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Procedure: Gastroschisis Repair

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Total 125 results found since Jan 2013.

Central nervous system diseases related to pathological microglial phagocytosis
CNS Neurosci Ther. 2021 Mar 2. doi: 10.1111/cns.13619. Online ahead of print.ABSTRACTMicroglia are important phagocytes of the central nervous system (CNS). They play an important role in protecting the CNS by clearing necrotic tissue and apoptotic cells in many CNS diseases. However, recent studies have found that microglia can phagocytose parts of neurons excessively, such as the neuronal cell body, synapse, or myelin sheaths, before or after the onset of CNS diseases, leading to aggravated injury and impaired tissue repair. Meanwhile, reduced phagocytosis of synapses and myelin results in abnormal circuit connections an...
Source: CNS Neuroscience and Therapeutics - March 2, 2021 Category: Neuroscience Authors: Ke Wang Jiaying Li Yue Zhang Yichen Huang Di Chen Ziyu Shi Amanda D Smith Wei Li Yanqin Gao Source Type: research

Microglial/Macrophage polarization and function in brain injury and repair after stroke
CNS Neurosci Ther. 2021 Mar 1. doi: 10.1111/cns.13620. Online ahead of print.ABSTRACTStroke is a leading cause of disability and mortality, with limited treatment options. After stroke injury, microglia and CNS-resident macrophages are rapidly activated and regulate neuropathological processes to steer the course of functional recovery. To accelerate this recovery, microglia can engulf dying cells and clear irreparably-damaged tissues, thereby creating a microenvironment that is more suitable for the formation of new neural circuitry. In addition, monocyte-derived macrophages cross the compromised blood-brain barrier to in...
Source: CNS Neuroscience and Therapeutics - March 2, 2021 Category: Neuroscience Authors: Junxuan Lyu Di Xie Tarun N Bhatia Rehana K Leak Xiaoming Hu Xiaoyan Jiang Source Type: research

Glial Cell Line-Derived Neurotrophic Factor and Focal Ischemic Stroke.
Abstract Focal ischemic stroke (FIS) is a leading cause of human debilitation and death. Following the onset of a FIS, the brain experiences a series of spatiotemporal changes which are exemplified in different pathological processes. One prominent feature of FIS is the development of reactive astrogliosis and glial scar formation in the peri-infarct region (PIR). During the subacute phase, astrocytes in PIR are activated, referred to as reactive astrocytes (RAs), exhibit changes in morphology (hypotrophy), show an increased proliferation capacity, and altered gene expression profile, a phenomenon known as reac...
Source: Neurochemical Research - February 16, 2021 Category: Neuroscience Authors: Zhang Z, Sun GY, Ding S Tags: Neurochem Res Source Type: research

Neurovascular Unit: A critical role in ischemic stroke.
Abstract Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the area in question, and making a significantly negative impact on human health. Unfortunately, current treatments, that are mainly based on a recanalization of occluded blood vessels, are insufficient or inaccessible to many stroke patients. Recently, the profound influence of the neurovascular unit (NVU) on recanalization and the prognosis of IS have become better understood; in-depth studies of the NVU have also provided novel approaches for IS trea...
Source: CNS Neuroscience and Therapeutics - January 2, 2021 Category: Neuroscience Authors: Wang L, Xiong X, Zhang L, Shen J Tags: CNS Neurosci Ther Source Type: research

Demyelinating processes in aging and stroke in the central nervous system and the prospect of treatment strategy.
Abstract Demyelination occurs in response to brain injury and is observed in many neurodegenerative diseases. Myelin is synthesized from oligodendrocytes in the central nervous system, and oligodendrocyte death-induced demyelination is one of the mechanisms involved in white matter damage after stroke and neurodegeneration. Oligodendrocyte precursor cells (OPCs) exist in the brain of normal adults, and their differentiation into mature oligodendrocytes play a central role in remyelination. Although the differentiation and maturity of OPCs drive endogenous efforts for remyelination, the failure of axons to remyelin...
Source: CNS Neuroscience and Therapeutics - November 19, 2020 Category: Neuroscience Authors: Chen D, Huang Y, Shi Z, Li J, Zhang Y, Wang K, Smith AD, Gong Y, Gao Y Tags: CNS Neurosci Ther Source Type: research

