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Total 11251 results found since Jan 2013.

Petabyte-Scale Sequence Search: Metagenomics Benchmarking Codeathon Highlights
The National Institutes of Health (NIH) Office of Data Science Strategy (ODSS), the National Library of Medicine’s (NLM’s) National Center for Biotechnology and Information (NCBI), and the Department of Energy’s (DOE’s) Office of Biological and Environmental Research (BER) hosted scientists from around the world for a virtual Petabyte-Scale Sequence Search: Metagenomics Benchmarking Codeathon. The codeathon, … Continue reading Petabyte-Scale Sequence Search: Metagenomics Benchmarking Codeathon Highlights →
Source: NCBI Insights - December 17, 2021 Category: Databases & Libraries Authors: NCBI Staff Tags: What's New Basic Local Alignment Search Tool (BLAST) Codeathon Sequence Read Archive (SRA) Source Type: news

A Novel and Efficient Technology for Targeted Delivery of siRNA
The biological phenomenon of RNA interference (RNAi) has much promise for developing therapeutics to a variety of diseases. However, development of RNAi therapies remains mainly in preclinical stages largely because of difficulties in delivering small inhibitory RNAs (siRNA) and short hairpin RNAs (shRNA) into target cells. Although viral vector-based siRNA delivery systems have been widely used, their specificity and safety remains significant issue. Without a solution to this delivery problem, RNAi cannot fulfill its therapeutic promise. Investigators at the National Institutes of Health have developed novel compositions...
Source: NIH OTT Licensing Opportunities - January 1, 2009 Category: Research Authors: admin Source Type: research

Next Phase of NIH Preprint Pilot Launching Soon
Last month, the National Library of Medicine (NLM)announced plans to extend its NIH Preprint Pilot in PubMed Central (PMC) and PubMed beyond COVID-19 to encompass all preprints reporting on NIH-funded research. The second phase of the pilot, launching later this month, will include preprints supported by an NIH award, contract, or intramural program and posted to aneligible preprint server on or after January 1, 2023.In preparation for the launch of this second phase, we have updated PMC and PubMed site features to help users of these databases incorporate the increased volume of preprints into their discovery workflows. S...
Source: PubMed Central News - January 10, 2023 Category: Databases & Libraries Source Type: news

Second Phase of the NIH Preprint Pilot Launched
Today, we are pleased to announce the launch of the second phase of the NIH Preprint Pilot with the addition of more than 700 new preprint records to PubMed Central (PMC) and PubMed. This second phase expands the scope of the Pilot to include preprints resulting from all NIH-funded research. Eligible preprints are those acknowledging direct support of an NIH award or authored by NIH staff and posted to bioRxiv, medRxiv, arXiv, or Research Square, on or after January 1, 2023. NLM will automatically include the full text of the preprint (as license terms allow) and associated citation information in PMC and PubMed, respectiv...
Source: PubMed Central News - January 30, 2023 Category: Databases & Libraries Source Type: news

Targeted Delivery of siRNA
The biological phenomenon of RNA interference (RNAi) has much promise for developing therapeutics to a variety of diseases. However, development of RNAi therapies remains mainly in preclinical stages largely because of difficulties in delivering small inhibitory RNAs (siRNA) and short hairpin RNAs (shRNA) into target cells. Although viral vector-based siRNA delivery systems have been widely used, their specificity and safety remain significant issues. Without a solution to these delivery problems, RNAi cannot fulfill its therapeutic promise.Scientists at the National Institutes of Health, National Institute on Aging have d...
Source: NIH OTT Licensing Opportunities - January 1, 2009 Category: Research Authors: ajoyprabhu3 Source Type: research

Evolution of a Search: The Use of Dynamic Twitter Searches During Superstorm Sandy
PLOS: Currents: Disasters, September 26, 2014 This research article, co-authored by National Institutes of Health librarian Alicia Livinski, is an example of collaboration between a library and public health agency developing search strategies to organize and monitor the vast array of information sent out via Twitter during a disaster. http://currents.plos.org/disasters/article/evolution-of-a-search-the-use-of-dynamic-twitter-searches-during-superstorm-sandy/
Source: NN/LM Middle Atlantic Region Blog - October 19, 2014 Category: Databases & Libraries Authors: mjharvey Tags: Disaster / Emergency Preparedness Education News from NLM/NIH Outreach Public Health Technology Technology and Libraries Source Type: news

The search is on for a hepatitis B drug, thanks to a million dollars in NIH grants to SLU
(Saint Louis University) Two grants from the National Institutes of Health will allow Saint Louis University researchers to build on breakthroughs in understanding the hepatitis B virus and begin the search for a drug to cure -- not just halt -- the illness.
Source: EurekAlert! - Medicine and Health - March 25, 2014 Category: Global & Universal Source Type: news

