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Total 44 results found since Jan 2013.
A deep learning-based drug repurposing screening and validation for anti-SARS-CoV-2 compounds by targeting the cell entry mechanism
Biochem Biophys Res Commun. 2023 Jul 12;675:113-121. doi: 10.1016/j.bbrc.2023.07.018. Online ahead of print.ABSTRACTThe recent outbreak of Corona Virus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a severe threat to the global public health and economy, however, effective drugs to treat COVID-19 are still lacking. Here, we employ a deep learning-based drug repositioning strategy to systematically screen potential anti-SARS-CoV-2 drug candidates that target the cell entry mechanism of SARS-CoV-2 virus from 2635 FDA-approved drugs and 1062 active ingredients from Tra...
Source: Biochemical and Biophysical Research communications - July 19, 2023 Category: Biochemistry Authors: Yingjia Yao Yunhan Zhang Zexu Li Zhisong Chen Xiaofeng Wang Zihan Li Li Yu Xiaolong Cheng Wei Li Wen-Jie Jiang Hua-Jun Wu Zezhong Feng Jinfu Sun Teng Fei Source Type: research
The development of carbohydrate polymer- and protein-based biomaterials and their role in environmental health and hygiene: A review
Int J Biol Macromol. 2023 May 15:124875. doi: 10.1016/j.ijbiomac.2023.124875. Online ahead of print.ABSTRACTBiological macromolecules have been significantly used in the medicine due to their certain therapeutic values. Macromolecules have been employed in medical filed in order to enhance, support, and substitute damaged tissues or any other biological function. In the past decade, the biomaterial field has developed considerably because of vast innovations in regenerative medicine, tissue engineering, etc. Different types of biological macromolecules such as natural protein and polysaccharide etc. and synthetic molecules...
Source: International Journal of Biological Macromolecules - May 17, 2023 Category: Biochemistry Authors: Manita Thakur Manisha Chandel Ajay Kumar Sarita Kumari Pawan Kumar Deepak Pathania Source Type: research
Understanding old herbal secrets: The renaissance of traditional medicinal plants beyond the twenty classic species?
Front Pharmacol. 2023 Mar 24;14:1141044. doi: 10.3389/fphar.2023.1141044. eCollection 2023.ABSTRACTThe use of traditional medicinal plants plays an important role especially in remote rural and marginalized landscapes at different latitudes. In the development of nature conservation strategies based on local knowledge and sustainable resource management, medicinal herbs have been hypothesized to be cultural key stone species. Environmental education is a crucial driver for fostering environmental literacy and preserving local knowledge across generations. We conducted semi-structured interviews with stakeholders in the Aut...
Source: Rural Remote Health - April 10, 2023 Category: Rural Health Authors: Marisa Milena Scherrer Stefan Zerbe Joshua Petelka Ina S äumel Source Type: research
Traditional Chinese Medicine as the preventive and therapeutic remedy for COVID-19
This article explored the Chinese national authorities' guidelines from 2003 to 2020, the scientific data in public databases for the recommended TCM remedies, and their potential mechanistic actions in COVID-19 management. Several TCM herbs and formulations could potentially benefit COVID-19 management. The recommended TCM oral preparations list are Huoxiang zhengqi, Jinhua Qinggan, Lianhua Qingwen, and Shufeng jiedu; the recommended injection preparations comprise Xiyanping Xuebijing, Re-Du-Ning, Tanreqing, Xingnaojing, Shenfu, Shengmai, and Shenmai. TCM remedies are viable options for symptom alleviation and management ...
Source: Current Medicinal Chemistry - March 31, 2023 Category: Chemistry Authors: Amin Gasmi Torsak Tippairote Pavan Kumar Mujawdiya Alain Menzel Roman Lysiuk Mariia Shanaida Larysa Lenchyk Massimiliano Peana Geir Bj ørklund Source Type: research
Secondary plant metabolites as potent drug candidates against antimicrobial-resistant pathogens
SN Appl Sci. 2022;4(8):209. doi: 10.1007/s42452-022-05084-y. Epub 2022 Jul 8.ABSTRACTAntibiotic resistance is a major public health threat of the twenty-first century and represents an important risk to the global economy. Healthcare-associated infections mainly caused by drug-resistant bacteria are wreaking havoc in patient care worldwide. The spread of such pathogens limits the utility of available drugs and complicates the treatment of bacterial diseases. As a result, there is an urgent need for new drugs with mechanisms of action capable of curbing resistance. Plants synthesize and utilize various metabolic compounds t...
Source: Appl Human Sci - July 13, 2022 Category: Physiology Authors: Kadiatou Keita Charles Darkoh Florence Okafor Source Type: research
