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Specialty: Cytology
Procedure: Gastroschisis Repair

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Total 85 results found since Jan 2013.

Secretome of endothelial progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage
CONCLUSION: Our results suggest that scCM promotes angiogenesis and the maturation of newly formed vessels while restoring the BBB function in ischemic conditions. In conclusion, our results highlight the possibility of using EPC-secretome as a therapeutic alternative to promote brain angiogenesis and protect from ischemia-induced vascular leakage.PMID:34702368 | DOI:10.1186/s13287-021-02608-y
Source: Cell Research - October 27, 2021 Category: Cytology Authors: Rodrigo Azevedo Loiola Miguel Garc ía-Gabilondo Alba Grayston Paulina Bugno Agnieszka Kowalska Sophie Duban-Deweer Eleonora Rizzi Johan Hachani Yasuteru Sano Fumitaka Shimizu Takashi Kanda Caroline Mysiorek Maciej Piotr Mazurek Anna Rosell Fabien Gossele Source Type: research

P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke
Cell Tissue Res. 2021 Oct 26. doi: 10.1007/s00441-021-03539-z. Online ahead of print.ABSTRACTStroke is the leading cause of adult disability. Endogenous neural stem/progenitor cells (NSPCs) originating from the subventricular zone (SVZ) contribute to the brain repair process. However, molecular mechanisms underlying CNS disease-induced SVZ NSPC-redirected migration to the lesion area are poorly understood. Here, we show that genetic depletion of the p75 neurotrophin receptor (p75NTR-/-) in mice reduced SVZ NSPC migration towards the lesion area after cortical injury and that p75NTR-/- NSPCs failed to migrate upon BDNF stim...
Source: Cell Research - October 26, 2021 Category: Cytology Authors: Sachin S Deshpande Subash C Malik Pasquale Conforti Jia-di Lin Yu-Hsuan Chu Suvra Nath Franziska Greulich Meike-Ast Dumbach N Henriette Uhlenhaut Christian Schachtrup Source Type: research

Delayed rFGF21 Administration Improves Cerebrovascular Remodeling and White Matter Repair After Focal Stroke in Diabetic Mice
This study aims to evaluate the potential effects of rFGF21 on cerebrovascular remodeling after T2DM stroke. Permanent distal middle cerebral artery occlusion was performed in heterozygous non-diabetic db/ + and homozygous diabetic db/db mice. Daily rFGF21 administration was initiated 1 week after stroke induction and maintained for up to 2 weeks thereafter. Multiple markers associated with post-stroke recovery, including angiogenesis, oligodendrogenesis, white matter integrity, and neurogenesis, were assessed up to 3 weeks after stroke. Our results showed an impairment in post-stroke vascular remodeling under T2DM conditi...
Source: Cell Research - September 15, 2021 Category: Cytology Authors: Yinghua Jiang Jinrui Han Yadan Li Yinga Wu Ning Liu Samuel X Shi Li Lin Jing Yuan Shusheng Wang Ming-Ming Ning Aaron S Dumont Xiaoying Wang Source Type: research

Injectable biomaterial shuttles for cell therapy in stroke
Brain Res Bull. 2021 Aug 12:S0361-9230(21)00242-2. doi: 10.1016/j.brainresbull.2021.08.002. Online ahead of print.ABSTRACTIschemic stroke (IS) is the leading cause of disability and contributes to a significant socio-economic cost in the western world. Brain repair strategies investigated in the pre-clinical models include the delivery of drug or cell-based therapeutics; which is hindered by the complex anatomy and functional organization of the brain. Biomaterials can be instrumental in alleviating some of these challenges by providing a structural support, localization, immunomodulation and/or modulating cellular cross-t...
Source: Cell Research - August 15, 2021 Category: Cytology Authors: Juhi Samal Tatiana Segura Source Type: research

Reactive astrocytes facilitate vascular repair and remodeling after stroke
Publication date: 27 April 2021Source: Cell Reports, Volume 35, Issue 4Author(s): Michael R. Williamson, Cathleen Joy A. Fuertes, Andrew K. Dunn, Michael R. Drew, Theresa A. Jones
Source: Cell Reports - April 29, 2021 Category: Cytology Source Type: research

Role of DAMPs and of Leukocytes Infiltration in Ischemic Stroke: Insights from Animal Models and Translation to the Human Disease.
Abstract Stroke is a leading cause of death and disability worldwide. Several mechanisms are involved in the pathogenesis of ischemic stroke (IS). The contributory role of the inflammatory and immunity processes was demonstrated both in vitro and in animal models, and was confirmed in humans. IS evokes an immediate inflammatory response that involves complex cellular and molecular mechanisms. All components of the innate and adaptive immunity systems are involved in several steps of the ischemic cascade. In the early phase, inflammatory and immune mechanisms contribute to the brain tissue damage, whereas, in the l...
Source: Cellular and Molecular Neurobiology - September 28, 2020 Category: Cytology Authors: Stanzione R, Forte M, Cotugno M, Bianchi F, Marchitti S, Rubattu S Tags: Cell Mol Neurobiol Source Type: research

