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Total 1377 results found since Jan 2013.
Combined Treatment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates
CONCLUSIONS: These results demonstrate the synergistic effect of combining iPSC-derived ECs and CMs for therapy in the postmyocardial infarction heart, enabling a promising strategy toward clinical translation.PMID:37732466 | DOI:10.1161/CIRCULATIONAHA.122.061736
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Yu-Che Cheng Marvin L Hsieh Chen-Ju Lin Cindy M C Chang Ching-Ying Huang Riley Puntney Amy Wu Moy Chien-Yu Ting Darien Zhing Herr Chan Martin W Nicholson Po-Ju Lin Hung-Chih Chen Gina C Kim Jianhua Zhang Jennifer Coonen Puja Basu Heather A Simmons Yen-Wen Source Type: research
Exosomes and their miRNA/protein profile in keratoconus-derived corneal stromal cells
Exp Eye Res. 2023 Sep 13:109642. doi: 10.1016/j.exer.2023.109642. Online ahead of print.ABSTRACTKeratoconus (KC) is a corneal thinning disorder and a leading cause of corneal transplantation worldwide. Exosomes are small, secreted extracellular vesicles (30-150 nm) that mediate cellular communication via their proteins, lipids, and nucleic acid content. We aimed to characterize the exosomes secreted by primary corneal fibroblasts from subjects with or without KC. Using human keratoconus stromal fibroblast cells (HKC, n = 4) and healthy stromal fibroblasts (HCF, n = 4), we collected and isolated exosomes using serial ultrac...
Source: Experimental Eye Research - September 15, 2023 Category: Opthalmology Authors: Rachel Hadvina Mariam Lotfy Khaled Theresa Akoto Wenbo Zhi Dimitrios Karamichos Yutao Liu Source Type: research
Human myofibroblasts increase the arrhythmogenic potential of human induced pluripotent stem cell-derived cardiomyocytes
Cell Mol Life Sci. 2023 Sep 5;80(9):276. doi: 10.1007/s00018-023-04924-3.ABSTRACTHuman induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have the potential to remuscularize infarcted hearts but their arrhythmogenicity remains an obstacle to safe transplantation. Myofibroblasts are the predominant cell-type in the infarcted myocardium but their impact on transplanted hiPSC-CMs remains poorly defined. Here, we investigate the effect of myofibroblasts on hiPSC-CMs electrophysiology and Ca2+ handling using optical mapping of advanced human cell coculture systems mimicking cell-cell interaction modalities. Human ...
Source: Cellular and Molecular Life Sciences : CMLS - September 5, 2023 Category: Cytology Authors: Robert D Johnson Ming Lei John H McVey Patrizia Camelliti Source Type: research
Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan.
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Trials of Xenotransplantation of Pig Organs into Humans Continue
https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/
Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants in...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Brain α2δ-1-Bound NMDA Receptors Drive Calcineurin Inhibitor-Induced Hypertension
CONCLUSIONS: These findings indicate that α2δ-1 is essential for calcineurin inhibitor-induced increases in synaptic NMDAR activity in PVN presympathetic neurons and sympathetic outflow. Thus, α2δ-1 and α2δ-1-bound NMDARs represent new targets for treating calcineurin inhibitor-induced hypertension.PMID:37605933 | DOI:10.1161/CIRCRESAHA.123.322562
Source: Circulation Research - August 22, 2023 Category: Cardiology Authors: Jing-Jing Zhou Jian-Ying Shao Shao-Rui Chen Hui-Lin Pan Source Type: research
