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Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Hypothalamic TrkB.FL overexpression improves metabolic outcomes in the BTBR mouse model of autism
PLoS One. 2023 Mar 9;18(3):e0282566. doi: 10.1371/journal.pone.0282566. eCollection 2023.ABSTRACTBTBR T+ Itpr3tf/J (BTBR) mice are used as a model of autism spectrum disorder (ASD), displaying similar behavioral and physiological deficits observed in patients with ASD. Our recent study found that implementation of an enriched environment (EE) in BTBR mice improved metabolic and behavioral outcomes. Brain-derived neurotrophic factor (Bdnf) and its receptor tropomyosin kinase receptor B (Ntrk2) were upregulated in the hypothalamus, hippocampus, and amygdala by implementing EE in BTBR mice, suggesting that BDNF-TrkB signaling...
Source: Cancer Control - March 9, 2023 Category: Cancer & Oncology Authors: Jacqueline M Anderson Amber A Boardman Rhiannon Bates Xunchang Zou Wei Huang Lei Cao Source Type: research
KLHL3 deficiency in mice ameliorates obesity, insulin resistance, and nonalcoholic fatty liver disease by regulating energy expenditure
We examined differences in obesity-related parameters between control and Klhl3-/- mice. A significant decrease in body weight concomitant with fat mass loss and improved IR and NAFLD were observed in Klhl3-/- mice fed a high-fat (HF) diet and aged. KLHL3 deficiency inhibited obesity, IR, and NAFLD by increasing energy expenditure with augmentation of O2 consumption and CO2 production. Delivering dominant-negative (DN) Klhl3 using adeno-associated virus into mice, thereby dominantly expressing DN-KLHL3 in the liver, ameliorated diet-induced obesity, IR, and NAFLD. Finally, adenoviral overexpression of DN-KLHL3, but not wil...
Source: Molecular Medicine - August 26, 2022 Category: Molecular Biology Authors: Ju-Hong Jang Jeong Woong Lee Min Ji Cho Byungtae Hwang Min-Gi Kwon Dong-Hwan Kim Nam-Kyung Lee Jangwook Lee Young-Jun Park Yong Ryoul Yang Jinchul Kim Yong-Hoon Kim Tae Hyeon An Kyoung-Jin Oh Kwang-Hee Bae Jong-Gil Park Jeong-Ki Min Source Type: research
Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice
We report here that BDNF (brain derived neurotrophic factor) provokes mitochondrial fission and clearance in skeletal muscle via the PRKAA/AMPK-PINK1-PRKN/Parkin and PRKAA-DNM1L/DRP1-MFF pathways. Depleting Bdnf expression in myotubes reduced fatty acid-induced mitofission and mitophagy, which was associated with mitochondrial elongation and impaired lipid handling. Muscle-specific bdnf knockout (MBKO) mice displayed defective mitofission and mitophagy, and accumulation of dysfunctional mitochondria in the muscle when they were fed with a high-fat diet (HFD). These animals also have exacerbated body weight gain, increased ...
Source: Autophagy - October 25, 2021 Category: Cytology Authors: Palak Ahuja Chun Fai Ng Brian Pak Shing Pang Wing Suen Chan Margaret Chui Ling Tse Xinyi Bi Hiu-Lam Rachel Kwan Daniel Brobst Oana Herlea-Pana Xiuying Yang Guanhua Du Suchaorn Saengnipanthkul Hye Lim Noh Baowei Jiao Jason K Kim Chi Wai Lee Keqiang Ye Chi Source Type: research
Enoyl coenzyme A hydratase 1 alleviates nonalcoholic steatohepatitis in mice by suppressing hepatic ferroptosis
Am J Physiol Endocrinol Metab. 2021 Apr 5. doi: 10.1152/ajpendo.00614.2020. Online ahead of print.ABSTRACTNon-alcoholic steatohepatitis (NASH) is a common metabolic disorder that is a major contributor to health care expenditures worldwide. Enoyl coenzyme A hydratase 1 (ECH1) is initially recognized as a key component in mitochondrial fatty acid β-oxidation, and subsequent studies have demonstrated that it regulates multiple pathophysiological processes. However, the relationship between ECH1 and NASH has remained largely unknown. Herein, we investigated the role of ECH1 in NASH progression. Adeno-associated virus-mediate...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 5, 2021 Category: Physiology Authors: Bing Liu Wei Yi Xiaoxiang Mao Ling Yang Caijun Rao Source Type: research
Hypothalamic gene transfer of BDNF promotes healthy aging
Vitam Horm. 2021;115:39-66. doi: 10.1016/bs.vh.2020.12.003. Epub 2021 Jan 30.ABSTRACTThe aging process and age-related diseases all involve metabolic decline and impaired ability to cope with adversity. Environmental enrichment (EE)-a housing environment which recapitulates aspects of active lifestyle-exerts a wide range of health benefits in laboratory rodents. Brain-derived neurotrophic factor (BDNF) in the hypothalamus orchestrates autonomic and neuroendocrine processes, serving as one key brain mediator of EE-induced resistance to obesity, cancer, and autoimmunity. Recombinant adeno-associated virus (AAV)-mediated hypo...
Source: Vitamins and Hormones - March 12, 2021 Category: Endocrinology Authors: Lei Cao Seemaab Ali Nicholas J Queen Source Type: research
