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Specialty: Hematology
Procedure: Perfusion

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Total 41 results found since Jan 2013.

Lack of secondary microthrombosis after thrombin-induced stroke in mice and non-human primates.
CONCLUSIONS: Our data demonstrates that secondary microthrombosis does not occur after thrombin-induced stroke. In view of that, the pathophysiological roles of hematologic players promoting or protecting from secondary microthrombosis (such as Factor XII, von Willebrand Factor, T-cells…) deserve to be reevaluated in non-TMVO stroke models. This article is protected by copyright. All rights reserved. PMID: 24354644 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - December 16, 2013 Category: Hematology Authors: Gauberti M, de Lizarrondo SM, Orset C, Vivien D Tags: J Thromb Haemost Source Type: research

Hematocrit and Stroke: A Forgotten and Neglected Link?
Semin Thromb Hemost DOI: 10.1055/s-0037-1602663Stroke is considered among the most common causes of mortality and disability, leading to dramatic socioeconomic consequences. From a pathophysiologic perspective, enhanced blood viscosity due to increased hematocrit might be associated with stroke through impaired cerebral blood perfusion. This association has remained rather neglected during previous decades, but newly emerged as an epicenter of scientific interest due to the unexpected elevation of stroke rates with sodium-glucose cotransporter-2 inhibitors, a new class of hypoglycemic drugs with otherwise dramatic cardiova...
Source: Seminars in Thrombosis and Hemostasis - June 13, 2017 Category: Hematology Authors: Stavropoulos, Konstantinos Imprialos, Konstantinos P. Bouloukou, Sofia Boutari, Chrysoula Doumas, Michael Tags: Review Article Source Type: research

Dynamic perfusion analysis in acute ischemic stroke: A comparative study of two different softwares
CONCLUSIONS: Although the absolute values have a certain degree of variation, both software programs have good agreement with each other.PMID:34420946 | DOI:10.3233/CH-219106
Source: Clinical Hemorheology and Microcirculation - August 23, 2021 Category: Hematology Authors: Cornelius Krusche Carolina Rio Bartulos Mazen Abu-Mugheisib Michael Haimerl Philipp Wiggermann Source Type: research

ADAMTS13 controls vascular remodeling by modifying VWF reactivity during stroke recovery
Angiogenic response is essential for ischemic brain repair. The von Willebrand factor (VWF)–cleaving protease disintegrin and metalloprotease with thrombospondin type I motif, member 13 (ADAMTS13) is required for endothelial tube formation in vitro, but there is currently no in vivo evidence supporting a function of ADAMTS13 in angiogenesis. Here we show that mice deficient in ADAMTS13 exhibited reduced neovascularization, brain capillary perfusion, pericyte and smooth muscle cell coverage on microvessels, expression of the tight junction and basement membrane proteins, and accelerated blood-brain barrier (BBB) break...
Source: Blood - July 6, 2017 Category: Hematology Authors: Xu, H., Cao, Y., Yang, X., Cai, P., Kang, L., Zhu, X., Luo, H., Lu, L., Wei, L., Bai, X., Zhu, Y., Zhao, B.-Q., Fan, W. Tags: Plenary Papers, Thrombosis and Hemostasis, Vascular Biology Source Type: research

Contrast-enhanced ultrasound perfusion patterns and serum lipid signatures of vulnerable carotid artery plaque in predicting stroke: A cohort study of carotid stenosis in Chinese patients.
CONCLUSION: A high level of CEUS perfusion and increased serum FFA levels are indicative of vulnerable carotid plaques, which may be useful for the prediction of stroke in patients with carotid artery disease. PMID: 32039838 [PubMed - as supplied by publisher]
Source: Clinical Hemorheology and Microcirculation - February 6, 2020 Category: Hematology Authors: Huang Y, Liu Q, Xu J, Zhu W, Jiang J, Tang L, Chen M Tags: Clin Hemorheol Microcirc Source Type: research

Thrombus composition and thrombolysis resistance in stroke
Res Pract Thromb Haemost. 2023 May 16;7(4):100178. doi: 10.1016/j.rpth.2023.100178. eCollection 2023 May.ABSTRACTA State of the Art lecture titled "Thrombus Composition and Thrombolysis Resistance in Stroke" was presented at the ISTH Congress in 2022. Intravenous thrombolysis (IVT) remains the only pharmacologic option to re-establish cerebral perfusion at the acute phase of ischemic stroke. IVT is based on the administration of recombinant tissue plasminogen activator with the objective of dissolving fibrin, the major fibrillar protein component of thrombi. Almost 30 years on from its introduction, although the clinical b...
Source: Thrombosis and Haemostasis - August 4, 2023 Category: Hematology Authors: Benoit Ho-Tin-No é Jean-Philippe Desilles Mikael Mazighi Source Type: research

Association of antithrombotic medications and composition of thrombi retrieved by mechanical thrombectomy in acute ischemic stroke
Timely restoration of blood perfusion through thrombolysis and/or mechanical thrombectomy (MT) is an important step in salvaging ischemic brain in stroke patients. MT has opened an avenue for histological evaluation of thrombi and over the last couple of years our knowledge on the thromboembolus histological and mechanical properties and effects of these properties on the success of MT has grown significantly [1,2]. Two major classes of antithrombotic therapies, including antiplatelet and anticoagulant drugs, have been used for both management and prevention of stroke.
Source: Thrombosis Research - September 26, 2021 Category: Hematology Authors: Mehdi Abbasi, Oana Madalina Mereuta, Sean F. Fitzgerald, Daying Dai, Alejandro A. Rabinstein, Ramanathan Kadirvel, David F. Kallmes, Waleed Brinjikji Tags: Letter to the Editors-in-Chief Source Type: research