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Apolipoprotein A-I vascular gene therapy reduces vein-graft atherosclerosis
Mol Ther Methods Clin Dev. 2023 Aug 22;30:558-572. doi: 10.1016/j.omtm.2023.08.018. eCollection 2023 Sep 14.ABSTRACTCoronary artery venous bypass grafts typically fail because of atherosclerosis driven by lipid and macrophage accumulation. Therapy for vein-graft atherosclerosis is limited to statin drugs, which are only modestly effective. We hypothesized that transduction of vein-graft endothelium of fat-fed rabbits with a helper-dependent adenovirus expressing apolipoprotein AI (HDAdApoAI) would reduce lipid and macrophage accumulation. Fat-fed rabbits received bilateral external jugular vein-to-carotid artery interposit...
Source: Atherosclerosis - September 11, 2023 Category: Cardiology Authors: Lianxiang Bi Bradley K Wacker Kaushik Komandur Nicole Sanford David A Dichek Source Type: research

Induction of KLF2 by exercise activates eNOS to improve vasodilatation in diabetic mice
Diabetes. 2023 Jun 22:db230070. doi: 10.2337/db23-0070. Online ahead of print.ABSTRACTDiabetic endothelial dysfunction associated with diminished endothelial nitric oxide synthase (eNOS) activity accelerates the development of atherosclerosis and cardiomyopathy. However, the approaches to restore eNOS activity and endothelial function in diabetes remain limited. The present study shows that enhanced expression of KLF2, a shear stress-inducible transcription factor, effectively improves endothelial function through increasing NO bioavailability. KLF2 expression is suppressed in diabetic mouse aortic endothelium. Running exe...
Source: Atherosclerosis - June 22, 2023 Category: Cardiology Authors: Jiang-Yun Luo Chak Kwong Cheng Lingshan Gou Lei He Lei Zhao Yang Zhang Li Wang Chi Wai Lau Aimin Xu Alex F Chen Yu Huang Source Type: research

Lipid Lowering Therapy: An Era Beyond Statins
Curr Probl Cardiol. 2022 Jul 30:101342. doi: 10.1016/j.cpcardiol.2022.101342. Online ahead of print.ABSTRACTDyslipidemia, specifically elevated LDL cholesterol levels, causes atherosclerotic cardiovascular disease (ASCVD) and increases the risk of myocardial infarction and stroke. Statins, a class of drugs that exert their effects by inhibiting HMG-CoA reductase, a key enzyme in the synthesis of cholesterol, have been the mainstay of therapy for the primary prevention of cardiovascular disease and lipids reduction. Statins are associated with side effects, most commonly myopathy and myalgias, despite their proven efficacy....
Source: Atherosclerosis - August 2, 2022 Category: Cardiology Authors: Toufik Abdul-Rahman Syed Muhammad Awais Bukhari Emiliano Cantu Herrera Wireko Andrew Awuah Jannel Lawrence Heloisa de Andrade Neal Patel Rohan Shah Raheel Shaikh Camilo Andr és Avendaño Capriles Sebahat Ulusan Shahzaib Ahmad Anna Corriero Adriana C Mare Source Type: research

Endothelial UCP2 Is a Mechanosensitive Suppressor of Atherosclerosis
CONCLUSIONS: Altogether, our studies uncover that UCP2 is novel mechanosensitive gene under the control of fluid shear stress and KLF2 in ECs. UCP2 expression is critical for endothelial proinflammatory response and atherogenesis. Therapeutic strategies enhancing UCP2 level may have therapeutic potential against atherosclerosis.PMID:35899624 | DOI:10.1161/CIRCRESAHA.122.321187
Source: Circulation Research - July 28, 2022 Category: Cardiology Authors: Jiang-Yun Luo Chak Kwong Cheng Lei He Yujie Pu Yang Zhang Xiao Lin Aimin Xu Chi Wai Lau Xiao Yu Tian Ronald Ching Wan Ma Hanjoong Jo Yu Huang Source Type: research

Atorvastatin reduces IOP in ocular hypertension < em > in  vivo < /em > and suppresses ECM in trabecular meshwork perhaps via FGD4
Int J Mol Med. 2022 Jun;49(6):76. doi: 10.3892/ijmm.2022.5132. Epub 2022 Apr 13.ABSTRACTTo explore the role of atorvastatin in regulating intraocular pressure (IOP) in glaucoma in vivo, and to investigate its related molecular pathway in vitro, an ocular hypertension model was generated by intravitreal injection of an adenoviral vector encoding transforming growth factor (TGF)‑β2 in the right eye of BALB/cJ mice, while the left was treated with an empty control adenovirus. To determine its anti‑intraocular hypertension role, these induced hyper‑IOP mice were gavaged with atorvastatin (20 mg/kg/day). Furthermore, ext...
Source: Molecular Medicine - April 13, 2022 Category: Molecular Biology Authors: Xiang-Yuan Song Ya-Ying Chen Wen-Ting Liu Lin Cong Jin-Ling Zhang Yang Zhang Yu-Yan Zhang Source Type: research

Fight Aging! Newsletter, December 23rd 2019
In this study, by adenovirus-mediated delivery and inducible transgenic mouse models, we demonstrate the proliferation of both HCs and SCs by combined Notch1 and Myc activation in in vitro and in vivo inner ear adult mouse models. These proliferating mature SCs and HCs maintain their respective identities. Moreover, when presented with HC induction signals, reprogrammed adult SCs transdifferentiate into HC-like cells both in vitro and in vivo. Finally, our data suggest that regenerated HC-like cells likely possess functional transduction channels and are able to form connections with adult auditory neurons. Epige...
Source: Fight Aging! - December 22, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs