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Specialty: Cardiology
Procedure: Perfusion

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Total 196 results found since Jan 2013.

Update on Neurocritical Care of Stroke
AbstractPurpose of ReviewThis review will highlight the recent advancements in acute ischemic stroke diagnosis and treatment, with special attention to new features and recommendations of stroke care in the neurocritical care unit.Recent FindingsNew studies suggest that pre-hospital treatment of stroke with mobile stroke units and telestroke technology may lead to earlier stroke therapy with intravenous tissue plasminogen activator (tPA), and recent studies show tPA can be given in previously contraindicated situations. More rapid automated CT perfusion and angiography may demonstrate a vascular penumbra for neuroendovascu...
Source: Current Cardiology Reports - June 23, 2017 Category: Cardiology Source Type: research

Predictive utility of stress tests in the detection of asymptomatic coronary artery disease in atherosclerotic stroke patients
CONCLUSION: Myocardial ischemia and CV events were infrequent and both strongly associated with ECG signs of necrosis, suggesting a low yield of stress tests and the potential for a more straightforward algorithm in the choice of patients eligible to coronary angiogram or other coronary imaging in post-stroke setting.PMID:37567133 | DOI:10.1016/j.jstrokecerebrovasdis.2023.107290
Source: Atherosclerosis - August 11, 2023 Category: Cardiology Authors: Jean-S ébastien Liegey Sami Fawaz Claire Ducos Yann Pucheu Romain Boulestreau Igor Sibon Thierry Couffinhal Source Type: research

CEACAM1 Inhibits MMP-9-Mediated Blood-Brain-Barrier Breakdown in a Mouse Model for Ischemic Stroke.
Conclusions: CEACAM1 controls MMP-9 secretion by neutrophils in postischemic inflammation at the BBB after stroke. We propose CEACAM1 as an important inhibitory regulator of neutrophil-mediated tissue damage and BBB breakdown in focal cerebral ischemia. PMID: 23780386 [PubMed - as supplied by publisher]
Source: Circulation Research - June 18, 2013 Category: Cardiology Authors: Ludewig P, Sedlacik J, Gelderblom M, Bernreuther C, Korkusuz Y, Wagener C, Gerloff C, Fiehler J, Magnus T, Horst AK Tags: Circ Res Source Type: research

Imaging in acute stroke.
Authors: Eswaradass P, Appireddy R, Evans J, Tham C, Dey S, Najm M, Menon BK Abstract INTRODUCTION: Stroke is the third leading cause of death and disability in Canada. In the hyperacute stroke setting, the treating physician must make a time critical decision on the treatment of each patient. Recent advances in imaging help the treating physician identify the subgroup of patients eligible for acute treatment of ischaemic stroke. AREAS COVERED: In this review we will discuss Non-Contrast Computed Tomography (NCCT), CT-Angiography (CTA), and CT-Perfusion (CTP) in assessment of patients with acute ischaemic strok...
Source: Expert Review of Cardiovascular Therapy - June 3, 2016 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Neuroendovascular Surgery for the Treatment of Ischemic Stroke
This review discusses modern therapeutic interventions for acute ischemic stroke with a focus on endovascular therapy. In 2015, the American Heart Association made major changes to the guidelines for the endovascular treatment of acute ischemic stroke. The Class IA indications for endovascular therapy of stroke patients include symptom onset within 6 h, proven large vessel occlusion of an artery in the anterior circulation, and the use of a stent retriever as part of the mechanical thrombectomy. Advanced perfusion imaging helps identify patients with a low ratio of ischemic core to salvageable penumbra. Equally important...
Source: Cardiology in Review - October 7, 2017 Category: Cardiology Tags: Review Articles Source Type: research

Delayed retinal vein recovery responses indicate both non-adaptation to stress as well as increased risk for stroke: the SABPA study.
CONCLUSIONS: In response to low norepinephrine, a reflex increase in SAM activity occurred, enhancing arterial vasoconstriction and hypo-perfusion. Concomitant HPA dysregulation attenuated retinal vein vasoactivity and tone, reflecting delayed vein recovery responses and non-adaptation to stress. These constrained vein recovery responses are indicative of increased chronic stress and stroke risk. PMID: 33104153 [PubMed - as supplied by publisher]
Source: Cardiovascular Journal of Africa - October 26, 2020 Category: Cardiology Authors: Malan L, Hamer M, von Känel R, Kotliar K, van Wyk RD, Lambert GW, Vilser W, Ziemssen T, Schlaich MP, Smith W, Magnusson M, Wentzel A, Myburgh CE, Steyn HS, Malan NT Tags: Cardiovasc J Afr Source Type: research

