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An Index From Transcranial Doppler Signals for Evaluation of Stroke Rehabilitation Using External Counterpulsation
This study aimed to develop a sensitive index from transcranial Doppler (TCD) signals for quantitatively evaluating the effects of long-term external counterpulsation (ECP) treatment on stroke rehabilitation. We recruited 27 patients with unilateral ischemic stroke and a good acoustic window within 7 days of stroke onset. 15 of them received 35 daily 1-hour ECP treatment (ECP group) and the others underwent conventional therapy without ECP treatment (No-ECP group). We monitored blood flow in middle cerebral arteries on both sides by TCD, and analyzed them via discrete wavelet analysis method. The overall changes of Nationa...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - July 30, 2021 Category: Neuroscience Source Type: research

Neuropsychological and neuroimaging assessments of early cognitive impairment in patients after mild ischemic stroke and transient ischemic attack.
This study aimed to identify markers of early cognitive impairment after acute mild ischemic cerebrovascular disease. To further explore the relationship between neuroimaging markers of vascular and neurodegenerative injuries and post-stroke cognitive impairment, 86 patients with transient ischemic attack/acute mild ischemic stroke were recruited. Demographic information, clinical data, stroke scale scores (Modified Rankin Scale, National Institutes of Health Stroke Scale), and neuroimaging parameters (medial temporal lobe atrophy, global cortical atrophy, white matter hyperintensities, location and number of acute infarct...
Source: Journal of Integrative Neuroscience - June 29, 2020 Category: Neuroscience Authors: Yang Y, Ye L, Lin R, Lin H, Tang T, Chen Y, Zhang J, Wang L Tags: J Integr Neurosci Source Type: research

Neuron-Specific Markers and their Correlation with Neurological Scales in Patients with Acute Neuropathologies
AbstractIn predicting outcomes in patients with acute brain injury, current practice focuses special attention on neuron-specific proteins that reliably reflect the severity of the lesion. Further studies of molecular markers and their specificity and sensitivity could contribute to broadening the understanding of pathophysiological, diagnostic, and prognostic methods, which is vital to reducing the mortality and disability associated with these critical conditions. The purpose of this study was to assess the biomarkers of brain lesions and their correlative relations with the integral Glasgow Coma Scale (GCS) and National...
Source: Journal of Molecular Neuroscience - April 28, 2020 Category: Neuroscience Source Type: research

Automated Scoring of Hemiparesis in Acute Stroke From Measures of Upper Limb Co-Ordination Using Wearable Accelerometry
Stroke survivors usually experience paralysis in one half of the body, i.e., hemiparesis, and the upper limbs are severely affected. Continuous monitoring of hemiparesis progression hours after the stroke attack involves manual observation of upper limb movements by medical experts in the hospital. Hence it is resource and time intensive, in addition to being prone to human errors and inter-rater variability. Wearable devices have found significance in automated continuous monitoring of neurological disorders like stroke. In this paper, we use accelerometer signals acquired using wrist-worn devices to analyze upper limb mo...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - March 31, 2020 Category: Neuroscience Source Type: research

Long noncoding RNA-regulator of reprogramming alleviates hypoxia-induced cerebral injury in mice model and human via modulating apoptosis complexes.
Abstract Ischemic stroke causes cerebral hypoxia, while long non-coding RNA regulator of reprogramming is associated with hypoxia. To find a new intervention target to protect hypoxic cerebral tissue and a potential biomarker from reflecting the severity of hypoxia after ischemic stroke, our research explored the expression pattern and function of the regulator of reprogramming in cerebral hypoxia-induced injury. The expression pattern and the function of the regulator of reprogramming were explored in mice with middle cerebral artery occlusion, and human brain microvascular endothelial cells underwent oxygen-gluc...
Source: Journal of Integrative Neuroscience - December 29, 2019 Category: Neuroscience Authors: Zhou Q, An Y, Tang Y Tags: J Integr Neurosci Source Type: research

