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Therapy: Cancer Therapy
Nutrition: Probiotics
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Total 77 results found since Jan 2013.
Faecalibacterium prausnitzii abrogates intestinal toxicity and promotes tumor immunity to increase the efficacy of dual CTLA-4 and PD-1 checkpoint blockade
Cancer Res. 2023 Aug 21:CAN-23-0605. doi: 10.1158/0008-5472.CAN-23-0605. Online ahead of print.ABSTRACTImmune checkpoint inhibitors (ICIs) have revolutionized cancer therapy; however, their application is limited by the occurrence of immune-related adverse events. The gut microbiota plays important roles in the response to and toxicity of immunotherapy, and Faecalibacterium prausnitzii (F. prausnitzii) has been shown to possess immunomodulatory potential. Here, we found that patients receiving ICIs who developed colitis had a lower abundance of F. prausnitzii. In vivo, immunocompetent mice administered with dextran sodium ...
Source: Cell Research - August 21, 2023 Category: Cytology Authors: Yaqi Gao Pingping Xu Danfeng Sun Yi Jiang Xiaolin Lin Ting Han Jun Yu Chunquan Sheng Hao-Yan Chen Jie Hong Yingxuan Chen Xiu-Ying Xiao Jing-Yuan Fang Source Type: research
Exploring the complex and multifaceted interplay of the gut microbiome and cancer prevention and therapy
Acta Microbiol Immunol Hung. 2023 Jun 12;70(2):85-99. doi: 10.1556/030.2023.02054. Print 2023 Jun 16.ABSTRACTRecent scientific research has indicated that the gut microbiota constitutes a nuanced, diverse ecosystem of microorganisms that have gained significant attention due to its crucial involvement in shaping human health and diseases. In particular, the gut microbiota plays a pivotal role in cancer prevention, and disturbances in its composition and function, known as dysbiosis, that have been linked to an increased risk of developing various malignancies. The gut microbiota exerts a myriad of effects on the production...
Source: Acta Microbiologica et Immunologica Hungarica - June 12, 2023 Category: Microbiology Authors: Sukrit Kashyap Asmita Das Source Type: research
Fabrication of a microfluidic device for probiotic drug's dosage screening: Precision Medicine for Breast Cancer Treatment
Transl Oncol. 2023 May 22;34:101674. doi: 10.1016/j.tranon.2023.101674. Online ahead of print.ABSTRACTBreast cancer is the most common cancer in women; it has been affecting the lives of millions each year globally and microfluidic devices seem to be a promising method for the future advancements in this field. This research uses a dynamic cell culture condition in a microfluidic concentration gradient device, helping us to assess breast anticancer activities of probiotic strains against MCF-7 cells. It has been shown that MCF-7 cells could grow and proliferate for at least 24 h; however, a specific concentration of probio...
Source: Translational Oncology - May 24, 2023 Category: Cancer & Oncology Authors: Ali Salehi Parvaneh Naserzadeh Parastoo Tarighi Elham Afjeh-Dana Masoud Akhshik Amir Jafari Pooyan Mackvandi Behnaz Ashtari Masoud Mozafari Source Type: research
Lactobacillus  rhamnosus GG cell-free supernatant as a novel anti-cancer adjuvant
CONCLUSION: Overall, our results suggest that LGG-SN may contain one or more bioactive molecules with anti-cancer activity which sensitize cancer cells to chemotherapeutic drugs. Thus, LGG could be proposed as an ideal candidate for ground-breaking integrated approaches to be employed in oncology, to reduce chemotherapy-related side effects and overcome resistance or relapse issues, thus ameliorating the therapeutic response in cancer patients.PMID:36918929 | DOI:10.1186/s12967-023-04036-3
Source: Cancer Control - March 15, 2023 Category: Cancer & Oncology Authors: Rossella Salemi Silvia Vivarelli Daria Ricci Marina Scillato Maria Santagati Giuseppe Gattuso Luca Falzone Massimo Libra Source Type: research
Nutritional interventions for the prevention and treatment of cancer therapy-induced oral mucositis: an umbrella review of systematic reviews and meta-analysis
CONCLUSION: This umbrella review shows that honey, glutamine, and propolis can significantly reduce the incidence of severe OM. These findings need to be confirmed with well-designed, longitudinal randomized controlled trials.SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42022301010.PMID:36763701 | DOI:10.1093/nutrit/nuac105
Source: Cancer Control - February 10, 2023 Category: Cancer & Oncology Authors: Reza Amiri Khosroshahi Sepide Talebi Sheida Zeraattalab-Motlagh Hossein Imani Amirabbas Rashidi Nikolaj Travica Hamed Mohammadi Source Type: research
An In Vivo Study of < em > Lactobacillus rhamnosus < /em > (PTCC 1637) as a New Therapeutic Candidate in Esophageal Cancer
CONCLUSION: This study is the first report that assessed the potential impact of L. rhamnosus, especially its supernatant on esophageal cancer and Wnt signaling pathway genes. Therefore, this bacterium can be a harmless candidate for esophageal cancer therapy.PMID:35782061 | PMC:PMC9249511 | DOI:10.1155/2022/7607470
Source: Biomed Res - July 5, 2022 Category: Research Authors: Malihe-Sadat Hashemi-Khah Nazila Arbab-Soleimani Mohammad-Mahdi Forghanifard Omid Gholami Saba Taheri Sakineh Amoueian Source Type: research
