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Specialty: General Medicine
Therapy: Thrombolytic Therapy

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Total 52 results found since Jan 2013.

Telemedicine remote controlled stroke evaluation and treatment, the experience of radiographers, paramedics and junior doctors in a novel rural stroke management team
In the case of ischemic stroke, access to a Computed Tomography (CT) scanner and the start of thrombolytic therapy immediately is imperative. Transport to the nearest hospital from the remote, rural area of Ha...
Source: BMC Health Services Research - June 5, 2021 Category: General Medicine Authors: Elin Kjelle and Aud Mette Myklebust Tags: Research Source Type: research

Intravenous Thrombolytic Therapy for Treatment of Acute Ischemic Stroke in Patients Taking NOACs
Intravenous thrombolytic therapy with recombinant tissue plasminogen activator (alteplase) is the cornerstone of acute ischemic stroke reperfusion therapy and is associated with significant improvements in outcomes. Historically, a number of exclusion criteria for use of alteplase had been in place, but over the past 20 years, some of these have been eliminated (eg, age>80 years, seizures at stroke onset) or have become less stringent (eg, exclusion criteria may not strictly apply to recent vitamin K antagonist treatment if the patient has an international normalized ratio<1.7, and treatment may be administered in an...
Source: JAMA - February 22, 2022 Category: General Medicine Source Type: research

Evaluation of the quantitative performance of non-enhanced dual-energy CT X-map in detecting acute ischemic brain stroke: A model observer study using computer simulation
Acute ischemic stroke (AIS) is a critical brain disease that is prevalent in developed countries [1]. Rapid and accurate diagnosis of AIS is highly desirable before implementing thrombolytic therapy or mechanical thrombectomy, which helps improve the prognosis of patients with ischemic stroke [2 –4].
Source: Physica Medica: European Journal of Medical Physics - November 10, 2022 Category: General Medicine Authors: Toshihide Itoh, Kyo Noguchi Tags: Original paper Source Type: research

Stroke Rounds: Uric Acid Post tPA (CME/CE)
SAN DIEGO (MedPage Today) -- Despite missing its primary endpoint, a randomized trial suggested that giving uric acid after intravenous thrombolytic therapy to patients with acute ischemic stroke might help improve outcomes.
Source: MedPage Today Meeting Coverage - February 13, 2014 Category: Journals (General) Source Type: news

Efforts to reduce the door-to-needle time of thrombolysis in acute ischemic stroke: Video-assisted therapeutic risk communication
Conclusion A thrombolysis program with video-assisted therapeutic risk communication decreased DTN time and increased the treatment rate of patients with AIS.
Source: Journal of the Formosan Medical Association - December 19, 2014 Category: Journals (General) Source Type: research

Long-term Outcomes After Thrombolytic Therapy for Acute Ischemic Stroke
The role of intravenous thrombolytic therapy in the management of acute ischemic stroke is well established, and faster administration of intravenous tissue plasminogen activator (tPA) has been associated with better short-term outcomes in clinical practice.
Source: JAMA - June 2, 2020 Category: General Medicine Source Type: research

Ipsilateral Vocal Cord Paralysis After Acute Anterior Ischemic Stroke
CONCLUSION: Our case is a rare case of transient ipsilateral vocal cord paralysis associated with anterior unilateral cerebral ischemia. The paralysis resolved with improvement of the cerebral ischemic penumbra.PMID:33635769 | DOI:10.7812/TPP/20.104
Source: The Permanente journal - February 26, 2021 Category: General Medicine Authors: Khalid Sawalha Ahmed Abd Elazim Omar Hussein Source Type: research

Hjerneslag i Norge 2015 –16 – behandling og resultater.
Hjerneslag i Norge 2015–16 – behandling og resultater. Tidsskr Nor Laegeforen. 2020 Feb 04;140(2): Authors: Varmdal T, Indredavik B, Phan A, Fjærtoft H Abstract BACKGROUND: Treatment of stroke in Norway is decentralised; patients with stroke are treated at 50 different hospitals. We have surveyed the treatment of stroke in these hospitals and collated this with data from the Norwegian Stroke Registry. We wished to investigate whether there was any variation in treatment interventions and treatment outcomes between university hospitals and local hospitals. MATERIAL AND METHOD: A questionnaire...
Source: Tidsskrift for den Norske Laegeforening - February 3, 2020 Category: General Medicine Authors: Varmdal T, Indredavik B, Phan A, Fjærtoft H Tags: Tidsskr Nor Laegeforen Source Type: research

Thrombolytic therapy for pulmonary embolism.
CONCLUSIONS: There is low quality evidence that thrombolytics reduce death following acute pulmonary embolism compared with heparin. Furthermore, thrombolytic therapies included in the review were heterogeneous. Thrombolytic therapy may be helpful in reducing the recurrence of pulmonary emboli but may cause more major and minor haemorrhagic events and stroke. More high quality double blind RCTs assessing safety and cost-effectiveness are required. PMID: 26419832 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - September 30, 2015 Category: Journals (General) Authors: Hao Q, Dong BR, Yue J, Wu T, Liu GJ Tags: Cochrane Database Syst Rev Source Type: research

Cortical hemiballism: A case of hemiballismus associated with parietal lobe infarct
Conclusion: Lesions affecting various areas outside the STN can cause hemiballism and usually carries a good prognosis with spontaneous resolution. Acute thrombolytic therapy may be considered on an individual basis. Treatment with antipsychotics can be useful for severe and recurring symptoms.
Source: North American Journal of Medical Sciences - December 30, 2015 Category: Journals (General) Authors: Pragya ShresthaJanak AdhikariDilli PoudelRanjan PathakParas Karmacharya Source Type: research

Thrombolytic therapy for pulmonary embolism
CONCLUSIONS: Low-certainty evidence suggests that thrombolytics may reduce death following acute pulmonary embolism compared with heparin (the effectiveness was mainly driven by one trial with massive PE). Thrombolytic therapy may be helpful in reducing the recurrence of pulmonary emboli but may cause more major and minor haemorrhagic events, including haemorrhagic stroke. More studies of high methodological quality are needed to assess safety and cost effectiveness of thrombolytic therapy for people with pulmonary embolism.PMID:33857326 | DOI:10.1002/14651858.CD004437.pub6
Source: Cochrane Database of Systematic Reviews - April 15, 2021 Category: General Medicine Authors: Zhiliang Zuo Jirong Yue Bi Rong Dong Taixiang Wu Guan J Liu Qiukui Hao Source Type: research

The Reply
Intracranial bleeding with thrombolytic therapy in elderly patients with pulmonary embolism is far less frequent than death if unstable and thrombolytic therapy is withheld (42.6% mortality if untreated, aged 61-70, and no comorbid conditions vs 9.3% mortality with thrombolytic therapy; 47.0% mortality with comorbid conditions if untreated vs 21.6% if treated). In patients>65 years or with kidney disease, intracranial hemorrhage occurred in 1.4% with thrombolytic therapy. Intracranial hemorrhage with thrombolytic therapy in elderly patients with acute myocardial infarction also occurred in 1.4%. With ≥ 5 risk factors for...
Source: The American Journal of Medicine - October 22, 2013 Category: Journals (General) Authors: Paul D. Stein, Fadi Matta Tags: Letters Source Type: research