Prevalence of hypohydration and its association with stroke severity and independence outcomes in acute ischemic stroke patients
Publication date: Available online 11 December 2019Source: Journal of Clinical NeuroscienceAuthor(s): Alex Buoite Stella, Marina Gaio, Giovanni Furlanis, Mariana Ridolfi, Miloš Ajčević, Arianna Sartori, Paola Caruso, Shawnda A. Morrison, Marcello Naccarato, Paolo ManganottiAbstractHypohydration has been suggested increasing the risk of vascular diseases, and it is associated with poor prognosis and worse functional outcome in stroke. Most studies have used blood parameters to determine patients’ hydration status. The aim of this study was to measure urine osmolality (uOsm) and its influence on stroke severity and inde...
Source: Journal of Clinical Neuroscience - December 12, 2019 Category: Neuroscience Source Type: research

Clinical outcomes of moderate to severe acute ischemic stroke in a telemedicine network
The objective of this study was to analyze clinical and imaging based outcomes of moderate to severe stroke following treatment with thrombolysis, thrombectomy or a combination of both in a telemedicine network. Data of this retrospective study was abstracted from the institutional telestroke database. Patients with a National Institute of Health Stroke Scale score (NIH-SS ≥ 10) were included into the study. Primary outcome measure was the difference in NIH-SS at admission compared to discharge from the hospital. Secondary outcome measure was the discharge disposition defined as favorable (discharge to home or rehabi...
Source: Journal of Clinical Neuroscience - November 2, 2019 Category: Neuroscience Source Type: research

Brachial-ankle pulse wave velocity for predicting functional outcomes in patients with cryptogenic stroke
Publication date: Available online 18 July 2019Source: Journal of Clinical NeuroscienceAuthor(s): Minho Han, Young Dae Kim, Hyung Jong Park, In Gun Hwang, Junghye Choi, Jimin Ha, Ji Hoe Heo, Hyo Suk NamAbstractEven after extensive standard evaluation, the probable cause of stroke in some patients remains unclear; this condition is defined as cryptogenic stroke (CS). The prognosis of patients with CS is largely undetermined. We investigated whether higher brachial-ankle pulse wave velocities (baPWVs) can predict poor functional outcomes at 3 months after stroke onset in these patients. We investigated patients with CS wit...
Source: Journal of Clinical Neuroscience - July 20, 2019 Category: Neuroscience Source Type: research

A troponin study on patients with ischemic stroke, intracerebral hemorrhage and subarachnoid hemorrhage: Type II myocardial infarction is significantly associated with stroke severity, discharge disposition and mortality
Publication date: Available online 20 April 2019Source: Journal of Clinical NeuroscienceAuthor(s): Ayham M. Alkhachroum, Benjamin Miller, Tarek Chami, Curtis Tatsuoka, Cathy SilaAbstractTroponin elevations due to Type II myocardial infarction (T2MI) are associated with hemorrhagic and ischemic strokes but there is little data on stroke severity, troponin elevation and outcome. We studied 1655 patients from a tertiary medical center between 1/2013-4/2015 using multivariate regression analysis for demographics, vascular risk factors, admission stroke severity, laboratory tests, echocardiogram results and discharge dispositio...
Source: Journal of Clinical Neuroscience - April 21, 2019 Category: Neuroscience Source Type: research

Blood microRNA-93 as an indicator for diagnosis and prediction of functional recovery of acute stroke patients
Publication date: Available online 19 December 2018Source: Journal of Clinical NeuroscienceAuthor(s): Qingfeng Ma, Guangwen Li, Zhen Tao, Jue Wang, Rongliang Wang, Ping Liu, Yumin Luo, Haiping ZhaoAbstractThe present study evaluated the diagnostic and predictive potential of microRNA-93 in acute ischemic stroke (AIS) patients within 6 h of stroke onset and its regulation on microglial inflammation in vitro. Our results showed that the miR-93 levels in plasma and neutrophil detected by real-time PCR were evidently reduced in AIS patients, and Pearson's correlation analysis showed that miR-93 levels in plasma and neutrophi...
Source: Journal of Clinical Neuroscience - December 20, 2018 Category: Neuroscience Source Type: research

