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Specialty: Drugs & Pharmacology
Therapy: Dialysis
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Total 318 results found since Jan 2013.
Nitric oxide in kidney transplantation
Biomed Pharmacother. 2023 Sep 16;167:115530. doi: 10.1016/j.biopha.2023.115530. Online ahead of print.ABSTRACTKidney transplantation is the treatment of choice for patients with kidney failure. Compared to dialysis therapy, it provides better quality of life and confers significant survival advantage at a relatively lower cost. However, the long-term success of this life-saving intervention is severely hampered by an inexorable clinical problem referred to as ischemia-reperfusion injury (IRI), and increases the incidence of post-transplant complications including loss of renal graft function and death of transplant recipie...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2023 Category: Drugs & Pharmacology Authors: George J Dugbartey Source Type: research
Preparation and in Vitro/In Vivo Characterization of Sustained-Release Ciprofloxacin-Carrageenan Complex
Eur J Pharm Biopharm. 2023 Aug 22:S0939-6411(23)00215-1. doi: 10.1016/j.ejpb.2023.08.012. Online ahead of print.ABSTRACTThe goal of the study was to look into drug-polyelectrolyte complexation between ciprofloxacin (Cipro) and λ-carrageenan (CRG), and to employ the complex as a sustained-release matrix. The maximum binding capacity of the complexation was determined using the dialysis bag method and employed to prepare the complex. In comparison to Cipro, CRG, and their physical mixing, the complex was examined using differential scanning calorimetry, Fourier infrared spectroscopy, powder X-ray diffraction, and scanning e...
Source: European Journal of Pharmaceutics and Biopharmaceutics - August 24, 2023 Category: Drugs & Pharmacology Authors: Samaa Abdullah Ahmad Bani-Jaber Nabil A Alhakamy Yahya F Jamous Alaa A Al-Masud Meshal Marzoog Al-Sharafa Source Type: research
High glucose dialysate-induced peritoneal fibrosis: Pathophysiology, underlying mechanisms and potential therapeutic strategies
Biomed Pharmacother. 2023 Jul 29;165:115246. doi: 10.1016/j.biopha.2023.115246. Online ahead of print.ABSTRACTPeritoneal dialysis is an efficient renal replacement therapy for patients with end-stage kidney disease. However, continuous exposure of the peritoneal membrane to dialysate frequently leads to peritoneal fibrosis, which alters the function of the peritoneal membrane and results in withdrawal from peritoneal dialysis in patients. Among others, high glucose dialysate is considered as a predisposing factor for peritoneal fibrosis in patients on peritoneal dialysis. Glucose-induced inflammation, metabolism disturbanc...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 31, 2023 Category: Drugs & Pharmacology Authors: Hanxue Zhao Hong-Liang Zhang Linpei Jia Source Type: research
Comorbidity and in-hospital mortality in peritoneal dialysis patients: data of the Emilia Romagna region of Italy
CONCLUSIONS: We conclude that in male, elderly hospitalized peritoneal dialysis patients with failing dialysis technique, comorbidity burden should be considered being a predictor of IHM.PMID:37522699 | DOI:10.26355/eurrev_202307_33158
Source: Pharmacological Reviews - July 31, 2023 Category: Drugs & Pharmacology Authors: F Fabbian A De Giorgi F Ferrara G Alfano G Mori A Di Maria M Frisina M Veronesi A Storari G Donati Source Type: research
High glucose dialysate-induced peritoneal fibrosis: Pathophysiology, underlying mechanisms and potential therapeutic strategies
Biomed Pharmacother. 2023 Jul 29;165:115246. doi: 10.1016/j.biopha.2023.115246. Online ahead of print.ABSTRACTPeritoneal dialysis is an efficient renal replacement therapy for patients with end-stage kidney disease. However, continuous exposure of the peritoneal membrane to dialysate frequently leads to peritoneal fibrosis, which alters the function of the peritoneal membrane and results in withdrawal from peritoneal dialysis in patients. Among others, high glucose dialysate is considered as a predisposing factor for peritoneal fibrosis in patients on peritoneal dialysis. Glucose-induced inflammation, metabolism disturbanc...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 31, 2023 Category: Drugs & Pharmacology Authors: Hanxue Zhao Hong-Liang Zhang Linpei Jia Source Type: research
