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Total 40 results found since Jan 2013.
Her work paved the way for blockbuster obesity drugs. Now, she ’s fighting for recognition
When Svetlana Mojsov heard the spring 2021 announcement, she was startled. The Canada Gairdner International Award, a prestigious biomedical research prize, would be bestowed on three scientists for work underpinning the diabetes and obesity drugs that have exploded in popularity in recent years. “I was really upset,” recalls Mojsov, a chemist at Rockefeller University.
The Gairdner award marked the third time in 4 years that the same trio of scientists—Joel Habener at Massachusetts General Hospital (MGH), Daniel Drucker at the University of Toronto, and Jens Juul Holst at the University of Copenhagen—were hon...
Source: Science of Aging Knowledge Environment - September 8, 2023 Category: Geriatrics Source Type: research
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 24th 2023
In this study, researchers show that mice lacking a functional ATF4 gene show little to no loss of grip strength and treadmill performance into late life; it is quite an impressive effect size. Assessments of muscle biochemistry do show age-related declines, but to a lesser degree than the controls. How ATF4 knockout functions to produce this outcome is an interesting question. The researchers point out a range of possible downstream and upstream targets that have been implicated in the regulation of muscle growth, but it will clearly require further work to identify the important mechanisms involved.
Aging slowly...
Source: Fight Aging! - April 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
On the value of diverse organisms in auditory research: From fish to flies to humans
Hear Res. 2023 Mar 30;432:108754. doi: 10.1016/j.heares.2023.108754. Online ahead of print.ABSTRACTHistorically, diverse organisms have contributed to our understanding of auditory function. In recent years, the laboratory mouse has become the prevailing non-human model in auditory research, particularly for biomedical studies. There are many questions in auditory research for which the mouse is the most appropriate (or the only) model system available. But mice cannot provide answers for all auditory problems of basic and applied importance, nor can any single model system provide a synthetic understanding of the diverse ...
Source: Hearing Research - April 13, 2023 Category: Audiology Authors: Andrew D Brown Tamasen Hayward Christine V Portfors Allison B Coffin Source Type: research
Make a Perfect Pair with NIH Matchmaker
While we may not be able to help you look for love, we do have a tool that can help you find the perfect match at NIH for your research.
There’s plenty of fish in the sea, as NIH is made up of 27 institutes and centers (often referred to as ICs), 24 of which can make grant awards. and have distinct missions that focus on a specific disease area, organ system, or stage of life.
Our Matchmaker tool in RePORTER can help you determine which IC may be interested in your idea, which NIH program official you might want to reach out to, and which study section you might want to suggest your application gets a...
Source: NIH Extramural Nexus - February 13, 2023 Category: Research Authors: NIH Staff Tags: Tips Before You Submit Funding data Matchmaker RePORTER Source Type: funding
News at a glance: LGBTQ+ Nobel laureates, a statistics prize, and the return of the snail darter
CONSERVATION
Once-controversial fish delisted
A small fish famous for drawing the first U.S. Supreme Court ruling on the Endangered Species Act was removed last week by the U.S. Fish and Wildlife Service from the list of species under threat of extinction. In 1975, the agency declared the snail darter (
Percina tanasi
) endangered, concluding that construction of a dam on the Little Tennessee River would doom the 9-centimeter-long animals. Although the court upheld the listing in 1978, Congress allowed the dam to go ahead. The darter’s outlook improved after some were moved to other streams, more po...
Source: ScienceNOW - October 13, 2022 Category: Science Source Type: news
Evidence suggests pandemic came from nature, not a lab, panel says
The acrimonious debate over the origins of the COVID-19 pandemic flared up again this week with a report from an expert panel concluding that SARS-CoV-2 likely spread naturally in a zoonotic jump from an animal to humans—without help from a lab.
“Our paper recognizes that there are different possible origins, but the evidence towards zoonosis is overwhelming,” says co-author Danielle Anderson, a virologist at the University of Melbourne. The report, which includes an analysis that found the peer-reviewed literature overwhelmingly supports the zoonotic hypotheses,
appeared in the
Proceedings of the Nationa...
Source: ScienceNOW - October 10, 2022 Category: Science Source Type: news
News at a glance: Webb telescope dinged, U.S.-Russia research paused, and NASA ’s UFO study
Table of contents
A version of this story appeared in Science, Vol 376, Issue 6599.
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ASTRONOMY
Star mapper provides Milky Way portrait
he European Space Agency’s Gaia satellite has now mapped almost 2 billion of the Milky Way’s stars, logging their positions, speeds, temperatures, and other parameters—and allowing astronomers to chart the Galaxy’s structure and evolution. Last week, operators released the third major trove of data, including lists of 800,000 binary stars, 10 million variable stars, and, within the Solar System, 156,000...
Source: Science of Aging Knowledge Environment - June 16, 2022 Category: Geriatrics Source Type: research
Fight Aging! Newsletter, November 22nd 2021
This study nicely illustrates the importance of the cellular metabolic state of myeloid cells: it highlights that not only the availability of glucose, but also its channeling into different pathways (glycolysis versus glycogen synthesis) contributes to maintaining proper myeloid function.
On the Ability of Redundant Blood Vessels to Lower Cardiovascular Mortality
https://www.fightaging.org/archives/2021/11/on-the-ability-of-redundant-blood-vessels-to-lower-cardiovascular-mortality/
A few strategies offer the possibility of growing additional redundant blood vessels, though this is far from rigorously pr...
Source: Fight Aging! - November 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mercury (Hg) use and pollution assessment of ASGM in Ghana: challenges and strategies towards Hg reduction
This article provides a recent overview of ASGM gold production and Hg use in Ghana. In addition, in order to highlight the impacts of Hg use in Ghana, a review was conducted on research studies investigating Hg pollution in waterbodies, soils, fish, and humans caused by ASGM over the past two decades. The continued use of Hg in Ghana's growing ASGM sector has resulted in reportedly high Hg levels found in water, sediments, crops, and miners, which exceed international guidelines. A subsequent ASGM ban and increased monitoring of illegal mining activities in Ghana have not ultimately been successful at significantly reduci...
Source: Environmental Science and Pollution Research International - September 22, 2021 Category: Environmental Health Authors: Alex Kwasi Saim Source Type: research
Improving species status assessments under the U.S. endangered species act and implications for multispecies conservation challenges worldwide
This article is protected by copyright. All rights reserved.PMID:34057264 | DOI:10.1111/cobi.13777
Source: Conservation Biology - May 31, 2021 Category: Biology Authors: Reed F Noss Jennifer M Cartwright Dwayne Estes Theo Witsell Gregg Elliott Daniel Adams Matthew Albrecht Ryan Boyles Patrick Comer Chris Doffitt JoVonn Hill William C Hunter Wesley M Knapp Michael E Marshall Jason Singhurst Christopher Tracey Jeffrey Walck Source Type: research
Fight Aging! Newsletter, May 10th 2021
This study suggests that some of those changes contribute to age-related hypertension, providing yet another reason to put resources into the near term development of therapies that can reverse the aging of the gut microbiome, such as flagellin vaccination or fecal microbiota transplantation.
"Previous studies from our lab have shown that the composition of the gut microbiota in animal models of hypertension, such as the SHRSP (spontaneously hypertensive stroke-prone) rat model, is different from that in animals with normal blood pressure. Further, transplanting dysbiotic gut microbiota from a hypertensive animal ...
Source: Fight Aging! - May 9, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
