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Lactose-Functionalized Carbosilane Glycodendrimers Are Highly Potent Multivalent Ligands for Galectin-9 Binding: Increased Glycan Affinity to Galectins Correlates with Aggregation Behavior
Biomacromolecules. 2023 Sep 8. doi: 10.1021/acs.biomac.3c00426. Online ahead of print.ABSTRACTGalectins, the glycan binding proteins, and their respective carbohydrate ligands represent a unique fundamental regulatory network modulating a plethora of biological processes. The advances in galectin-targeted therapy must be based on a deep understanding of the mechanism of ligand-protein recognition. Carbosilane dendrimers, the well-defined and finely tunable nanoscaffolds with low toxicity, are promising for multivalent carbohydrate ligand presentation to target galectin receptors. The study discloses a synthetic method for ...
Source: Biomacromolecules - September 8, 2023 Category: Biochemistry Authors: Monika M üllerová Michaela Hovorkov á T áňa Závodná Lucie Červenková Št Astná Alena Krupkov á Vojt ěch Hamala Kate řina Nováková Jan Topinka Pavla Bojarov á Tom áš Strašák Source Type: research
Normolipidic diet containing deep-fried saturated and unsaturated fatty acids rich edible oils promotes metabolic dysregulation and inflammatory microenvironment in Wistar rats
This study investigated the influence of prolonged consumption of thermally oxidised long-chain saturated and unsaturated edible oils on metabolic dysregulation and inflammation. The thermally oxidised oils used in the study possess higher p-anisidine values and free fatty acid contents compared to unoxidised oils. Fourier transform infrared spectroscopy and fatty acid methyl ester analysis confirmed the presence of free fatty acids, hydroperoxides, and aldehydes, formed during thermal oxidation. The study analysed the effects of dietary intake of 5% sunflower oil, palm oil, and their thermally-oxidised forms in male Wista...
Source: Food and Chemical Toxicology - September 8, 2023 Category: Food Science Authors: Sruthi Panniyan Kandiyil Soorya Parathodi Illam Achuthan C Raghavamenon Source Type: research
Carbohydrates as putative pattern recognition receptor agonists in vaccine development
Trends Immunol. 2023 Sep 6:S1471-4906(23)00160-6. doi: 10.1016/j.it.2023.08.006. Online ahead of print.ABSTRACTAdjuvants are essential components of modern vaccines. One general mechanism underlying their immunostimulatory functions is the activation of pattern recognition receptors (PRRs) of innate immune cells. Carbohydrates - as essential signaling molecules on microbial surfaces - are potent PRR agonists and candidate materials for adjuvant design. Here, we summarize the latest trends in developing carbohydrate-containing adjuvants, with fresh opinions on how the physicochemical characteristics of the glycans (e.g., mo...
Source: Trends in Immunology - September 8, 2023 Category: Allergy & Immunology Authors: Ruoyu Mu Lei Dong Chunming Wang Source Type: research
Linker length-dependent morphologies in self-assembled structures of anthracene glucosides
Carbohydr Res. 2023 Aug 31;533:108933. doi: 10.1016/j.carres.2023.108933. Online ahead of print.ABSTRACTAnthracenemethyl glucosides, that possess ethylene glycol linkers connecting the glucoside with anthracene moiety, are studied herein. Koenigs-Knorr glycosylation of ethylene glycol-tethered anthracene with acetobromo glucose, followed by removal of the protecting groups, lead to the facile formation of the target glucosides. Aq. solutions of these anthracene glucosides readily undergo self-assembly, with critical aggregation concentration varying between 0.4 and 1 mM, depending on the linker, being ethylene-, di- and te...
Source: Carbohydrate Research - September 8, 2023 Category: Genetics & Stem Cells Authors: Anne George Narayanaswamy Jayaraman Source Type: research
Normolipidic diet containing deep-fried saturated and unsaturated fatty acids rich edible oils promotes metabolic dysregulation and inflammatory microenvironment in Wistar rats
This study investigated the influence of prolonged consumption of thermally oxidised long-chain saturated and unsaturated edible oils on metabolic dysregulation and inflammation. The thermally oxidised oils used in the study possess higher p-anisidine values and free fatty acid contents compared to unoxidised oils. Fourier transform infrared spectroscopy and fatty acid methyl ester analysis confirmed the presence of free fatty acids, hydroperoxides, and aldehydes, formed during thermal oxidation. The study analysed the effects of dietary intake of 5% sunflower oil, palm oil, and their thermally-oxidised forms in male Wista...