Overview of the Treatment of Congestion in Heart Failure
CONCLUSION: Despite the significant amount of research published in recent years, there are no clear algorithms for managing acute heart failure. Diuretics remain the primary treatment of acute heart failure, and nephron blockade is key, but new therapies are emerging, and ongoing research is needed to develop better strategies for managing this condition.PMID:37455461 | DOI:10.2174/1381612829666230714153404
Source: Current Pharmaceutical Design - July 17, 2023 Category: Drugs & Pharmacology Authors: Martinez-Sole Julia Sanchez-Martinez Jose Carlos Lopez-Vilella Raquel Donoso-Trenado Victor Sanchez-Lazaro Ignacio Almenar-Bonet Luis Sanz-Sanchez Jorge Martinez-Dolz Luis Source Type: research
Achieving Good Metabolic Control Without Weight Gain with the Systematic Use of GLP-1-RAs and SGLT-2 Inhibitors in Type 2 Diabetes: A Machine-Learning Projection Using Data from Clinical Practice
Clin Ther. 2023 Jul 12:S0149-2918(23)00201-1. doi: 10.1016/j.clinthera.2023.06.006. Online ahead of print.ABSTRACTPURPOSE: Recently, the 2022 American Diabetes Association and European Association for the Study of Diabetes (ADA-EASD) consensus report stressed the importance of weight control in the management of patients with type 2 diabetes; weight control should be a primary target of therapy. This retrospective analysis evaluated, through an artificial-intelligence (AI) projection of data from the AMD Annals database-a huge collection of most Italian diabetology medical records covering 15 years (2005-2019)-the potentia...
Source: Clinical Therapeutics - July 14, 2023 Category: Drugs & Pharmacology Authors: Carlo Bruno Giorda Antonio Rossi Fabio Baccetti Rita Zilich Francesco Romeo Nreu Besmir Graziano Di Cianni Giacomo Guaita Lelio Morviducci Marco Muselli Alessandro Ozzello Federico Pisani Paola Ponzani Pierluigi Santin Damiano Verda Nicoletta Musacchio Source Type: research
Hyperlipoproteinemia (a) and Phytoestrogen Therapy in Dialysis Patients: A Review
Clin Ther. 2023 Jul 11:S0149-2918(23)00222-9. doi: 10.1016/j.clinthera.2023.06.017. Online ahead of print.ABSTRACTPURPOSE: Hyperlipoproteinemia (a) is a prevalent complication in dialysis patients, with no valid treatment strategy. The aim of this narrative review was to investigate the clinical significance of hyperlipoproteinemia (a) and phytoestrogen therapy in dialysis patients.METHODS: A comprehensive literature search of the published data was performed regarding the effects of phytoestrogen therapy on hyperlipoproteinemia (a) in dialysis patients.FINDINGS: Hyperlipoproteinemia (a) occurs in dialysis patients due to ...
Source: Clinical Therapeutics - July 13, 2023 Category: Drugs & Pharmacology Authors: Hadi Tabibi Zahra Yari Source Type: research
DIALIZE China: A Phase IIIb, Randomized, Placebo-Controlled Study to Reduce Predialysis Hyperkalemia With Sodium Zirconium Cyclosilicate in Chinese Patients
Clin Ther. 2023 Jun 27:S0149-2918(23)00153-4. doi: 10.1016/j.clinthera.2023.04.014. Online ahead of print.ABSTRACTPURPOSE: The DIALIZE China study (Reduce Incidence of Pre-Dialysis Hyperkalaemia With Sodium Zirconium Cyclosilicate in Chinese Subjects) (NCT04217590) evaluated sodium zirconium cyclosilicate (SZC) for the management of hyperkalemia in Chinese patients undergoing hemodialysis.METHODS: In the double-blind, Phase IIIb DIALIZE China study, Chinese adults with kidney failure and predialysis hyperkalemia (predialysis serum potassium [sK+] concentration >5.4 mmol/L after the long interdialytic interval [LIDI] and...
Source: Clinical Therapeutics - June 29, 2023 Category: Drugs & Pharmacology Authors: Zhaohui Ni Renhua Lu Xudong Xu Xueyan Bian Zhihong Zhou Junwei Yang Qun Luo Menghua Chen Chaosheng Chen Xiuli Sun Lei Yu Qiang He Hong Jiang Weijie Yuan Yi Li Rong Zhou Jianqin Wang Xinzhou Zhang Li Zuo Xiangwen Meng Zhiren Chang June Zhao Peter Wessman P Source Type: research