HDAC9 Polymorphisms Predict Susceptibility, Severity, and Short-Term Outcome of Large Artery Atherosclerotic Stroke in Chinese Population
This study aimed to investigate whether these two polymorphisms were associated with susceptibility, severity, and short-term outcome of LAA stroke in a southern Chinese Han population. rs2074633 and rs28688791 were genotyped using SNPscan technology in 1011 LAA stroke patients and 1121 healthy controls. Stroke severity on admission and short-term outcome were, respectively, assessed by the National Institute of Health Stroke Scale (NIHSS) score on admission and modified Rankin Scale score at 3  months after stroke onset. rs2074633 (P = 0.039) and rs28688791 (P = 0.025) were associated with risk of LAA stroke. In ...
Source: Journal of Molecular Neuroscience - December 18, 2018 Category: Neuroscience Source Type: research

Thrombectomy in stroke of unknown onset, wake up stroke and late presentations: Australian experience from 2 comprehensive stroke centres
This study shows good ‘real world’ outcomes, comparable to published RCTs, in patients with unknown-onset, or late presentation, stroke treated with EVT more than 6 h from stroke onset.
Source: Journal of Clinical Neuroscience - November 8, 2018 Category: Neuroscience Source Type: research

Association of lower leukocyte count before thrombolysis with early neurological improvement in acute ischemic stroke patients
Publication date: Available online 17 August 2018Source: Journal of Clinical NeuroscienceAuthor(s): Canhui Tian, Zhong Ji, Wei Xiang, Xiaomei Huang, Shengnan Wang, Yongmin Wu, Suyue Pan, Liang Zhou, Zhen DengAbstractEarly neurological improvement (ENI) after thrombolysis in acute ischemic stroke is associated with a favorable long-term outcome. With the goal to evaluate ENI, we aimed to investigate whether ENI bears a relationship with routine blood tests before thrombolysis. A total of 240 patients with confirmed early ischemic stroke and intravenous recombinant tissue plasminogen activator (rtPA) treatment were enrolled ...
Source: Journal of Clinical Neuroscience - August 17, 2018 Category: Neuroscience Source Type: research

Serum Coenzyme Q10 Is Associated with Clinical Neurological Outcomes in Acute Stroke Patients
This study aims at measuring serum concentration of CoQ10 along with major indicators of antioxidant and oxidant among patients within 24  h after onset of the stroke symptoms, and investigating their relation with the clinical status of patients. Serum levels of CoQ10, superoxide dismutase (SOD), and malondialdehyde (MDA) were measured in 76 patients and 34 healthy individuals. Severity of the neurological deficit, functional disabi lity, and cognitive status in ischemic subjects were respectively studied with the National Institutes of Health stroke scale (NIHSS), modified Rankin Scale (MRS), and Mini-Mental State Exami...
Source: Journal of Molecular Neuroscience - August 9, 2018 Category: Neuroscience Source Type: research

Serum 25-hydroxyvitamin D deficiency predicts poor outcome among acute ischemic stroke patients without hypertension
Publication date: Available online 3 May 2018Source: Neurochemistry InternationalAuthor(s): Bingjun Zhang, Yuge Wang, Yi Zhong, Siyuan Liao, Zhengqi LuAbstract25-Hydroxyvitamin D (25(OH)D) deficiency is a frequent condition in patients who suffer acute ischemic stroke (AIS), and several studies suggested that it may be associated with a poorer prognosis. Whether this association is affected by hypertension is unclear. Our aim was to investigate the association between 25(OH)D levels and both clinical severity and outcome after 3 months in AIS patients stratified by the history of hypertension. Consecutive first-ever AIS pa...
Source: Neurochemistry International - July 10, 2018 Category: Neuroscience Source Type: research

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