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All That Glitters Is not Gold: Peals and Pitfalls in I-131 Scans for Differentiated Thyroid Cancer
Conclusion: We review thyroid gland physiology and describe a systemic overview of potential false positive and false negative lack of uptake of radioiodine in the whole body along with illustrations and cases. By understanding the physiology and characteristics of radioiodine uptake and correlating with anatomical imaging, biochemical data, and clinical findings, physicians can be more confident in establishing proper management for patients with DTC using radioiodine whole body scans. Research Support: N/A
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Lazaga, F., Sharma, S., Sharma, P., Williams, S. Tags: Educational Exhibits Posters Source Type: research

Microglial activation in recent ischemic stroke: comparison of two TSPO tracers
Conclusion: The apparent intensity of microglial activation in ischemic stroke is closely comparable between 18F-GE180 and 11C-(R)-PK11195 PET. Research Support: The study is funded by a grant from NIHR and supported by GEHC and INMIND (EC FP7).
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Herholz, K., Hinz, R., Visi, E., Trigg, W., McDonald, K., Punter, M., Majid, A., Gerhard, A. Tags: Neurology Posters Source Type: research

18F-NaF PET Demonstrating Unusual Focal Tracer Activity in the Brain
Abstract: A 60-year-old man with enlarged prostate, hypertension, and diabetes was referred for 18F-NaF PET/CT to evaluate possible metastatic lesions. The patient appeared asymptomatic on the day of the study, without any signs indicating stroke. Patient also had no known history of malignancy or cerebrovascular disease. He had mild elevation of the prostate-specific antigen level, and biopsy of his prostate was not performed. Patient had long-standing history of chronic back pain and abdominal pain. The PET bone scan demonstrated a large area of very intense tracer uptake in the brain. A subsequent brain MRI revealed pri...
Source: Clinical Nuclear Medicine - January 10, 2017 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Role of quantitative myocardial positron emission tomography for risk stratification in patients with hypertrophic cardiomyopathy: a 2016 reappraisal
ConclusionsDip-MBF confirms its role as potent predictor of outcome in HCM. However, the threshold for prediction in a contemporary cohort is higher than that reported in earlier studies. Dip-MBF impairment in the lateral wall, possibly reflecting diffuse disease extending to non-hypertrophic regions, is a sensitive predictor of mortality in HCM.
Source: European Journal of Nuclear Medicine and Molecular Imaging - November 3, 2016 Category: Nuclear Medicine Source Type: research

Subacute Stroke Mimicking Cerebral Metastasis in 68Ga-PSMA-HBED-CC PET/CT
Abstract: A 65-year-old man with disseminated bone metastases of prostate cancer was referred for 68Ga-PSMA-HBED-CC-PET/CT (short PSMA-PET/CT) to exclude visceral metastases before treatment of bone metastases with 223Ra-dichloride. Apart from disseminated bone metastases, PSMA-PET/CT revealed a focal cerebral tracer uptake in the right frontal lobe highly suspicious for cerebral spread. According to patient history, a cerebral infarction occurred 14 days before PSMA imaging in corresponding localization confirmed by MRI scanning. This case demonstrates the possibility of false-positive finding of cerebral metastases in PS...
Source: Clinical Nuclear Medicine - September 8, 2016 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Automatic Extraction of Myocardial Mass and Volume Using Parametric Images from Dynamic Nongated PET
Conclusion: LV mass and volume are accurately and automatically generated from dynamic 11C-acetate PET without electrocardiogram gating. This method can be incorporated in a standard routine without any additional workload and can, in theory, be extended to other PET tracers.
Source: Journal of Nuclear Medicine - August 31, 2016 Category: Nuclear Medicine Authors: Harms, H. J., Stubkjaer Hansson, N. H., Tolbod, L. P., Kim, W. Y., Jakobsen, S., Bouchelouche, K., Wiggers, H., Frokiaer, J., Sorensen, J. Tags: Clinical Investigations Source Type: research

Automatic calculation of myocardial external efficiency using a single 11C-acetate PET/CT scan: a dual-center validation
Conclusions Myocardial efficiency can be calculated automatically using only a single 11C-acetate PET scan. This facilitates clinical applicability and provides unbiased access to a sensitive marker of cardiac dysfunction.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Harms, H. J., Hansson, N., Kero, T., A-rndahl, L., Kim, Y., Frokiaer, J., Wiggers, H., Flachskampf, F., Tolbod, L., Sorensen, J. Tags: MTA II: Cardiovascular Clinical Science Posters Source Type: research

