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Nutrition: Chloride
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Total 92 results found since Jan 2013.
Improvement in Lung Clearance Index and Chest CT Scores with Elexacaftor/Tezacaftor/Ivacaftor Treatment in People with Cystic Fibrosis Aged 12 Years and Older - The RECOVER Study
CONCLUSIONS: ETI is associated with substantial improvements in LCI2.5, spirometry and PRAGMA-CF CT scores in people with CF aged 12 years and older. ETI led to improved nutrition and quality of life. People in the F508del/F508del group have significantly lower sweat chloride on ETI treatment compared to the F508del/MF group. Clinical trial registration available at www.CLINICALTRIALS: gov, ID: NCT04602468.PMID:37703083 | DOI:10.1164/rccm.202308-1317OC
Source: Am J Respir Crit Car... - September 13, 2023 Category: Intensive Care Authors: Paul McNally Karen Lester Gavin Stone Basil Elnazir Michael Williamson Des Cox Barry Linnane Laura Kirwan David Rea Paul O'Regan Tom Semple Clare Saunders Harm A W M Tiddens Edward McKone Jane C Davies Source Type: research
Establishment and identification of an animal model of Hirschsprung disease in suckling mice
CONCLUSIONS: An economical and reliable HSCR animal model which has similar clinical characteristics to HSCR patients was successfully established.IMPACT: The animal model of Hirschsprung disease was first established in BALB/c mice. This model is an animal model of early-onset HSCR that is easy to operate and consistent with clinical manifestations. Transcriptome profiling of the mouse model and HSCR patients is similar in terms of altered gene expression.PMID:37460708 | DOI:10.1038/s41390-023-02728-6
Source: Pediatric Research - July 17, 2023 Category: Pediatrics Authors: Chaoting Lan Yuxin Wu Yanqing Liu Ning Wang Meiling Su Dingjiang Qin Weiyong Zhong Xinying Zhao Yun Zhu Qiuming He Huimin Xia Yan Zhang Source Type: research
Scaffold-free human vascular calcification model using a bio-three-dimensional printer
Biofabrication. 2023 Jun 20. doi: 10.1088/1758-5090/ace000. Online ahead of print.ABSTRACTMorbidity and mortality rates associated with atherosclerosis-related diseases are increasing. Therefore, developing new research models is important in furthering our understanding of atherosclerosis and investigate novel treatments. Here, we designed novel vascular-like tubular tissues from multicellular spheroids composed of human aortic smooth muscle cells (SMC), endothelial cells, and fibroblasts using a bio-3D printer. We also evaluated their potential as a research model for Mönckeberg's medial calcific sclerosis. The tubular ...
Source: Atherosclerosis - June 20, 2023 Category: Cardiology Authors: Yukiko Nagaishi Daiki Murata Hiromu Yoshizato Toshihiro Nonaka Manabu Itoh Hideo Hara Koichi Nakayama Source Type: research
Estimation of 24-hour urinary creatinine excretion from patient variables: A novel approach to identify patients with low muscle mass and malnutrition and relationship to outcomes
CONCLUSION: A model that predicts UCE offers a novel method to identify patients with low muscularity and malnutrition on admission without the use of invasive tests.PMID:37277930 | DOI:10.1002/ncp.11009
Source: Nutrition in Clinical Practice - June 6, 2023 Category: Nutrition Authors: Lynn Hiller Philip Foulis Susan Goldsmith James Epps Lauri Wright Source Type: research
Ataluren and similar compounds (specific therapies for premature termination codon class I mutations) for cystic fibrosis
CONCLUSIONS: There is currently insufficient evidence to determine the effect of ataluren as a therapy for people with CF with class I mutations. One trial reported favourable results for ataluren in a post hoc subgroup analysis of participants not receiving chronic inhaled aminoglycosides, but these were not reproduced in the later trial, suggesting that the earlier results may have occurred by chance. Future trials should carefully assess for adverse events, notably renal impairment, and consider the possibility of drug interactions. Cross-over trials should be avoided, given the potential for the treatment to change the...
Source: Cochrane Database of Systematic Reviews - March 3, 2023 Category: General Medicine Authors: Aisha A Aslam Ian P Sinha Kevin W Southern Source Type: research
Quantitative 3D Characterization for Kinetics of Corrosion Initiation and Propagation in Additively Manufactured Austenitic Stainless Steel
Adv Sci (Weinh). 2022 Oct 26:e2201162. doi: 10.1002/advs.202201162. Online ahead of print.ABSTRACTIn situ X-ray computed tomography (X-ray CT) is used to investigate the effects of characteristic microstructural features on the pitting initiation and propagation in austenitic stainless steel specimens prepared with laser powder bed fusion (LPBF) additive manufacturing. In situ X-ray CT in probing the mechanism and kinetics of localized corrosion is demonstrated by immersing two LPBF specimens with different porosities in an aggressive ferric chloride solution for the evaluation of corrosion. X-ray CT images are acquired fr...
Source: Adv Data - October 26, 2022 Category: Epidemiology Authors: Jianli Li Anthony E Hughes Y S Yang Majid Laleh Haipeng Wang Xufang Zhang Jie Ma Wei Xu Mike Y Tan Source Type: research
Arthroscopic reconstruction of scaphoid nonunions
Oper Orthop Traumatol. 2022 Apr 8. doi: 10.1007/s00064-022-00765-8. Online ahead of print.ABSTRACTOBJECTIVE: Minimally invasive arthroscopically assisted reconstruction of scaphoid nonunions.INDICATIONS: Delayed union or nonunion of the scaphoid with sclerosis and with indication for bone transplantation. Limited arthritic changes at the radial styloid.CONTRAINDICATIONS: Severe humpback deformity with dorsal intercalated segment instability. Midcarpal arthritic changes.SURGICAL TECHNIQUE: Supine position with the forearm upright and in neutral position, the elbow flexed by 90°, axial traction of 3 to 4 kg. Standard wrist ...
Source: Operative Orthopadie und Traumatologie - April 8, 2022 Category: Orthopaedics Authors: Steffen L öw Sebastian Kiesel Christian K Spies Holger Erne Source Type: research
