD.PMID:37674043 | DOI:10.1038/s41401-023-01147-x
Source: Acta Pharmacologica Sinica - September 6, 2023 Category: Drugs & Pharmacology Authors: Xi-Zhen Ma Lei-Lei Chen Le Qu Hui Li Jun Wang Ning Song Jun-Xia Xie Source Type: research

Pages: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20