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Low vitamin D status in relation to cardiovascular disease and mortality in Swedish women - effect of extended follow-up
The impact of vitamin D concentrations on subsequent cardiovascular disease (CVD) and overall mortality has been generally examined for periods under two decades. The magnitude of the association may depend on follow-up length. We aimed to investigate the relationship between baseline vitamin D and risk of total CVD, stroke and all-cause mortality over three decades of follow-up. Secondly, we aimed to assess how follow-up affects the associations.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 25, 2017 Category: Nutrition Authors: Monica Leu Agelii, Susanna Lehtinen-Jacks, Henrik Zetterberg, Valter Sundh, Cecilia Bj örkelund, Lauren Lissner Source Type: research

Low vitamin D status in relation to cardiovascular disease and mortality in Swedish women – Effect of extended follow-up
The impact of vitamin D concentrations on subsequent cardiovascular disease (CVD) and overall mortality has been generally examined for periods under two decades. The magnitude of the association may depend on follow-up length. We aimed to investigate the relationship between baseline vitamin D and risk of total CVD, stroke and all-cause mortality over three decades of follow-up. Secondly, we aimed to assess how follow-up affects the associations.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 25, 2017 Category: Nutrition Authors: M. Leu Agelii, S. Lehtinen-Jacks, H. Zetterberg, V. Sundh, C. Bj örkelund, L. Lissner Source Type: research

Dietary Vitamin C in Human Health.
Abstract Vitamin C is essential to prevent scurvy in humans and is implicated in the primary prevention of common and complex diseases such as coronary heart disease, stroke, and cancer. This chapter reviews the latest knowledge about dietary vitamin C in human health with an emphasis on studies of the molecular mechanisms of vitamin C maintenance as well as gene-nutrient interactions modifying these relationships. Epidemiological evidence indicates 5% prevalence for vitamin C deficiency and 13% prevalence for suboptimal status even in industrialized countries. The daily intake (dose) and the corresponding systemi...
Source: Advances in Food and Nutrition Research - February 27, 2018 Category: Nutrition Authors: Granger M, Eck P Tags: Adv Food Nutr Res Source Type: research

Vitamin B12.
Abstract The biosynthesis of B12, involving up to 30 different enzyme-mediated steps, only occurs in bacteria. Thus, most eukaryotes require an external source of B12, and yet the vitamin appears to have only two functions in eukaryotes: as a cofactor for the enzymes methionine synthase and methylmalonylCoA mutase. These two functions are crucial for normal health in humans, and in particular, the formation of methionine is essential for providing methyl groups for over 100 methylation processes. Interference with the methionine synthase reaction not only depletes the body of methyl groups but also leads to the ac...
Source: Advances in Food and Nutrition Research - February 27, 2018 Category: Nutrition Authors: Smith AD, Warren MJ, Refsum H Tags: Adv Food Nutr Res Source Type: research

Relevance of plasma levels of free homocysteine and methionine as risk predictors for ischemic stroke in the young
The debated vascular risk potential of total homocysteine (tHcy), due to failed clinical trials designed on B vitamin supplementation, raises many possible explanations like the higher risk potential of the deleterious, free form of homocysteine (fHcy) or, the unchecked confounding effects of B-vitamins in tHcy-based association studies. Additionally, the cardiovascular risk probability of altered status of the homocysteine precursor, methionine (tMet) could shed light on the causality of association between tHcy and cardiovascular diseases.
Source: Clinical Nutrition - July 13, 2017 Category: Nutrition Authors: Kondapura Jayadevappa Rudreshkumar, Vijaya Majumdar, Dindagur Nagaraja, Rita Christopher Tags: Original article Source Type: research

A Nested Case–Control Study on Plasma Vitamin E and Risk of Cancer: Evidence of Effect Modification by Selenium
ConclusionsThis study suggests that higher levels of plasma vitamin E are associated with reduced risk of gastrointestinal cancer. High vitamin E decreased the risk of total cancer among patients with high selenium levels, but increased the risk of total cancer among those with low selenium levels.
Source: Journal of the Academy of Nutrition and Dietetics - February 1, 2019 Category: Nutrition Source Type: research

Dietary total antioxidant capacity and severity of stenosis in patients with coronary artery disease.
Conclusions: There was a significant association between dietary TAC and severity of stenosis in patients with coronary artery disease. PMID: 31984875 [PubMed - as supplied by publisher]
Source: International Journal for Vitamin and Nutrition Research - January 29, 2020 Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research

Low Vitamin D Levels Predict Left Atrial Thrombus in Nonvalvular Atrial Fibrillation
We determined the association between left atrial (LA) thrombus occurrence and a non-classic risk marker, plasma levels of vitamin D, in atrial fibrillation (AF) patients on continuous non-vitamin K antagonist oral anticoagulant (NOAC) therapy for ≥4 weeks. Low levels of plasma 25-hydroxy vitamin D (25-OHD) are predictive of fatal stroke. Vitamin D has anticoagulant effects on the coagulation cascade, which are indirectly targeted by NOAC therapy. The impact of plasma levels of vitamin D on the rate of LA thrombus detected by transesophagea l echocardiography (TEE) in AF patients is unknown.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 8, 2020 Category: Nutrition Authors: Ozan M. Çakır Source Type: research

Vitamin C and scar strength: analysis of a historical trial and implications for collagen-related pathologies
Am J Clin Nutr. 2021 Aug 16:nqab262. doi: 10.1093/ajcn/nqab262. Online ahead of print.ABSTRACTA double-blind controlled trial initiated in 1944 has led to the common narrative that a 10-mg daily vitamin C intake is adequate to prevent and treat impaired wound healing, and by inference, other collagen-related diseases such as heart disease or stroke. The WHO relies on this narrative to set the recommended nutrient intake for vitamin C. This narrative, however, is based on what is known as the eyeball method of data assessment. The 1944 trial published individual participant data on scar strength providing an opportunity to ...
Source: The American Journal of Clinical Nutrition - August 16, 2021 Category: Nutrition Authors: Philippe P Hujoel Margaux L A Hujoel Source Type: research

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