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Specialty: Nuclear Medicine

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Total 204 results found since Jan 2013.

Development of a Two-layer Dynamic Cardiac Phantom with a Double Pump.
CONCLUSION: In our dynamic cardiac phantom, different movements could be induced in the myocardial wall by freely changing the stroke ratio. These results suggest that the use of this phantom can realize technical evaluation that presumes various clinical conditions. PMID: 26769601 [PubMed - as supplied by publisher]
Source: Journal of Nuclear Medicine Technology - January 17, 2016 Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research

Robust supervised clustering analysis of 18F DPA-714 dynamic clinical PET data
Conclusion: The modified SVCA method presented here can be used with [18F]DPA-714 dynamic PET data to detect brain tissue with neuroinflammation caused by stroke. In this study where the subjects were supposedly devoid of neuroinflammation in the cerebellum, the reference curves found by the proposed approach were very similar to those of the cerebellum while not being based on any anatomical prior. Future work should continue to optimize the method and to investigate the generalizability of the current finding to other clinical cases where neuroinflammation can occur significantly in the cerebellum. Research Support: NICA...
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Love, S., Jaouen, V., Annan, M., Cottier, J.-P., Vercouillie, J., Guilloteau, D., Santiago-Ribeiro, M.-J., Tauber, C. Tags: Advanced Image Processing and Analysis Source Type: research

Use of cerebrospinal fluid flow rates measured by phase-contrast MR to differentiate normal pressure hydrocephalus from involutional brain changes
Conclusion The mean CSF flow rate may be useful in the diagnosis and differential diagnosis, and the prediction of the potential benefits of surgical intervention for patients considered to have NPH.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - April 19, 2016 Category: Nuclear Medicine Source Type: research

Clinical implications for Translocator Protein (TSPO) imaging using 123ICLINDE SPECT: A feasible approach
Conclusions The preliminary results imply that [123I]CLINDE-SPECT is a feasible approach for TSPO imaging in neurological disorders associated with microglial activation and/or increased TSPO expression. The development of methods that do not need arterial blood sampling for quantification of TSPO will be important to ease implementation in a daily clinical setting. Further clinical studies are needed to determine the precise role of TSPO imaging in predicting clinical outcome and treatment response.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Thomsen, G., Jensen, P., Feng, L., Knudsen, L., Knudsen, G., Pinborg, L. Tags: Neurosciences/Neurology. Miscellaneous Source Type: research

Myocardial Energetics in AL and ATTR Cardiac Amyloidosis: A C-11 Acetate PET/CT Study
Conclusions: These results suggest that myocardial structure and energy utilization patterns differ between patients with AL-CMP and ATTR-CMP. Patients with AL-CMP have much lower myocardial mass and lower energy efficiency compared to patients with ATTR-CMP, suggesting better myocardial metabolic adaptation in ATTR-CMP. These findings if confirmed in a larger cohort suggest a role for novel therapeutics to manipulate substrate utilization in AL-CMP. AL-CMP(N=20)ATTR-CMP(N=3)P-ValueAge63 ± 6.380 ± 0.8<0.0001Rate Pressure Product, systolic blood pressure X heart rate, (mm Hg bpm)9228 ± 13608318 &plus...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: El-Sady, M. S., Kijewski, M., Jacob, S., Bravo, P., Dubey, S., Nodoushani, A., Belanger, A., Park, M.-A., Falk, R., Di Carli, M., Dorbala, S. Tags: Cardiac Metabolism, Viability, and Innervation Source Type: research

Plaque Inflammation Imaging in Severe Carotid Stenosis and Recurrent Cerebral Ischemia.
Authors: Sharma VK, Paliwal PR, Sinha AK Abstract Strong relationship exists between the severity of carotid stenosis and early stroke-risk. Inflammation is believed to be an important event for atherosclerotic plaque destabilisation and subsequent thrombo-embolism. 18-Fluoro-deoxyglucose Positron Emission Tomography ((18)F-FDG) can image atherosclerotic inflammation, providing information about plaque biology, which may serve as a useful biomarker for the assessment of early stroke-risk. PMID: 25857415 [PubMed - as supplied by publisher]
Source: Journal of Nuclear Medicine Technology - June 4, 2015 Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research

18FFLT - A new stem cell label for in vivo tracking with positron emission tomography
Conclusions In conclusion, [18F]FLT labeling of sheep MSCs is feasible. 60min incubation time with the tracer does not perturb the biologic and functional properties of adult sheep MSCs in vitro. This labeling method and optimization strategy has led to pilot studies investigating the biodistribution of [18F]FLT-labeled MSCs in mice using small-animal PET/MRI. Future studies will also determine whether [18F]FLT-labeled MSCs can be tracked over time in a large animal model to assess the therapeutic potential of MSCs after stroke.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: GroAYmann, U., Zeisig, V., McLeod, D., Dreyer, A., Patt, M., Schildan, A., Sabri, O., Boltze, J., Barthel, H. Tags: SPECIAL MTA: Preclinical Probes for Neuroimaging Posters Source Type: research