Causal role of non-stenotic hypodense plaques with high FDG uptake detected with PET-CT angiography in patients with unknown cause of stroke?
Conclusions In this exploratory study, we found a high prevalence of non-stenotic hypodense plaques with high FDG uptake (TBR max. > 1.80) in carotid arteries ipsilateral to cerebral ischemia suggesting a causal role for these plaque in patients with unknown cause of stroke. In comparison to high-resolution MRI, the imaging criteria used in this study for the identification of complicated plaques were very simple and easy to implement. In addition, FDG-PET-CTA allows for the evaluation of non-stenotic plaques along the whole length of supra-aortic trunks. Further studies with a larger number of patients are requested to...
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Mikail, N., Mazighi, M., Meseguer, E., Guidoux, C., Leseche, G., Rouzet, F., Le Guludec, D., Amarenco, P., Hyafil, F. Tags: MTA II: Cardiovascular Clinical Science Posters Source Type: research

18FFDPN for PET Imaging of Soluble Epoxide Hydrolase (sEH)
Conclusions [18F]FDPN, a potent sEH inhibitor, readily enters the mouse and baboon brain and radiolabels sEH with high specificity (up to 95%) in both species. This first-in-class agent may enable study of sEH non-invasively in a variety of neurological diseases.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Horti, A., Wang, Y., Minn, I., Koehler, R., Dannals, R., Pomper, M. Tags: Neurosciences - Basic Science 1 Source Type: research

Periodontitis and carotid arterial inflammation
Conclusions Independent of systemic inflammation, these data suggest that periodontitis and its degree of inflammation appear to be closely associated with vascular inflammation, a crucial mechanism of the development, progression and vulnerability of atherosclerotic plaque.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Cho, J., Choe, J. G., Rhee, S., Choi, S., Eo, J. S., Kim, S. Tags: MTA II: Cardiovascular Clinical Science Posters Source Type: research

Assessment of muscle function using hybrid pet/mri: comparison of quantifying muscle activation using 18f-fdg pet and t2 mri in human subjects
Conclusions There exists a strong linear correlation between T2 changes and glucose uptake which did not vary between subjects nor between muscle groups. This is the first assessment of skeletal muscle function using hybrid PET/MRI and the first study to demonstrate the correlation between [18F]-FDG uptake and changes in muscle T2 with physical exercise. Accordingly, it seems that changes in muscle T2 may be used as a surrogate marker for glucose uptake. Such metabolic information of muscle activation could lead to an improved insight and to improved treatment strategies in neuromuscular pathologies such as stroke, spinal ...
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Haddock, B. Tags: Musculoskeletal 1 Source Type: research

Brain findings on FDG PET-MRI body sequences that include the head
Conclusions FDG PET-MRI imaging is a rapidly evolving modality that is most commonly employed for cancer evaluation. The standardized base of skull to mid thigh imaging may miss many important pathologies that are discovered even with MRI body sequences. We propose that PET-MRI body sequences that include the head may show added value in the management of patients.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Franceschi, A., Matthews, R., Bangiyev, L., Relan, N., Chaudhry, A., Franceschi, D. Tags: Outcomes/Comparative Effectiveness Research & amp; Radiation Safety Source Type: research

18FFLT - A new stem cell label for in vivo tracking with positron emission tomography
Conclusions In conclusion, [18F]FLT labeling of sheep MSCs is feasible. 60min incubation time with the tracer does not perturb the biologic and functional properties of adult sheep MSCs in vitro. This labeling method and optimization strategy has led to pilot studies investigating the biodistribution of [18F]FLT-labeled MSCs in mice using small-animal PET/MRI. Future studies will also determine whether [18F]FLT-labeled MSCs can be tracked over time in a large animal model to assess the therapeutic potential of MSCs after stroke.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: GroAYmann, U., Zeisig, V., McLeod, D., Dreyer, A., Patt, M., Schildan, A., Sabri, O., Boltze, J., Barthel, H. Tags: SPECIAL MTA: Preclinical Probes for Neuroimaging Posters Source Type: research

Correlation between F-18 FDG FP-CIT and clinical findings in patients with Parkinsons disease
Conclusions Though striatal volume computed from F-18 FP-CIT PET using occipital lobe as a reference area decreased as the duration of Parkinson’s disease increased, the degree of correlation was weak. There was no statistically significant correlation between the PET parameters and UPDRS. Further studies are needed to determine how to best utilize quantitative F-18 FP-CIT PET in Parkinson’s disease.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Kim, H., O, J. H., Park, H., Han, E. J., Park, Y. H. Tags: MTA II: Neurology Posters Source Type: research

Clinical implications for Translocator Protein (TSPO) imaging using 123ICLINDE SPECT: A feasible approach
Conclusions The preliminary results imply that [123I]CLINDE-SPECT is a feasible approach for TSPO imaging in neurological disorders associated with microglial activation and/or increased TSPO expression. The development of methods that do not need arterial blood sampling for quantification of TSPO will be important to ease implementation in a daily clinical setting. Further clinical studies are needed to determine the precise role of TSPO imaging in predicting clinical outcome and treatment response.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Thomsen, G., Jensen, P., Feng, L., Knudsen, L., Knudsen, G., Pinborg, L. Tags: Neurosciences/Neurology. Miscellaneous Source Type: research

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