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Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Assessment of diphenhydramine toxicity - Is its mode of action conserved between human and zebrafish?
Environ Int. 2022 Apr 25;164:107263. doi: 10.1016/j.envint.2022.107263. Online ahead of print.ABSTRACTThe main aim of the study is to evaluate the effects of the pharmaceutical diphenhydramine (DPH) on embryo-larvae Danio rerio across distinct levels of organization - individual and subcellular - and correlate those effects with the DPH mode of action (MoA) assessed by in silico analysis. An embryos heartbeat rate reduction was observed at 10 mg/L DPH, but 0.001 to 10 mg/L did not significantly affect the zebrafish survival, hatching and morphology. Larvae swimming distance decreased (hypoactivity) at 1 and 10 mg/L DPH. Mo...
Source: Environment International - May 3, 2022 Category: Environmental Health Authors: Angela Barreto Joana Santos Ana Capit ão Rodrigo Eus ébio Évila Pinheiro Damasceno Ana Lu ísa Machado Luciana S Rocha V ânia Calisto M ónica J B Amorim Vera L Maria Source Type: research
Physiological and biochemical response of the solitary bee Osmia bicornis exposed to three insecticide-based agrochemicals
Ecotoxicol Environ Saf. 2021 Dec 22;230:113095. doi: 10.1016/j.ecoenv.2021.113095. Online ahead of print.ABSTRACTThe physiological and biochemical stress induced by pesticides need to be addressed in economically and ecologically important non-Apis solitary bees, particularly at lower than field-applied concentrations. Thus, the aim of the present study was to analyse the physiological and biochemical changes in female adult Osmia bicornis bees upon continuous oral exposure to three insecticide-based agrochemicals - i.e. Dursban 480 EC (active ingredient - a.i. chlorpyrifos), Sherpa 100 EC (a.i. cypermethrin), and Mospilan...
Source: Ecotoxicology and Environmental Safety - December 25, 2021 Category: Environmental Health Authors: Jaya Sravanthi Mokkapati Agnieszka J Bednarska Ryszard Laskowski Source Type: research
Toxicity of boron and vanadium nanoparticles on Danio rerio embryos - Phenotypical, biochemical, and behavioral alterations
Aquat Toxicol. 2021 Jul 31;238:105930. doi: 10.1016/j.aquatox.2021.105930. Online ahead of print.ABSTRACTEngineered nanoparticles (NPs) are emerging contaminants of concern and it is important to understand their environmental behavior and ecological risks to exposed organisms. Despite their ubiquitous presence in the environment, there is little information about the hazards of certain NPs, such as boron (BNPs) and vanadium (VNPs). The aim of the present research was to investigate the effects of commercial BNPs and VNPs (80 to 100 nm) to zebrafish embryos, at different levels of biological organization. A range of nomina...
Source: Aquatic Toxicology - August 7, 2021 Category: Toxicology Authors: Joana Santos Ângela Barreto C élia Almeida C átia Azevedo In ês Domingues M ónica J B Amorim Vera L Maria Source Type: research
Effects of zinc toxicity on the nitrogen-fixing cyanobacterium Anabaena sphaerica-ultastructural, physiological and biochemical analyses
Environ Sci Pollut Res Int. 2021 Feb 27. doi: 10.1007/s11356-021-12882-1. Online ahead of print.ABSTRACTThe current study describes the mechanisms of zinc toxicity in the cyanobacterium Anabaena sphaerica after eight days treatment with 10 mg L-1 ZnCl2. The application of zinc not only showed elevated accumulation of the metal inside the cells but also exhibited devastating impacts on the cell numbers, morphology, and ultrastructure of A. sphaerica. The effects of zinc on the pigments contents, oxygen evolution rate, Fv/Fm, electron transport rate, and carbohydrate content were also evaluated in A. sphaerica. Moreover, zin...
Source: Environmental Science and Pollution Research International - February 27, 2021 Category: Environmental Health Authors: Sindhunath Chakraborty Arun Kumar Mishra Source Type: research
Informatics and Computational Methods in Natural Product Drug Discovery: A Review and Perspectives
Joseph D. Romano1,2,3,4 and Nicholas P. Tatonetti1,2,3,4*
1Department of Biomedical Informatics, Columbia University, New York, NY, United States
2Department of Systems Biology, Columbia University, New York, NY, United States
3Department of Medicine, Columbia University, New York, NY, United States
4Data Science Institute, Columbia University, New York, NY, United States
The discovery of new pharmaceutical drugs is one of the preeminent tasks—scientifically, economically, and socially—in biomedical research. Advances in informatics and computational biology have increased productivity at many ...
Source: Frontiers in Genetics - April 29, 2019 Category: Genetics & Stem Cells Source Type: research
Fight Aging! Newsletter, July 2nd 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
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Source: Fight Aging! - July 1, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