Source: Food and Chemical Toxicology - September 8, 2023 Category: Food Science Authors: Sruthi Panniyan Kandiyil Soorya Parathodi Illam Achuthan C Raghavamenon Source Type: research
N-methyl-O-benzylhydroxylamine derivatives of sialylated oligosaccharides, their synthesis and separation with reversed-phase HPLC
Carbohydr Res. 2023 Sep 3;533:108939. doi: 10.1016/j.carres.2023.108939. Online ahead of print.ABSTRACTThe human milk trisaccharide 3'- sialyllactose was reacted with an excess of N-methyl-O-benzylhydroxylamine (MBHA) and the product 3'- sialyllactose-MBHA was isolated in high (91%) yield by solid-phase extraction. The isomeric trisaccharide 6'-sialyllactose-MBHA was also prepared, in this case by enzymatic sialylation of lactose-MBHA. A 50/50 mixture of the two sialyllactose-MBHA derivatives was easily separated by reversed-phase HPLC. The free oligosaccharides were recovered from their respective MBHA derivatives by acid...
Source: Carbohydrate Research - September 8, 2023 Category: Genetics & Stem Cells Authors: Thomas Norberg Elisabet Kallin Source Type: research
Linker length-dependent morphologies in self-assembled structures of anthracene glucosides
Carbohydr Res. 2023 Aug 31;533:108933. doi: 10.1016/j.carres.2023.108933. Online ahead of print.ABSTRACTAnthracenemethyl glucosides, that possess ethylene glycol linkers connecting the glucoside with anthracene moiety, are studied herein. Koenigs-Knorr glycosylation of ethylene glycol-tethered anthracene with acetobromo glucose, followed by removal of the protecting groups, lead to the facile formation of the target glucosides. Aq. solutions of these anthracene glucosides readily undergo self-assembly, with critical aggregation concentration varying between 0.4 and 1 mM, depending on the linker, being ethylene-, di- and te...
Source: Carbohydrate Research - September 8, 2023 Category: Genetics & Stem Cells Authors: Anne George Narayanaswamy Jayaraman Source Type: research
Carbohydrate antigen 125 in atrial fibrillation
This article reviews the role of CA-125 in patients with atrial fibrillation.PMID:37683718 | DOI:10.1016/j.cca.2023.117550
Source: International Journal of Clinical Chemistry - September 8, 2023 Category: Chemistry Authors: Rangrang Zhang Weidong Jin Minglei Han Yonglan Hou Source Type: research
Antibacterial activity and mechanisms of α-terpineol against foodborne pathogenic bacteria
This study aimed to evaluate the antibacterial activities of α-terpineol against common foodborne pathogenic bacteria by agar well diffusion, broth microdilution, and colony counting assay. Propulsive research was conducted to reveal the antibacterial mechanisms, including morphology, infrared spectroscopy, membrane fluidity, membrane permeability, proton motive force, and oxidative phosphorylation. Results indicated that the antibacterial activity of α-terpineol decreased in the following order: Escherichia coli O157:H7, Salmonella typhimurium, Listeria monocytogenes, and Staphylococcus aureus. With an initial cell coun...
