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Total 33 results found since Jan 2013.
Longitudinal interplay between subclinical atherosclerosis, cardiovascular risk factors, and cerebral glucose metabolism in midlife: results from the PESA prospective cohort study
Lancet Healthy Longev. 2023 Sep;4(9):e487-e498. doi: 10.1016/S2666-7568(23)00134-4.ABSTRACTBACKGROUND: Cardiovascular disease and dementia often coexist at advanced stages. Yet, longitudinal studies examining the interplay between atherosclerosis and its risk factors on brain health in midlife are scarce. We aimed to characterise the longitudinal associations between cerebral glucose metabolism, subclinical atherosclerosis, and cardiovascular risk factors in middle-aged asymptomatic individuals.METHODS: The Progression of Early Subclinical Atherosclerosis (PESA) study is a Spanish longitudinal observational cohort study of...
Source: Atherosclerosis - September 2, 2023 Category: Cardiology Authors: Catarina Trist ão-Pereira Valentin Fuster Belen Oliva Andrea Moreno-Arciniegas Ines Garcia-Lunar Cristina Perez-Herreras Michael Sch öll Marc Su árez-Calvet Maria Angeles Moro Ana Garcia-Alvarez Antonio Fernandez-Ortiz Javier Sanchez-Gonzalez Henrik Ze Source Type: research
Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome
J Clin Endocrinol Metab. 2023 Aug 15:dgad463. doi: 10.1210/clinem/dgad463. Online ahead of print.ABSTRACTSTUDY QUESTION: What is the recommended assessment and management of those with polycystic ovary syndrome (PCOS), based on the best available evidence, clinical expertise, and consumer preference?SUMMARY ANSWER: International evidence-based guidelines address prioritized questions and outcomes and include 254 recommendations and practice points, to promote consistent, evidence-based care and improve the experience and health outcomes in PCOS.WHAT IS KNOWN ALREADY: The 2018 International PCOS Guideline was independently ...
Source: The Journal of Clinical Endocrinology and Metabolism - August 14, 2023 Category: Endocrinology Authors: Helena J Teede Chau Thien Tay Joop J E Laven Anuja Dokras Lisa J Moran Terhi T Piltonen Michael F Costello Jacky Boivin Leanne M Redman Jacqueline A Boyle Robert J Norman Aya Mousa Anju E Joham International PCOS Network Source Type: research
STNM01, the RNA oligonucleotide targeting carbohydrate sulfotransferase 15, as second-line therapy for chemotherapy-refractory patients with unresectable pancreatic cancer: An open label, phase I/IIa trial
EClinicalMedicine. 2022 Nov 17;55:101731. doi: 10.1016/j.eclinm.2022.101731. eCollection 2023 Jan.ABSTRACTBACKGROUND: The impact of stroma-targeting therapy on tumor immune suppression is largely unexplored. An RNA oligonucleotide, STNM01, has been shown to repress carbohydrate sulfotransferase 15 (CHST15) responsible for tumor proteoglycan synthesis and matrix remodeling. This phase I/IIa study aimed to evaluate the safety and efficacy of STNM01 in patients with unresectable pancreatic ductal adenocarcinoma (PDAC).METHODS: This was an open-label, dose-escalation study of STNM01 as second-line therapy in gemcitabine plus n...
Source: Cancer Control - November 25, 2022 Category: Cancer & Oncology Authors: Toshio Fujisawa Takayoshi Tsuchiya Motohiko Kato Masafumi Mizuide Kazuki Takakura Makoto Nishimura Hiromu Kutsumi Yoko Matsuda Tomio Arai Shomei Ryozawa Takao Itoi Hiroyuki Isayama Hideyuki Saya Naohisa Yahagi Source Type: research
Transbronchial needle aspiration combined with cryobiopsy in the diagnosis of mediastinal diseases: a multicentre, open-label, randomised trial
Lancet Respir Med. 2022 Oct 21:S2213-2600(22)00392-7. doi: 10.1016/S2213-2600(22)00392-7. Online ahead of print.ABSTRACTBACKGROUND: Transbronchial mediastinal cryobiopsy is a novel sampling technique for mediastinal disease. Despite the possibility of lung cancer misdiagnosis, the improved diagnostic yield of this approach for non-lung-cancer lesions compared with standard endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) highlights its diagnostic potential as a complementary technique to conventional biopsy. We aimed to evaluate the safety profile and added value of the combined use of transbron...
Source: Respiratory Care - October 24, 2022 Category: Respiratory Medicine Authors: Ye Fan An-Mei Zhang Xian-Li Wu Zan-Sheng Huang Konstantina Kontogianni Kai Sun Wan-Lei Fu Na Wu Wolfgang M Kuebler Felix J F Herth Source Type: research
Snapshot of ultrasound imaging in basic anatomy and physiology teaching in the United Kingdom and Republic of Ireland: perceptions, obstacles and solutions
Adv Physiol Educ. 2022 Sep 8. doi: 10.1152/advan.00193.2022. Online ahead of print.ABSTRACTWe have used ultrasound imaging and technology as a tool for non-clinical teaching of basic physiological concepts for several years and are aware anecdotally that only a few others in the UK and Republic of Ireland (ROI) are also using ultrasound with this intention in physiology and anatomy teaching. To better understand what areas ultrasound is used for by others, along with what barriers might exist to its use, we reached out to colleagues in UK/ROI institutions instructing on anatomy and physiology courses by asking them to comp...
Source: Adv Physiol Educ - September 8, 2022 Category: Universities & Medical Training Authors: Emma C Graham Eva M Sweeney Christopher D Johnson Source Type: research