A Novel Type of Stem Cells Double-Positive for SSEA-3 and CD45 in Human Peripheral Blood.
Abstract Peripheral blood (PB) contains several types of stem/progenitor cells, including hematopoietic stem and endothelial progenitor cells. We identified a population positive for both the pluripotent surface marker SSEA-3 and leukocyte common antigen CD45 that comprises 0.04% ± 0.003% of the mononuclear cells in human PB. The average size of the SSEA-3(+)/CD45(+) cells was 10.1 ± 0.3 µm and ∼22% were positive for CD105, a mesenchymal marker; ∼85% were positive for CD19, a B cell marker; and ∼94% were positive for HLA-DR, a major histocompatibility complex class II molecule relevant to antigen presenta...
Source: Cell Transplantation - December 31, 2019 Category: Cytology Authors: Sato T, Wakao S, Kushida Y, Tatsumi K, Kitada M, Abe T, Niizuma K, Tominaga T, Kushimoto S, Dezawa M Tags: Cell Transplant Source Type: research

Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier
Ischemic stroke causes blood–brain barrier (BBB) breakdown due to significant damage to the integrity of BBB components. Recent studies have highlighted the importance of pericytes in the repair process of BBB functions triggered by PDGFRβ up-regulation. Here, we show that perlecan, a major heparan sulfate proteoglycan of basement membranes, aids in BBB maintenance and repair through pericyte interactions. Using a transient middle cerebral artery occlusion model, we found larger infarct volumes and more BBB leakage in conditional perlecan (Hspg2)-deficient (Hspg2–/–-TG) mice than in control mice. Con...
Source: Journal of Cell Biology - October 6, 2019 Category: Cytology Authors: Nakamura, K., Ikeuchi, T., Nara, K., Rhodes, C. S., Zhang, P., Chiba, Y., Kazuno, S., Miura, Y., Ago, T., Arikawa-Hirasawa, E., Mukouyama, Y.-s., Yamada, Y. Tags: Disease, Cell Signaling, Migration, Motility, Neuroscience Articles Source Type: research

Aggregation of human mesenchymal stem cells enhances survival and efficacy in stroke treatment
In this study, we report the effects of short-term preconditioning of hMSCs via three-dimensional (3D) aggregation on stroke lesion recovery after intra-arterial (IA) transplantation of 3D aggregate-derived hMSCs (Agg-D hMSCs) in a transient middle cerebral artery occlusion (MCAO) stroke model. Compared with two-dimensional (2D) monolayer culture, Agg-D hMSCs exhibited increased resistance to ischemic stress, secretory function and therapeutic outcome. Short-term preconditioning via 3D aggregation reconfigured hMSC energy metabolism and altered redox cycle, which activated the PI3K/AKT pathway and enhanced resistance to in...
Source: Cytotherapy - September 17, 2019 Category: Cytology Source Type: research

Neural Repair in Stroke.
This article reviews the progress that has been made in the development of cell therapies for the repair of nervous system damage caused by strokes, since the first report on the use of cell transplants in animal models of ischemic brain injury in 1988. At that time neural progenitor cells derived from fetal brain tissue were used as sources of cells to replace specific subsets of neuronal cells that were lost in various regions of the brain following experimentally induced strokes. Since 1988, cells from other sources, such as embryonic stem cells and inducible pluripotent stem cells, have been investigated for their abil...
Source: Cell Transplantation - July 28, 2019 Category: Cytology Authors: Toman NG, Grande AW, Low WC Tags: Cell Transplant Source Type: research

Matrix metalloproteinases and ADAMs in stroke.
Abstract Stroke is a leading cause of death and disability worldwide. However, after years of in-depth research, the pathophysiology of stroke is still not fully understood. Increasing evidence shows that matrix metalloproteinases (MMPs) and "a disintegrin and metalloproteinase" (ADAMs) participate in the neuro-inflammatory cascade that is triggered during stroke but also in recovery phases of the disease. This review covers the involvement of these proteins in brain injury following cerebral ischemia which has been widely studied in recent years, with efforts to modulate this group of proteins in neuroprotective ...
Source: Cellular and Molecular Life Sciences : CMLS - June 4, 2019 Category: Cytology Authors: Montaner J, Ramiro L, Simats A, Hernández-Guillamon M, Delgado P, Bustamante A, Rosell A Tags: Cell Mol Life Sci Source Type: research

Intravenous Grafts of Human Amniotic Fluid-Derived Stem Cells Reduce Behavioral Deficits in Experimental Ischemic Stroke.
This study reports isolation of viable human amniotic fluid-derived stem cells, labeled with multimodal iron oxide nanoparticles, and its effect on focal cerebral ischemia-reperfusion injury in Wistar rats. Middle cerebral artery occlusion of 60 min followed by reperfusion for 1 h, 6 h, and 24 h was employed in the present study to produce ischemia and reperfusion-induced cerebral injury in rats. Tests were employed to assess the functional outcome of the sensorimotor center activity in the brain, through a set of modified neurological severity scores used to assess motor and exploratory capacity 24 h, 14, and 28 days afte...
Source: Cell Transplantation - June 3, 2019 Category: Cytology Authors: Sibov TT, Pavon LF, Cabral FR, Cunha IF, de Oliveira DM, de Souza JG, Marti LC, da Cruz EF, Malheiros JM, Paiva FF, Tannús A, de Oliveira SM, da Costa MDS, Dastoli PA, Mendonça JN, de Toledo SRC, Malheiros SMF, de Paiva Neto MA, Rego NBB, Moron AF, Cava Tags: Cell Transplant Source Type: research