Source: Applied Microbiology and Biotechnology - September 8, 2023 Category: Microbiology Authors: Xiaoling Yang Shunan Zhao Yong Deng Weidong Xu Zonghan Wang Wenjun Wang Ruiling Lv Donghong Liu Source Type: research
Lactose-Functionalized Carbosilane Glycodendrimers Are Highly Potent Multivalent Ligands for Galectin-9 Binding: Increased Glycan Affinity to Galectins Correlates with Aggregation Behavior
Biomacromolecules. 2023 Sep 8. doi: 10.1021/acs.biomac.3c00426. Online ahead of print.ABSTRACTGalectins, the glycan binding proteins, and their respective carbohydrate ligands represent a unique fundamental regulatory network modulating a plethora of biological processes. The advances in galectin-targeted therapy must be based on a deep understanding of the mechanism of ligand-protein recognition. Carbosilane dendrimers, the well-defined and finely tunable nanoscaffolds with low toxicity, are promising for multivalent carbohydrate ligand presentation to target galectin receptors. The study discloses a synthetic method for ...
Source: Biomacromolecules - September 8, 2023 Category: Biochemistry Authors: Monika M üllerová Michaela Hovorkov á T áňa Závodná Lucie Červenková Št Astná Alena Krupkov á Vojt ěch Hamala Kate řina Nováková Jan Topinka Pavla Bojarov á Tom áš Strašák Source Type: research
Antibacterial activity and mechanisms of α-terpineol against foodborne pathogenic bacteria
This study aimed to evaluate the antibacterial activities of α-terpineol against common foodborne pathogenic bacteria by agar well diffusion, broth microdilution, and colony counting assay. Propulsive research was conducted to reveal the antibacterial mechanisms, including morphology, infrared spectroscopy, membrane fluidity, membrane permeability, proton motive force, and oxidative phosphorylation. Results indicated that the antibacterial activity of α-terpineol decreased in the following order: Escherichia coli O157:H7, Salmonella typhimurium, Listeria monocytogenes, and Staphylococcus aureus. With an initial cell coun...
Source: Applied Microbiology and Biotechnology - September 8, 2023 Category: Microbiology Authors: Xiaoling Yang Shunan Zhao Yong Deng Weidong Xu Zonghan Wang Wenjun Wang Ruiling Lv Donghong Liu Source Type: research
N-methyl-O-benzylhydroxylamine derivatives of sialylated oligosaccharides, their synthesis and separation with reversed-phase HPLC
Carbohydr Res. 2023 Sep 3;533:108939. doi: 10.1016/j.carres.2023.108939. Online ahead of print.ABSTRACTThe human milk trisaccharide 3'- sialyllactose was reacted with an excess of N-methyl-O-benzylhydroxylamine (MBHA) and the product 3'- sialyllactose-MBHA was isolated in high (91%) yield by solid-phase extraction. The isomeric trisaccharide 6'-sialyllactose-MBHA was also prepared, in this case by enzymatic sialylation of lactose-MBHA. A 50/50 mixture of the two sialyllactose-MBHA derivatives was easily separated by reversed-phase HPLC. The free oligosaccharides were recovered from their respective MBHA derivatives by acid...
Source: Carbohydrate Research - September 8, 2023 Category: Genetics & Stem Cells Authors: Thomas Norberg Elisabet Kallin Source Type: research
Linker length-dependent morphologies in self-assembled structures of anthracene glucosides
Carbohydr Res. 2023 Aug 31;533:108933. doi: 10.1016/j.carres.2023.108933. Online ahead of print.ABSTRACTAnthracenemethyl glucosides, that possess ethylene glycol linkers connecting the glucoside with anthracene moiety, are studied herein. Koenigs-Knorr glycosylation of ethylene glycol-tethered anthracene with acetobromo glucose, followed by removal of the protecting groups, lead to the facile formation of the target glucosides. Aq. solutions of these anthracene glucosides readily undergo self-assembly, with critical aggregation concentration varying between 0.4 and 1 mM, depending on the linker, being ethylene-, di- and te...
Source: Carbohydrate Research - September 8, 2023 Category: Genetics & Stem Cells Authors: Anne George Narayanaswamy Jayaraman Source Type: research
Carbohydrate antigen 125 in atrial fibrillation
This article reviews the role of CA-125 in patients with atrial fibrillation.PMID:37683718 | DOI:10.1016/j.cca.2023.117550
Source: International Journal of Clinical Chemistry - September 8, 2023 Category: Chemistry Authors: Rangrang Zhang Weidong Jin Minglei Han Yonglan Hou Source Type: research
