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Nutrition: Sodium
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Total 749 results found since Jan 2013.
Safety and efficacy of the epithelial sodium channel blocker idrevloride in people with primary ciliary dyskinesia (CLEAN-PCD): a multinational, phase 2, randomised, double-blind, placebo-controlled crossover trial
Lancet Respir Med. 2023 Aug 31:S2213-2600(23)00226-6. doi: 10.1016/S2213-2600(23)00226-6. Online ahead of print.ABSTRACTBACKGROUND: Mucociliary clearance is dysfunctional in people with primary ciliary dyskinesia, resulting in the accumulation of dehydrated mucus in the airways that is difficult to clear. We undertook a study to assess the benefit on lung function of treatment with a nebulised epithelial sodium channel (ENaC) blocker, idrevloride, with or without hypertonic saline, in people with primary ciliary dyskinesia.METHODS: The CLEAN-PCD trial was a phase 2, randomised, double-blind, placebo-controlled crossover tr...
Source: Respiratory Care - September 3, 2023 Category: Respiratory Medicine Authors: Felix C Ringshausen Adam J Shapiro Kim G Nielsen Henryk Mazurek Massimo Pifferi Karl H Donn Menno M van der Eerden Michael R Loebinger Maimoona A Zariwala Margaret W Leigh Michael R Knowles Thomas W Ferkol CLEAN-PCD investigators and study team Source Type: research
Systematic study of the synergistic and kinetics effects on the removal of contaminants of emerging concern from water by ultrasound in the presence of diverse oxidants
Environ Sci Pollut Res Int. 2023 Aug 26. doi: 10.1007/s11356-023-29189-y. Online ahead of print.ABSTRACTThe enhancement of the ultrasound system by adding diverse oxidants to remove a model contaminant (acetaminophen, ACE) in water was investigated. Different parameters were evaluated to study their effect on both the degradation kinetics and the synergy of the combination. The variables studied were the ultrasonic frequency (575, 858, and 1135 kHz), type of oxidant (hydrogen peroxide, sodium peroxydisulfate (or persulfate, PDS), and potassium peroxymonosulfate (PMS)), ACE concentration (4, 8, and 40 µM), and oxidant conc...
Source: Environmental Science and Pollution Research International - August 26, 2023 Category: Environmental Health Authors: Sandra E Estrada-Fl órez Efra ím A Serna-Galvis Judy Lee Ricardo A Torres-Palma Source Type: research
Long-term abuse of caffeine sodium benzoate induces endothelial cells injury and leads to coagulation dysfunction
IUBMB Life. 2023 Aug 19. doi: 10.1002/iub.2777. Online ahead of print.ABSTRACTOur hospital admitted a patient who had difficulty in coagulation even after blood replacement, and the patient had abused caffeine sodium benzoate (CSB) for more than 20 years. Hence, we aimed to explore whether CSB may cause dysfunction in vascular endothelial cells and its possible mechanism. Low, medium, and high concentrations of serum of long-term CSB intake patients were used to treat HUVECs, with LPS as the positive control. MTT and CCK8 were performed to verify CSB's damaging effect on HUVECs. The expression of ET-1, ICAM-1, VCAM-1, and ...
Source: Cancer Control - August 19, 2023 Category: Cancer & Oncology Authors: Tianwei Yu Hongwei Wang Rong Guo Jianzhong Liu Lili Tian Suri Guga Weixin Li Huiying Zhao Feiya Suo Hao Yang Quanzhi Yan Source Type: research
A novel approach to seizures in neonates
Eur J Paediatr Neurol. 2023 Jul 27;46:89-97. doi: 10.1016/j.ejpn.2023.07.006. Online ahead of print.ABSTRACTTHE CHALLENGE OF SEIZURE RECOGNITION: Recognition of seizures in neonates remains the foremost challenge to overcome. All neonates at risk for seizures, especially the critically ill, should undergo video-EEG monitoring. The initial step toward an accurate diagnosis is the accurate description and interpretation of the electro-clinical phenotype. THE IMPORTANCE OF SEIZURE SEMIOLOGY AND ASSOCIATION WITH ETIOLOGY: The early distinction between acute provoked seizures and neonatal-onset epilepsies serves as the primary ...
Source: European Journal of Paediatric Neurology - August 6, 2023 Category: Neurology Authors: Evelina Carapancea Maria Roberta Cilio Source Type: research
Effects of Triamterene in Hospitalized Patients with Heart Failure and Diuretic Resistance: A Randomized Clinical Trial
This study did not support the use of triamterene as an add-on therapy for patients with HF-related diuretic resistance. This article is protected by copyright. All rights reserved.PMID:37493211 | DOI:10.1002/jcph.2321
Source: The Journal of Clinical Pharmacology - July 26, 2023 Category: Drugs & Pharmacology Authors: Mohammadreza Taban-Sadeghi Elnaz Khani Kimia Khezripour Elgar Enamzadeh Naser Safaei Taher Entezari-Maleki Source Type: research
Efficacy of Peracetic Acid and Sodium Hypochlorite against SARS-CoV-2 on Contaminated Surfaces
The objectives of this study were to investigate the virucidal efficacy of NaOCl and PAA against SARS-CoV-2 using the ASTM standard methods. In the suspension assay, NaOCl and PAA (5, 50, and 200 ppm) were tested against SARS-CoV-2 in the presence/absence of soil load after 1 min of contact time. In the carrier assay, NaOCl and PAA were tested at 200, 400, 600, and 1,000 ppm for 1 min and 200 and 1,000 ppm for 5 and 10 min. Stainless steel (SS) and high-density polyethylene (HDPE) disks were used as carriers. The virus was suspended in soil load and the disinfectants were prepared in 300 ppm of hard water. Virus quantifica...
Source: Applied and Environmental Microbiology - June 22, 2023 Category: Microbiology Authors: J N Morris M A Esseili Source Type: research
