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Total 42 results found since Jan 2013.
Is low-risk status a surrogate outcome in pulmonary arterial hypertension? An analysis of three randomised trials
Lancet Respir Med. 2023 May 22:S2213-2600(23)00155-8. doi: 10.1016/S2213-2600(23)00155-8. Online ahead of print.ABSTRACTBACKGROUND: Targeting short-term improvements in multicomponent risk scores for mortality in patients with pulmonary arterial hypertension (PAH) could result in improved long-term outcomes. We aimed to determine whether PAH risk scores were adequate surrogates for clinical worsening or mortality outcomes in PAH randomised clinical trials (RCTs).METHODS: We performed an individual participant data meta-analysis of RCTs selected from PAH trials provided by the US Food and Drug Administration (FDA). We calcu...
Source: Respiratory Care - May 25, 2023 Category: Respiratory Medicine Authors: Bryan S Blette Jude Moutchia Nadine Al-Naamani Corey E Ventetuolo Chao Cheng Dina Appleby Ryan J Urbanowicz Jason Fritz Jeremy A Mazurek Fan Li Steven M Kawut Michael O Harhay Source Type: research
Lung Imaging of COPD: Part 2: Emerging Concepts Lung Imaging in COPD: Part 2: Emerging Concepts
This article discusses important emerging techniques in imaging patients with COPD. The clinical utility of these emerging techniques as they stand today are tabulated for the benefit of the practicing pulmonologist., Abbreviation: BLVR - bronchoscopic lung volume reduction, LVRS - lung volume reduction surgery., LAAs - low attenuating areas., PD15 - lowest 15th percentile of lung histogram, FDA - Food and Drug Administration, Author Conflicts of Interest.PMID:36907375 | DOI:10.1016/j.chest.2023.02.049
Source: Chest - March 12, 2023 Category: Respiratory Medicine Authors: Suhail Raoof Manav Shah Sidney Braman Abhinav Agrawal Hassan Allaqaband Russell Bowler Peter Castaldi Dawn DeMeo Shannon Fernando Charles Scott Hall Meilan Han James Hogg Stephen Humphries Ho Yun Lee Kyung Soo Lee David Lynch Stephen Machnicki Atul Mehta Source Type: research
Food Color Additives in Hazardous Consequences of Human Health: An Overview
Curr Top Med Chem. 2023 Jan 17. doi: 10.2174/1568026623666230117122433. Online ahead of print.ABSTRACTFood color additives are used to make food more appetizing. The United States Food and Drug Administration (FDA) permitted nine artificial colorings in foods, drugs, and cosmetics, whereas the European Union (EU) approved five artificial colors (E-104, 122, 124, 131, and 142) for food. However, these synthetic coloring materials raise various health hazards. The present review aimed to summarize the toxic effects of these coloring food additives on the brain, liver, kidney, lungs, urinary bladder, and thyroid gland. In thi...
Source: Current Topics in Medicinal Chemistry - January 18, 2023 Category: Chemistry Authors: Sharifa Sultana Md Mominur Rahman Farjana Islam Aovi Farhana Ishrat Jahan Md Sakhawat Hossain Shadia Afrin Brishti Md Yamin Muniruddin Ahmed Abdur Rauf Rohit Sharma Source Type: research
Pragmatic randomised controlled trials in COPD and asthma: how to guide clinical practice
Discussions in recent scientific workshops explored the importance of pragmatic RCTs in optimising guideline development and patient care in chronic obstructive pulmonary disease (COPD) and asthma. The Salford Lung Study in patients with COPD (NCT01551758) and asthma (NCT01706198) were the world's first prelicence pragmatic RCTs that compared novel investigational treatments with existing COPD and asthma treatments and, more recently (2021), RWE studies have been used by the American Thoracic Society and the US Food and Drug Administration to support the approval of an immunosuppressant drug in patients receiving lung tran...
Source: Respiratory Care - September 30, 2022 Category: Respiratory Medicine Authors: Nawar Diar Bakerly Kirill Nikitin Neil G Snowise Glenn Cardwell Daryl Freeman Ravijyot Saggu Anthony De Soyza Source Type: research
Fight Aging! Newsletter, February 7th 2022
In this study, we used accelerometer measurements (1) to examine the association of physical activity and mortality in a population-based sample of US adults and (2) to estimate the number of deaths prevented annually with modest increases in moderate-to-vigorous physical activity (MVPA) intensity.
This analysis included 4,840 participants. Increasing MVPA by 10, 20, or 30 minutes per day was associated with a 6.9%, 13.0%, and 16.9% decrease in the number of deaths per year, respectively. We estimated that approximately 110,000 deaths per year could be prevented if US adults aged 40 to 85 years or older increased th...
Source: Fight Aging! - February 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
High-content Screen Identifies Cyclosporin A as a Novel ABCA3-specific Molecular Corrector
Am J Respir Cell Mol Biol. 2021 Dec 22. doi: 10.1165/rcmb.2021-0223OC. Online ahead of print.ABSTRACTATP-binding cassette (ABC) subfamily A member 3 (ABCA3) is a lipid transporter expressed in alveolar type II cells and localized in the limiting membrane of lamellar bodies. It is crucial for pulmonary surfactant storage and homeostasis. Mutations in the ABCA3 gene are the most common genetic cause of respiratory distress syndrome in mature newborns and interstitial lung disease in children. Apart from lung transplantation, there is no cure available. To address the lack of causal therapeutic options for ABCA3 deficiency, a...
Source: American Journal of Respiratory Cell and Molecular Biology - December 22, 2021 Category: Molecular Biology Authors: Maria Forstner Sean Lin Xiaohua Yang Susanna Kinting Ina Rothenaigner Kenji Schorpp Yang Li Kamyar Hadian Matthias Griese Source Type: research
