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Current Drug Treatment Strategies for Atrial Fibrillation and TASK-1 Inhibition as an Emerging Novel Therapy Option
Atrial fibrillation (AF) is the most common sustained arrhythmia with a prevalence of up to 4% and an upwards trend due to demographic changes. It is associated with an increase in mortality and stroke incidences. While stroke risk can be significantly reduced through anticoagulant therapy, adequate treatment of other AF related symptoms remains an unmet medical need in many cases. Two main treatment strategies are available: rate control that modulates ventricular heart rate and prevents tachymyopathy as well as rhythm control that aims to restore and sustain sinus rhythm. Rate control can be achieved through drugs or abl...
Source: Frontiers in Pharmacology - March 4, 2021 Category: Drugs & Pharmacology Source Type: research

Therapeutic advances in Fabry disease: The future awaits.
Abstract Fabry disease (FD) is an X-linked disorder caused by mutations in GLA gene responsible for coding of the lysosomal enzyme alpha-galactosidase A(α-GAL). The resultant accumulation of globotriaosylceramide (Gb-3) leads to multisystemic disease including progressive chronic kidney disease, hypertrophic cardiomyopathy, stroke, angiokeratomas and corneal whorls. Current treatments include enzyme replacement therapy (ERT), along with recent advent of chaperone therapy. ERT has not shown to have dramatic improvement in outcomes for all organ systems, with benefit mostly seen in kidney disease and reduction in l...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 1, 2020 Category: Drugs & Pharmacology Authors: Kant S, Atta MG Tags: Biomed Pharmacother Source Type: research

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP β/ζ Axis: Relevance in Therapeutic Development
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroi...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Current and promising therapies in autosomal recessive ataxias.
CONCLUSION: The aim of this review is to provide a comprehensive clinical profile and to review the current available therapies. We overview the physiopathology, neurological features and diagnostic approach of the common recessive ataxias. The emphasis is also put on potential drugs currently or soon-to-be in clinical trials. Promising gene therapies raise the possibility of treating specifically Friedreich's ataxia, Ataxia-telangiectasia, Wilson's disease and Niemann-Pick disease in the next few years. PMID: 29676235 [PubMed - as supplied by publisher]
Source: CNS and Neurological Disorders Drug Targets - April 18, 2018 Category: Drugs & Pharmacology Authors: Picher-Martel V, Dupre N Tags: CNS Neurol Disord Drug Targets Source Type: research

Triple-Gene Therapy for Stroke: A Proof-of-Concept in Vivo Study in Rats
Mikhail E. Sokolov, Farid V. Bashirov, Vage A. Markosyan, Tatyana V. Povysheva, Filip O. Fadeev, Andrey A. Izmailov, Maxim S. Kuztetsov, Zufar Z. Safiullov, Maxim M. Shmarov, Boris S. Naroditskyi, Andr ás Palotás, Rustem R. Islamov
Source: Frontiers in Pharmacology - February 15, 2018 Category: Drugs & Pharmacology Source Type: research

Nanocarriers as treatment modalities for hypertension.
Authors: Alam T, Khan S, Gaba B, Haider MF, Baboota S, Ali J Abstract Hypertension, a worldwide epidemic at present, is not a disease in itself rather it is an important risk factor for serious cardiovascular disorders including myocardial infarction, stroke, heart failure, and peripheral artery disease. Though numerous drugs acting via different mechanism of action are available in the market as conventional formulations for the treatment of hypertension but they face substantial challenges regarding their bioavailability, dosing and associated adverse effects which greatly limit their therapeutic efficacies. Vari...
Source: Drug Delivery - February 8, 2017 Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research

Delivery of Hypoxia-Inducible Heme Oxygenase-1 Gene for Site-Specific Gene Therapy in the Ischemic Stroke Animal Model
Conclusions pEpo-SV-HO-1 induced HO-1 gene expression and therapeutic effect in the ischemic brain. Therefore, pEpo-SV-HO-1 may be useful for site-specific gene therapy of ischemic stroke.
Source: Pharmaceutical Research - July 30, 2016 Category: Drugs & Pharmacology Source Type: research