Quantitative Collateral Assessment on CTP in the Prediction of Stroke Etiology
CONCLUSIONS: Patients with large-artery atherosclerosis had a more adequate collateral perfusion supply with the new quantitative collateral assessment. The new quantitative collateral measurement might contribute to the prediction of stroke etiology in the acute clinical scenario for patients with acute ischemic stroke.PMID:35738675 | DOI:10.3174/ajnr.A7549
Source: Atherosclerosis - June 23, 2022 Category: Cardiology Authors: F Shi Q Zeng X Gong W Zhong Z Chen S Yan M Lou Source Type: research

Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke
In this study, we tested the hypothesis that GLP-1 mediates neuroprotection induced by RIC and investigated the effect of GLP-1R activation on cerebral blood vessels, as a potential mechanism of GLP-1-induced protection against ischaemic stroke. A rat model of ischaemic stroke (90 min of  middle cerebral artery occlusion followed by 24-h reperfusion) was used. RIC was induced by 4 cycles of 5 min left hind limb ischaemia interleaved with 5-min reperfusion periods. RIC markedly (by ~ 80%) reduced the cerebral infarct size and improved the neurological score. The neuroprotection established by RIC was abolished by syst...
Source: Basic Research in Cardiology - May 3, 2021 Category: Cardiology Source Type: research

Hypoperfusion Intensity Ratio is Associated with Stroke Mechanism in Patients Undergoing Mechanical Thrombectomy
CONCLUSIONS: Large artery atherosclerosis was independently associated with favorable HIR in patients undergoing mechanical thrombectomy. While favorable HIR was associated with smaller pre-treatment core infarcts, reflecting more robust collaterals, it was not associated with good clinical outcome.PMID:35550982 | DOI:10.1016/j.jstrokecerebrovasdis.2022.106539
Source: Atherosclerosis - May 13, 2022 Category: Cardiology Authors: Ahmad A Ballout Richard B Libman Julia R Schneider Marc S Ayoub Jason J Wang Athos Patsalides Jeffrey M Katz Source Type: research

Impact of Co-morbidity on the Risk of First-Time Myocardial Infarction, Stroke, or Death After Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging
In conclusion, independently of co-morbidity level, an abnormal SPECT MPI scan was associated with an increased 10-year risk of myocardial infarction and all-cause death but not stroke.
Source: The American Journal of Cardiology - June 9, 2014 Category: Cardiology Authors: Astrid Blicher Schelde, Morten Schmidt, Morten Madsen, Karin Lottrup Petersen, Søren Steen Nielsen, Jørgen Frøkiær, Henrik Toft Sørensen, Christian Fynbo Christiansen Tags: Coronary Artery Disease Source Type: research

Three Dimensional-Arterial Spin Labeling Evaluation of Improved Cerebral Perfusion After Limb Remote Ischemic Preconditioning in a Rat Model of Focal Ischemic Stroke
CONCLUSION: Three dimensional (3D) ASL can be used to evaluate LRP to improve stroke perfusion, and its protective effect may be closely related to LRP-induced vascular regeneration.PMID:35847828 | PMC:PMC9280338 | DOI:10.3389/fnana.2022.893953
Source: Atherosclerosis - July 18, 2022 Category: Cardiology Authors: Tianxiu Zheng Xiaolan Lai Jiaojiao Lu Qiuyan Chen Dingtai Wei Source Type: research

Predictive factors for clinical outcomes in Filipino patients with watershed infarction: A single center study
CONCLUSION: Clinical outcomes between watershed infarcts and acute ischemic strokes were similar. Hemodynamic compromise in the setting of severe stenosis is the underlying mechanism for both types of watershed strokes thus, the goal of treatment is to maintain adequate perfusion. High baseline NIHSS score, increased age, female gender and underlying malignancy were all poor predictors of clinical outcomes in patients with watershed strokes.PMID:36908808 | PMC:PMC9995929 | DOI:10.1016/j.ensci.2023.100450
Source: Atherosclerosis - March 13, 2023 Category: Cardiology Authors: Marian Irene C Escasura Jose C Navarro Stroke Data Bank Investigators Source Type: research

Differences in symmetrical low-frequency oscillations among healthy subjects, and those with stroke or peripheral arterial disease
Conclusions: LFOs can serve as vascular perfusion biomarkers to differentiate types and degrees of vascular lesions. Therefore, LFOs have the potential to provide valuable patient information to assist researchers and clinicians in identifying specific peripheral circulatory damage subgroups.PMID:37484434 | PMC:PMC10361110 | DOI:10.1016/j.heliyon.2023.e17015
Source: Atherosclerosis - July 24, 2023 Category: Cardiology Authors: Yunfei Ma Kexin Luo Peng Ding Shimin Yin Xiaoli Li Yingwei Li Source Type: research