The impact of stroke on bone properties and muscle-bone relationship: a systematic review and meta-analysis
AbstractTo systematically review available evidence related to the characteristics of bone changes post-stroke and the relationship between various aspects of muscle function (e.g., strength, spasticity) and bone properties after stroke onset. An extensive online database search was undertaken (last search in January 2019). Articles that examined the bone properties in stroke patients were included. The quality of the studies was evaluated with the National Institutes of Health (NIH) Study Quality Assessment Tools. Publication bias of meta-analyses was assessed using the Egger ’s regression asymmetry test. The selection ...
Source: Osteoporosis International - November 12, 2019 Category: Orthopaedics Source Type: research

New NIEHS director — the search is on
<div class="rxbodyfield">The National Institutes of Health opens a nationwide search for the next director of NIEHS and the National Toxicology Program. Apply by Dec. 23.</div> (read more)
Source: Environmental Factor - NIEHS Newsletter - December 2, 2019 Category: Environmental Health Source Type: news

Tackling Petabyte Scale Sequence Search Challenges
The volume of biological data being generated by the scientific community is growing exponentially, reflecting technological advances and research activities. This increase in available data has great promise for pushing scientific discovery but also introduces new challenges that scientific communities need to address. The National Institutes of Health’s (NIH) Sequence Read Archive (SRA), which is … Continue reading Tackling Petabyte Scale Sequence Search Challenges →
Source: NCBI Insights - August 9, 2021 Category: Databases & Libraries Authors: NCBI Staff Tags: What's New Sequence Read Archive (SRA) STRIDES Source Type: news

New NIEHS director — the search is on
<img width="100" src="https://factor.niehs.nih.gov/sites/niehs-factor/files/styles/large/public/2019/12/feature/3-feature-director/thumb881462.jpg?itok=hyMTYjdC" /><br /><p>The National Institutes of Health opens a nationwide search for the next director of NIEHS and the National Toxicology Program. Apply by Dec. 23.</p> (read more)
Source: Environmental Factor - NIEHS Newsletter - February 3, 2023 Category: Environmental Health Source Type: news

Scientists use AI to identify likely drug targets in search for Alzheimer ' s cure
Scientists use AI to identify likely drug targets in search for Alzheimer's cure A team led by a University of Arizona College of Medicine – Tucson scientist harnesses artificial intelligence to trace the path from a healthy brain cell to one afflicted by Alzheimer ' s disease. Anna C. Christensen Today College of Medicine – TucsonRui-Chang_khp-web.jpg Rui Chang, an associate professor of neurology, is leading a team at the College of Medicine – Tucson that uses artificial intelligence to trace the molecular path of the development of Alzheimer's disease.HealthCollege of Medicine - TucsonDeterminationE...
Source: The University of Arizona: Health - May 15, 2023 Category: Universities & Medical Training Authors: mittank Source Type: research

NLM ’s LitVar 2.0 Provides More Accurate & Comprehensive Way to Search for Genetic Variants in Biomedical Literature
A team of researchers from the National Library of Medicine (NLM) at the National Institutes of Health (NIH) and the Broad Institute developed an improved web-based system, LitVar 2.0, to help researchers and clinicians search for genetic variants and related information in the biomedical literature. A paper about this powerful LitVar 2.0 system was published in Nature Genetics.
Source: NLM General Announcements - June 7, 2023 Category: Databases & Libraries Source Type: news

High-Throughput Characterization of Viral and Cellular Protein Expression Patterns During JC Polyomavirus Infection
Discussion The study of viral infections in vitro has provided innumerable advances to the field of virology. However, the lack of rapid and efficient screening tools has hindered research progress for some viruses, like JCPyV (Houff et al., 1983; Zu Rhein, 1983; Assetta and Atwood, 2017). To overcome this challenge, the development of high-throughput analyses is needed to help aid in the production of large data sets and generation of multiple lines of inquiry. Current methodologies for analyzing JCPyV infectivity predominantly rely on manual quantitation of infection by indirect immunodetection of viral proteins by epif...
Source: Frontiers in Microbiology - April 16, 2019 Category: Microbiology Source Type: research

Autophagy Is a Defense Mechanism Inhibiting Invasion and Inflammation During High-Virulent Haemophilus parasuis Infection in PK-15 Cells
In this study, we sought to investigate whether SH0165 (serovar 5, high-virulent strain) and HN0001 (serovar 6, non-virulent strain) infection induces autophagy and the specific role of autophagy in bacterial invasion and inflammation during H. parasuis infection. Moreover, we explored the mechanism underlying autophagy regulated inflammation through inflammatory signaling cascades during H. parasuis infection. This observation could provide useful information for further understanding the role of autophagy in H. parasuis infection and improve our knowledge of new strategies against this pathogen. Materials and Methods B...
Source: Frontiers in cellular and infection microbiology - April 15, 2019 Category: Microbiology Source Type: research