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Specialty: General Medicine
Therapy: Statin Therapy

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Total 204 results found since Jan 2013.

Regional Deprivation, Stroke Incidence, and Stroke Care
CONCLUSION: These findings document a relationship between regional deprivation and the occurrence of acute ischemic stroke. Poorer GIMD 2010 scores were associated with worse care outcomes in a number of variables, but the absolute differences were small.PMID:34304754 | DOI:10.3238/arztebl.m2021.0149
Source: Deutsches Arzteblatt International - July 26, 2021 Category: General Medicine Authors: Armin J Grau Sieghard Dienlin Dirk Bartig Werner Maier Florian Buggle Heiko Becher Source Type: research

Cerebral Amyloid Angiopathy in Stroke Medicine.
CONCLUSION: In patients with CAA, arterial hypertension should be tightly controlled. On the other hand, caution should be exercised in prescribing oral anticoagulants or platelet aggregation inhibitors for patients with CAA, or statins for patients who have already sustained a lobar ICH. PMID: 28179050 [PubMed - in process]
Source: Deutsches Arzteblatt International - February 11, 2017 Category: Journals (General) Tags: Dtsch Arztebl Int Source Type: research

The effect of atorvastatin on the common carotid artery intima-media thickness in patients with ischemic stroke.
Authors: Khazaei M, Khosravi M, Mazaheri S, Mazdeh M, Ghiasian M, Taheri M, Ghafouri-Fard S Abstract Occlusion of the initial segment of internal carotid artery is the most common reason for vascular events in the brain. The purpose of this study was to investigate the effect of one-year treatment with atorvastatin on intima-media thickness (IMT) of carotid arteries as a measure of atherosclerosis in stroke patients. In this prospective interventional study, 44 patients with ischemic stroke were investigated. Patients were treated with atorvastatin 40 mg once a day for one year. IMT of carotid arteries was measured...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Case management for blood pressure and lipid level control after minor stroke: PREVENTION randomized controlled trial.
Abstract BACKGROUND:Optimization of systolic blood pressure and lipid levels are essential for secondary prevention after ischemic stroke, but there are substantial gaps in care, which could be addressed by nurse- or pharmacist-led care. We compared 2 types of case management (active prescribing by pharmacists or nurse-led screening and feedback to primary care physicians) in addition to usual care. METHODS:We performed a prospective randomized controlled trial involving adults with recent minor ischemic stroke or transient ischemic attack whose systolic blood pressure or lipid levels were above guideline targets....
Source: cmaj - April 14, 2014 Category: Journals (General) Authors: McAlister FA, Majumdar SR, Padwal RS, Fradette M, Thompson A, Buck B, Dean N, Bakal JA, Tsuyuki R, Grover S, Shuaib A Tags: CMAJ Source Type: research

Association between statin use and ischemic stroke or major hemorrhage in patients taking dabigatran for atrial fibrillation.
Authors: Antoniou T, Macdonald EM, Yao Z, Hollands S, Gomes T, Tadrous M, Mamdani MM, Juurlink DN, Canadian Drug Safety and Effectiveness Research Network Abstract BACKGROUND: Dabigatran etexilate is a prodrug whose absorption is opposed by intestinal P-glycoprotein and which is converted by carboxylesterase to its active form, dabigatran. Unlike other statins, simvastatin and lovastatin are potent inhibitors of P-glycoprotein and carboxylesterase, and might either increase the risk of hemorrhage with dabigatran etexilate or decrease its effectiveness. METHODS: We conducted 2 population-based, nested case-contr...
Source: Canadian Medical Association Journal - March 3, 2017 Category: Journals (General) Tags: CMAJ Source Type: research

Cholesterol lowering and stroke: no longer room for pleiotropic effects of statins – confirmation from PCSK9 inhibitor studies
The relationship between cholesterol levels and stroke has been much less clear than between cholesterol levels and coronary heart disease. This is likely mostly due to the inadequate power of older studies and the low intensity of cholesterol-lowering interventions at that time available. Because a reduction in stroke has been, conversely, clearly observed in trials with statins, for long “pleiotropic” effects of such drugs, unrelated to cholesterol lowering, have been invoked. In a previous analysis of all randomized trials of cholesterol-lowering treatments reporting on stroke we had, however, reached the conclusion...
Source: The American Journal of Medicine - July 10, 2019 Category: General Medicine Authors: Tanya Salvatore, Riccardo Morganti, Roberto Marchioli, Raffaele De Caterina Tags: Clinical Research Study Source Type: research

Identifying factors explaining practice variation in secondary stroke prevention in primary care: a cohort study based on all patients with ischaemic stroke in the Stockholm region
Conclusions A high practice variation for dispensation of all secondary preventive drugs was observed. Patient and PCC level factors indicating good continuity of care and high level of general practitioner education were associated with higher use of statins. Findings are of importance to policymakers as well as individual providers of care, and more research and actions are needed to minimise inequality in healthcare.
Source: BMJ Open - November 21, 2022 Category: General Medicine Authors: Wolf, M., Hasselström, J. K., Carlsson, A., Euler, M. v., Hasselström, J. Tags: Open access, Neurology Source Type: research

Statins and stroke
Publication date: Available online 14 March 2016 Source:Apollo Medicine Author(s): Dinesh M. Chaudhari, Pushpendra Nath Renjen, Mahir Memon Stroke is a heterogeneous condition with a number of possible etiologies. Patients with different underlying stroke pathophysiologies may variably respond to specific preventive treatment strategies. Statin outcome trials in subjects with established coronary artery disease, hypertension, diabetes, or at high vascular risk have shown a consistent 17–21% relative reduction in the risk of incident stroke. The benefits observed with statins appear to be greater than what might be e...
Source: Apollo Medicine - March 14, 2016 Category: Journals (General) Source Type: research

154: a pharmacoeconomic evaluation to make decision: is the use of simvastatin 10 mg as an otc medication cost-effective for the primary prevention of stroke amongst women in iran?
Conclusion: In Iran no threshold has been determined but the results were compared with the threshold that WHO recommended (GDP per capita for Iran is $5442.9 for 2014 by World Bank). Considering this threshold, the evaluated intervention could be considered cost-effective.
Source: BMJ Open - February 7, 2017 Category: Journals (General) Authors: Amirsadri, M., Dorri, N. Tags: Open access Oral Source Type: research

Stopping Statins After Stroke May Raise Risk of Another
WEDNESDAY, Aug. 2, 2017 -- Stroke survivors who stop taking cholesterol-lowering statins are at increased risk for another stroke, a new study finds. Researchers studied more than 45,000 ischemic stroke survivors who were prescribed a statin within...
Source: Drugs.com - Daily MedNews - August 2, 2017 Category: General Medicine Source Type: news

Less Than Half of U.S. Stroke Patients Get Rx for Statins
WEDNESDAY, Aug. 2, 2017 -- Fewer than half of U.S. stroke survivors are prescribed cholesterol-lowering statins, a new study finds. Statins are recommended for patients who have had an ischemic stroke or mini-stroke (transient ischemic attack) to...
Source: Drugs.com - Daily MedNews - August 2, 2017 Category: General Medicine Source Type: news