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Screening, Brief Intervention and Referral to Treatment or Prevention (SBIRT/P) for alcohol, tobacco, and other drugs (ATOD) use and misuse in adult populations that experience health disparities (R01, Clinical Trial Required)
Funding Opportunity PAR-23-270 from the NIH Guide for Grants and Contracts. The Office of Disease Prevention (ODP) and participating National Institutes of Health (NIH) Institutes, Centers, and Offices (ICOs) are issuing this notice of funding opportunity (NOFO) seeking applications to test innovative approaches to implementing SBIRT/P for alcohol, tobacco, and other drugs (ATOD) use and misuse in adult populations that experience health disparities. SBIRT/P, (a term used for purposes of this funding announcement), involves screening individuals for risk of ATOD use and misuse, briefly intervening with a conversation abou...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 16, 2023 Category: Research Source Type: funding

Folate deficiency increases the incidence of dolutegravir-associated foetal defects in a mouse pregnancy model
EBioMedicine. 2023 Aug 14;95:104762. doi: 10.1016/j.ebiom.2023.104762. Online ahead of print.ABSTRACTBACKGROUND: Dolutegravir (DTG) is a recommended first-line regimen for all people with Human Immunodeficiency Virus (HIV) infection. Initial findings from Botswana, a country with no folate fortification program, showed an elevated prevalence of neural tube defects (NTDs) with peri-conceptional exposure to DTG. Here we explore whether a low folate diet influences the risk of DTG-associated foetal anomalies in a mouse model.METHODS: C57BL/6 mice fed a folate-deficient diet for 2 weeks, were mated and then randomly allocated ...
Source: Cancer Control - August 16, 2023 Category: Cancer & Oncology Authors: Haneesha Mohan Jessica Nguyen Ben MacKenzie Audrey Yee Evelyn Yukino Laurette Tanvi Sanghvi Oscar Tejada Valeriya Dontsova Kit-Yi Leung Cameron Goddard Taylor De Young John G Sled Nicholas D E Greene Andrew J Copp Lena Serghides Source Type: research

Federal Government Announces Long COVID Trials, Research Office
The launch of a suite of clinical trials investigating treatments for post –COVID-19 condition and the formation of the Office of Long COVID Research and Practice are the federal government’s latest actions to understand and improve the lives of patients living with long COVID, the US Department for Health and Human Services (HHS) and National Institutes of Health (NIH ) said in recent announcements.
Source: JAMA - Journal of the American Medical Association - August 16, 2023 Category: General Medicine Source Type: research

Your cells don ’t have the genome you were born with. Project aims to chart impact of new mutations
Every person starts with just one genome, the unique amalgam of paternal and maternal DNA in the fertilized egg. And researchers long thought that over a lifetime, pretty much all of the body’s diverse cells inherit that same genome. But large-scale DNA sequencing over the past decade or so has toppled that view, showing that human DNA starts to accrue mutations early in embryonic development and continues to change throughout life. “The genome you are conceived with is very different from the genome you die with,” says cardiovascular biologist Kenneth Walsh of the University of Virginia. As a result, every pers...
Source: Science of Aging Knowledge Environment - August 15, 2023 Category: Geriatrics Source Type: research

NIAMS Coalition Outreach and Education Meeting - September 2023
The biennial NIAMS Coalition Outreach and Education Meeting provides a forum for our Coalition members to share best practices with each other on the importance of connecting science to the public, while gaining a better understanding of how the National Institutes of Health (NIH) and the NIAMS function. The day-long event is designed to share the latest research advances and related developments, and to foster dialogue on the future path and directions of NIAMS-funded research. The target audience for this event is the NIAMS Coalition, an independent consortium of about 100 professional and voluntary organizations that ra...
Source: Videocast - All Events - August 15, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video

NIH unveils comprehensive proteogenomic dataset to help cancer researchers unravel molecular mysteries
Researchers from around the world will be able to use this publicly available resource.
Source: National Institutes of Health (NIH) News Releases - August 14, 2023 Category: American Health Source Type: news

Cerebellar post-stroke deep brain stimulation appears safe and feasible in a small trial
Early NIH-funded trial is first step towards development of a potential stroke treatment.
Source: National Institutes of Health (NIH) News Releases - August 14, 2023 Category: American Health Source Type: news

Air pollution from different emission sources is associated with incident dementia
NIH-funded study suggests reducing exposure to airborne particulates may decrease dementia risk.
Source: National Institutes of Health (NIH) News Releases - August 14, 2023 Category: American Health Source Type: news

A Science of Science Approach to Analyzing and Innovating the Biomedical Research Enterprise (SoS:BIO)
Full Proposal Target Date: September 11, 2023 Program Guidelines: NSF 23-569The National Science Foundation (NSF) and the National Institutes of Health (NIH) are interested in proposals that will propel our understanding of the biomedical research enterprise by drawing from the scientific expertise of the science of science policy research community. NSF promotes the progress of science by maintaining the general health of research and education across all fields of science and engineering. The Social, Behavioral and Economic Sciences (SBE) Directorate ...More at https://beta.nsf.gov/programid/505610This is an NSF Upcoming Due Dates item.
Source: NSF Upcoming Due Dates - August 12, 2023 Category: Science Source Type: funding

COVID-19 vaccination and boosting during pregnancy benefits pregnant people and newborns
Clinical trial sought to determine to how much protection against illness the vaccines provided
Source: National Institutes of Health (NIH) News Releases - August 10, 2023 Category: American Health Source Type: news

NIH withdraws opposition to unionization effort
After questioning the legal standing of a unionization effort by early-career researchers, the U.S. National Institutes of Health (NIH) now says it won’t oppose a vote by potential union members. “I am excited the NIH has chosen to do the right thing,” says Marjorie Levinstein, a neuropharmacology postdoc at the National Institute on Drug Abuse and an organizer for the proposed union, called NIH Fellows United. In June, Levinstein and other organizers filed paperwork with the Federal Labor Relations Authority requesting to hold an election to determine whether the majority of the 4800 nonpermanent researchers wh...
Source: ScienceNOW - August 10, 2023 Category: Science Source Type: news

News at a glance: A win for obesity drugs, NIH unionization roadblocks, and Mexican fireflies under threat
CONSERVATION Researchers raise alarm over threat to Mexican fireflies Scientists from the International Union for Conservation of Nature (IUCN) last week delivered a letter to the Mexican government requesting it regulate tourism centered on the threatened firefly species Photinus palaciosi . Endemic to Mexico’s Tlaxcala forests, P. palaciosi is one of the few species that glow in synchrony, offering an annual spectacle that attracts thousands of visitors during summer mating season. The letter describes how littering, artificial light, and noise interfere with the insects’ courtship and eg...
Source: ScienceNOW - August 10, 2023 Category: Science Source Type: news

NIH zebrafish research included in U.S. Postal Service ’s “Life Magnified” stamps
The work led to a groundbreaking discovery that zebrafish have lymphatic vessels inside their skull.
Source: National Institutes of Health (NIH) News Releases - August 10, 2023 Category: American Health Source Type: news

Hearing aids slow cognitive decline in people at high risk
Hearing aids cut the rate of cognitive decline by nearly half in older adults at high risk of dementia.
Source: NIH Research Matters from the National Institutes of Health (NIH) - August 8, 2023 Category: Consumer Health News Source Type: news

Cell atlases give detailed views of human organs
Detailed cellular maps reveal the spatial organization of cells within the human kidney, intestine, and placenta.
Source: NIH Research Matters from the National Institutes of Health (NIH) - August 8, 2023 Category: Consumer Health News Source Type: news