Automatic calculation of myocardial external efficiency using a single 11C-acetate PET/CT scan: a dual-center validation
Conclusions Myocardial efficiency can be calculated automatically using only a single 11C-acetate PET scan. This facilitates clinical applicability and provides unbiased access to a sensitive marker of cardiac dysfunction.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Harms, H. J., Hansson, N., Kero, T., A-rndahl, L., Kim, Y., Frokiaer, J., Wiggers, H., Flachskampf, F., Tolbod, L., Sorensen, J. Tags: MTA II: Cardiovascular Clinical Science Posters Source Type: research

Automatic Extraction of Myocardial Mass and Volume Using Parametric Images from Dynamic Nongated PET
Conclusion: LV mass and volume are accurately and automatically generated from dynamic 11C-acetate PET without electrocardiogram gating. This method can be incorporated in a standard routine without any additional workload and can, in theory, be extended to other PET tracers.
Source: Journal of Nuclear Medicine - August 31, 2016 Category: Nuclear Medicine Authors: Harms, H. J., Stubkjaer Hansson, N. H., Tolbod, L. P., Kim, W. Y., Jakobsen, S., Bouchelouche, K., Wiggers, H., Frokiaer, J., Sorensen, J. Tags: Clinical Investigations Source Type: research

18F-FNDP for PET Imaging of Soluble Epoxide Hydrolase
Conclusion: 18F-FNDP can be synthesized in suitable radiochemical yield and high specific radioactivity and purity. In vivo imaging experiments demonstrated that 18F-FNDP targeted sEH in murine and nonhuman primate brain specifically. 18F-FNDP is a promising PET radiotracer likely to be useful for understanding the role of sEH in a variety of conditions affecting the central nervous system.
Source: Journal of Nuclear Medicine - October 31, 2016 Category: Nuclear Medicine Authors: Horti, A. G., Wang, Y., Minn, I., Lan, X., Wang, J., Koehler, R. C., Alkayed, N. J., Dannals, R. F., Pomper, M. G. Tags: Basic Science Investigations Source Type: research

Cardiac MR-assessed hemodynamic changes in pulmonary arterial hypertension and their relation to pulmonary artery pressure
Conclusion MR-derived ventricular mass index, right ventricular mass, and right ventricular ejection fraction had the strongest relation with the pulmonary artery pressure, and hence they could be reliable parameters on monitoring patients with pulmonary arterial hypertension.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - December 20, 2016 Category: Nuclear Medicine Source Type: research

18F-NaF PET Demonstrating Unusual Focal Tracer Activity in the Brain
Abstract: A 60-year-old man with enlarged prostate, hypertension, and diabetes was referred for 18F-NaF PET/CT to evaluate possible metastatic lesions. The patient appeared asymptomatic on the day of the study, without any signs indicating stroke. Patient also had no known history of malignancy or cerebrovascular disease. He had mild elevation of the prostate-specific antigen level, and biopsy of his prostate was not performed. Patient had long-standing history of chronic back pain and abdominal pain. The PET bone scan demonstrated a large area of very intense tracer uptake in the brain. A subsequent brain MRI revealed pri...
Source: Clinical Nuclear Medicine - January 10, 2017 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

All That Glitters Is not Gold: Peals and Pitfalls in I-131 Scans for Differentiated Thyroid Cancer
Conclusion: We review thyroid gland physiology and describe a systemic overview of potential false positive and false negative lack of uptake of radioiodine in the whole body along with illustrations and cases. By understanding the physiology and characteristics of radioiodine uptake and correlating with anatomical imaging, biochemical data, and clinical findings, physicians can be more confident in establishing proper management for patients with DTC using radioiodine whole body scans. Research Support: N/A
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Lazaga, F., Sharma, S., Sharma, P., Williams, S. Tags: Educational Exhibits Posters Source Type: research

Crossed cerebellar diaschisis on F-18 FDG PET/CT and MRI/Functional MRI
Conclusion: CCD is likely to be permanent while a small percentage (15%) showed improvement or even complete resolution regardless of the causative insult (tumor or infarct). While MRI is the study of choice in evaluating the brain, it was not able to detect any evidence of abnormal morphology, signal or blood flow in the cerebellum of patients who have a supratentorial insult. Given the small number of cases with improvement of CCD, the clinical significance has yet to be determined. Research Support: None
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Bakdalieh, A., Osman, M., Muzaffar, R., Ghazala, H., Zhou, Y. Tags: Neurology Posters Source Type: research

Regional, Artery-Specific Thresholds of Quantitative Myocardial Perfusion by PET Associated with Reduced Myocardial Infarction and Death After Revascularization in Stable Coronary Artery Disease
Conclusion: CFC by PET provides objective, regional, artery-specific, size–severity physiologic quantification of CAD severity associated with high risk of DMS that is significantly reduced after revascularization within 90 d after PET, an association not seen for moderate to mild perfusion abnormalities or medical treatment alone.
Source: Journal of Nuclear Medicine - February 28, 2019 Category: Nuclear Medicine Authors: Gould, K. L., Johnson, N. P., Roby, A. E., Nguyen, T., Kirkeeide, R., Haynie, M., Lai, D., Zhu, H., Patel, M. B., Smalling, R., Arain, S., Balan, P., Nguyen, T., Estrera, A., Sdringola, S., Madjid, M., Nascimbene, A., Loyalka, P., Kar, B., Gregoric, I., S Tags: Clinical Source Type: research