Metabolic determinants of leukocyte pathogenicity in neurological diseases
AbstractNeuroinflammatory and neurodegenerative diseases are characterised by the recruitment of circulating blood ‐borne innate and adaptive immune cells into the central nervous system (CNS). These leukocytes sustain the detrimental response in the CNS by releasing pro‐inflammatory mediators that induce activation of local glial cells, blood‐brain barrier (BBB) dysfunction and neural cell death. However, infiltrating peripheral immune cells could also dampen CNS inflammation and support tissue repair. Recent advances in the field of immunometabolism demonstrate the importance of metabolic reprogramming for the acti...
Source: Journal of Neurochemistry - September 2, 2020 Category: Neuroscience Authors: Marah C. Runtsch, Giovanni Ferrara, Stefano Angiari Tags: REVIEW Source Type: research

Collagen hydrogels loaded with fibroblast growth factor-2 as a bridge to repair brain vessels in organotypic brain slices.
Abstract Vessel damage is a general pathological process in many neurodegenerative disorders, as well as spinal cord injury, stroke, or trauma. Biomaterials can present novel tools to repair and regenerate damaged vessels. The aim of the present study is to test collagen hydrogels loaded with different angiogenic factors to study vessel repair in organotypic brain slice cultures. In the experimental set up I, we made a cut on the organotypic brain slice and tested re-growth of laminin + vessels. In the experimental set up II, we cultured two half brain slices with a gap with a collagen hydrogel placed in betwe...
Source: Experimental Brain Research - August 28, 2020 Category: Neuroscience Authors: Ucar B, Yusufogullari S, Humpel C Tags: Exp Brain Res Source Type: research

Protective Mechanism and Treatment of Neurogenesis in Cerebral Ischemia.
This article reviews several possible mechanisms of stroke and neurogenesis and introduces novel neurogenic agents (fibroblast growth factors, brain-derived neurotrophic factor, purine nucleosides, resveratrol, S-nitrosoglutathione, osteopontin, etc.) as well as other treatments that have shown neuroprotective or neurogenesis-promoting effects. PMID: 32794152 [PubMed - as supplied by publisher]
Source: Neurochemical Research - August 12, 2020 Category: Neuroscience Authors: Li W, Ye A, Ao L, Zhou L, Yan Y, Hu Y, Fang W, Li Y Tags: Neurochem Res Source Type: research

DHA modulates MANF and TREM2 abundance, enhances neurogenesis, reduces infarct size, and improves neurological function after experimental ischemic stroke.
CONCLUSION: MANF and TREM2 protein abundance is robustly increased after MCAo, and DHA treatment potentiated MANF abundance, decreased TREM2 expression, improved neurobehavioral recovery, reduced infarction, and provided enhanced neuroprotection. PMID: 32757264 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - August 4, 2020 Category: Neuroscience Authors: Belayev L, Hong SH, Freitas RS, Menghani H, Marcell SJ, Khoutorova L, Mukherjee PK, Reid MM, Oria RB, Bazan NG Tags: CNS Neurosci Ther Source Type: research

A Critical Role for ISGylation, Ubiquitination and, SUMOylation in Brain Damage: Implications for Neuroprotection.
Abstract Post-translational modification (PTMs) of proteins by ubiquitin and ubiquitin-like modifiers such as interferon-stimulated gene 15 (ISG15) and small ubiquitin-related modifier (SUMO) play a critical role in the regulation of brain pathophysiology. Protein ISGylation is a covalent attachment of ISG15 to its target proteins, which is a unique PTM among other ubiquitin-like modifiers. Although, ISG15 shares sequence homology to ubiquitin, yet the functional significance of protein ISGylation is distinct from ubiquitination and SUMOylation. Further, ISG15 highly conserved among vertebrate species, unlike the ...
Source: Neurochemical Research - June 3, 2020 Category: Neuroscience Authors: Nakka VP, Mohammed AQ Tags: Neurochem Res Source Type: research

Fetal Bovine Serum-More Data
Primary and Stem Cell CultureThis just came across our radar." SUPPLEMENTARY MATERIAL An eye opener in stroke: Mitochondrial dysfunction and stem cell repair in MCAO induced retinal ischemia "We are always delighted when researchers supplement their cell culture media with ourFetal Bovine Serum (FBS).RPE Cells and MSC Culture Retinal pigmented epithelium (RPE, CRL-4000; ATCC) cells were cultured in Dulbecco ’s Modified Eagle Media/F-12 (DMEM/F-12, 11320033; Gibco) containing 10% fetal bovine serum (FBS; FBS001; Neuromics) and 0.01 mg/ml hygromycin B (10687010; Gibco) in incubator (37 °C humidified, with 5% CO2, 95% air)...
Source: Neuromics - January 17, 2020 Category: Neuroscience Tags: adult stem cells FBS Fetal Bovine Serum Human Mesenchymal Stem Cells MSCs Retinal Pigment Epithelial Cells RPES Source Type: news

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