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Total 698 results found since Jan 2013.
Burdening Perspectives and Treatment Modalities of Monkeypox: A Central Dogma
Infect Disord Drug Targets. 2023 Aug 25. doi: 10.2174/1871526523666230825164222. Online ahead of print.ABSTRACTThe monkeypox virus (MPXV), belonging to the genus Orthopoxvirus, is responsible for causing the zoonotic illness known as Monkeypox. The virus was initially identified during an outbreak at a Danish Zoo in 1958 and has since been found to infect various mammal species worldwide. While African squirrels and other rodents are believed to be the primary hosts, determining the natural host has proven challenging. While MPXV can be studied using different animal models in laboratory settings, understanding its natural...
Source: Infectious Disorders Drug Targets - September 12, 2023 Category: Infectious Diseases Authors: Shivang Dhoundiyal Md Aftab Alam Awaneet Kaur Sandesh Varshney Source Type: research
Meeting report: Towards better risk stratification, prevention and therapy of invasive GBS disease, ESPID research meeting May 2022
Vaccine. 2023 Sep 10:S0264-410X(23)01068-X. doi: 10.1016/j.vaccine.2023.09.014. Online ahead of print.ABSTRACTThe European Society of Pediatric Infectious Diseases (ESPID) hosted the third Group B Streptococcus (GBS) Research Session in Athens on 11th May 2022, providing researchers and clinicians from around the world an opportunity to share and discuss recent advances in GBS pathophysiology, molecular and genetic epidemiology and how these new insights can help in improving prevention and control of early- and late-onset GBS disease. The meeting provided a state-of-the-art overview of the existing GBS prevention strategi...
Source: Vaccine - September 12, 2023 Category: Allergy & Immunology Authors: Linde Snoek Konstantinos Karampatsas Merijn W Bijlsma Philipp Henneke Elita Jauneikaite Uzma B Khan Ruth N Zadoks Kirsty Le Doare Source Type: research
Detection of immune effects of the Mannheimia haemolytica gamma irradiated vaccine in sheep
In conclusion, the vaccinated sheep are protected by the elevated IgG titer and increased levels of IL-4 (Th-2 response) compared to the non-vaccinated sheep. Radiation technology can provide the opportunity for mass production of immunologically safe vaccines against animal and zoonotic diseases. Ethics Approval by the National Research Center Ethics Committee (Trial Registration Number (TRN) no 13,602,023, 13/5/2023) was obtained.PMID:37642819 | DOI:10.1007/s11259-023-10207-w
Source: Cell Research - August 29, 2023 Category: Cytology Authors: Sahar Ahmed Mohamed Abd El-Fatah Mahmoud Waleed Abdelgaber Nemr Eman Hussein Abdel-Rahman Asmaa El-Shershaby Ehab Ali Fouad Fatima Liaqat Viskam Wijewardana Source Type: research
"EvoVax" - A rationally designed inactivated Salmonella Typhimurium vaccine induces strong and long-lasting immune responses in pigs
In this study we tested safety and immunogenicity of an oral inactivated S.Tm vaccine, which has been recently shown to generate an "evolutionary trap" and to massively reduce S.Tm colonization and transmission in mice. We show that this vaccine is highly immunogenic and safe in post-weaning pigs and that administration of a single oral dose results in a strong and long-lasting serum IgG response. This has several advantages over existing - mainly live - vaccines against S.Tm, both in improved seroconversion and reduced risk of vaccine-strain persistence and reversion to virulence.PMID:37517910 | DOI:10.1016/j.vaccine.2023.07.059
Source: Vaccine - July 30, 2023 Category: Allergy & Immunology Authors: Verena Lentsch Selma Aslani Thomas Echtermann Swapan Preet Elisa Cappio Barazzone Daniel Hoces Claudia Moresi Dolf K ümmerlen Emma Slack Source Type: research
Bioinformatics-based design of a fusion vaccine with CTLA-4 variable region to combat Brucella
This study showed that the designed vaccine containing CTLA-4 had high potency against Brucella, which could provide a reference for the future development of efficient brucellosis vaccines.PMID:37493775 | PMC:PMC10361638 | DOI:10.1590/1414-431X2023e12938
Source: Braz J Med Biol Res - July 26, 2023 Category: Research Authors: W H Guo Y J Zhu G Haimiti X R Xie C Niu M Li J Shi Z W Yin M K Yu J B Ding F B Zhang Source Type: research
Epidemiology-driven approaches to surveillance in HPAI-vaccinated poultry flocks aiming to demonstrate freedom from circulating HPAIV
Biologicals. 2023 Jul 24;83:101694. doi: 10.1016/j.biologicals.2023.101694. Online ahead of print.ABSTRACTIncursion pressure of high pathogenicity avian influenza viruses (HPAIV) by secondary spread among poultry holdings and/or from infected migratory wild bird populations increases worldwide. Vaccination as an additional layer of protection of poultry holdings using appropriately matched vaccines aims at reducing clinical sequelae of HPAIV infection, disrupting HPAIV transmission, curtailing economic losses and animal welfare problems and cutting exposure risks of zoonotic HPAIV at the avian-human interface. Products der...
Source: Biologicals : Journal of the International Association of Biological Standardization - July 26, 2023 Category: Biotechnology Authors: Timm Harder Sjaak de Wit Jose L Gonzales Jeremy H P Ho Paolo Mulatti Teguh Y Prajitno Arjan Stegeman Source Type: research
