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Infectious Disease: Influenza
Vaccination: Veterinary Vaccinations

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Total 550 results found since Jan 2013.

Evaluation the effect of dietary vitamin E, sesamin and thymoquinone bioactive compounds on immunological response, intestinal traits and MUC-2 gene expression in broiler Japanese quails ( < em > Coturnix japonica < /em > )
Anim Biotechnol. 2023 Sep 20:1-11. doi: 10.1080/10495398.2023.2259437. Online ahead of print.ABSTRACTThe current study was performed to determine the effect of dietary vitamin E, sesamin and thymoquinone bioactive lignans derived from sesame and black seed on immunological response, intestinal traits and Mucin2 gene expression in broiler quails. Three hundred and fifty (one days-old) quails were allotted to seven dietary treatments with five replicates as an experimental randomized design study. Treatments were basal diet as a control, control +100 and +200 mg of vitamin E, sesamin and thymoquinone per each kg of diet resp...
Source: Animal Biotechnology - September 20, 2023 Category: Biotechnology Authors: Yaser Rahimian Farshid Kheiri Mostafa Faghani Source Type: research

The Use of < em > In Silico < /em > Methods to Identify and Assess Antigenic Regions Suitable for the Development of Peptide-based Pan-viral Vaccines
We report a pan-antigenic peptide region with strong affinity for MHC-I and MHC-II, and good immunogenic potential. According to the output from the relevant in silico tools, the peptide was predicted to be non-toxic, non-allergic and to possess the desired physicochemical properties for potentially successful vaccine production. With further investigation and optimisation, this peptide could be considered for use in the development of a broad-spectrum anti-viral vaccine that may protect against emerging new viruses. Our approach of using in silico methods to identify candidate antigenic peptides with the desired physicoch...
Source: Alternatives to Laboratory Animals : ATLA - August 7, 2023 Category: Research Authors: Shayana Saravanakumar Jhinuk Chatterjee Source Type: research

Epidemiology-driven approaches to surveillance in HPAI-vaccinated poultry flocks aiming to demonstrate freedom from circulating HPAIV
Biologicals. 2023 Jul 24;83:101694. doi: 10.1016/j.biologicals.2023.101694. Online ahead of print.ABSTRACTIncursion pressure of high pathogenicity avian influenza viruses (HPAIV) by secondary spread among poultry holdings and/or from infected migratory wild bird populations increases worldwide. Vaccination as an additional layer of protection of poultry holdings using appropriately matched vaccines aims at reducing clinical sequelae of HPAIV infection, disrupting HPAIV transmission, curtailing economic losses and animal welfare problems and cutting exposure risks of zoonotic HPAIV at the avian-human interface. Products der...
Source: Biologicals : Journal of the International Association of Biological Standardization - July 26, 2023 Category: Biotechnology Authors: Timm Harder Sjaak de Wit Jose L Gonzales Jeremy H P Ho Paolo Mulatti Teguh Y Prajitno Arjan Stegeman Source Type: research

Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues. Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/ With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Enhanced HPV16 E6/E7 < sup > + < /sup > tumor eradication via induction of tumor-specific T cells by therapeutic vaccination with virosomes presenting synthetic long peptides
Cancer Immunol Immunother. 2023 May 24. doi: 10.1007/s00262-023-03462-y. Online ahead of print.ABSTRACTTherapeutic cancer vaccines trigger CD4 + and CD8 + T cell responses capable of established tumor eradication. Current platforms include DNA, mRNA and synthetic long peptide (SLP) vaccines, all aiming at robust T cell responses. SLPs linked to the Amplivant® adjuvant (Amplivant-SLP) have shown effective delivery to dendritic cells, resulting in improved immunogenicity in mice. We have now tested virosomes as a delivery vehicle for SLPs. Virosomes are nanoparticles made from influenza virus membranes and have been used as...
Source: Cancer Control - May 24, 2023 Category: Cancer & Oncology Authors: Toon Stegmann Anna-Sophia Wiekmeijer Kitty Kwappenberg Suzanne van Duikeren Farien Bhoelan Denzel Bemelman Thomas J M Beenakker Willem-Jan Krebber Ramon Arens Cornelis J M Melief Source Type: research

35 What is known about the pharmacology of intramuscular therapeutics in duchenne muscular dystrophy? A systematic review
Conclusions There is very limited evidence into the pharmaco-kinetics and -dynamics of IM therapies for children affected by muscular dystrophy. Given the recognised changes in the muscle structure and function, studies to explore if this causes clinically significant changes in boys with DMD are required.
Source: Archives of Disease in Childhood - May 18, 2023 Category: Pediatrics Authors: Roberts, E., Yi Gan, J., Hawcutt, D., Spinty, S. Tags: General abstracts Source Type: research

Induction of Homosubtypic and Heterosubtypic Immunity to Influenza Viruses Using a Conserved Internal and External Proteins
Curr Microbiol. 2023 May 16;80(6):212. doi: 10.1007/s00284-023-03331-y.ABSTRACTThe immunogenicity and protective properties of the designed recombinant fusion peptide of 3M2e and truncated nucleoprotein (trNP), originating from Influenza A virus, were investigated in the BALB/c mice model in comparison with the Mix protein (3M2e + trNP). The results were evaluated by antibody response, cytokine production, lymphocyte proliferation assay, and mortality rate after challenge with homologous (H1N1) and heterologous (H3N2) influenza viruses in BALB/c mice. The animals that received the chimer protein with or without adjuvant ha...
Source: Current Microbiology - May 16, 2023 Category: Microbiology Authors: Mahnoosh Maleki Seyed Masoud Hosseini Behrokh Farahmand Maryam Saleh Hadiseh Shokouhi Ali Torabi Fatemeh Fotouhi Source Type: research

Evaluation of early single dose vaccination on swine influenza A virus transmission in piglets: From experimental data to mechanistic modelling
Vaccine. 2023 Apr 13:S0264-410X(23)00401-2. doi: 10.1016/j.vaccine.2023.04.018. Online ahead of print.ABSTRACTSwine influenza A virus (swIAV) is a major pathogen affecting pigs with a huge economic impact and potentially zoonotic. Epidemiological studies in endemically infected farms permitted to identify critical factors favoring on-farm persistence, among which maternally-derived antibodies (MDAs). Vaccination is commonly practiced in breeding herds and might be used for immunization of growing pigs at weaning. Althoughinterference between MDAs and vaccination was reported in young piglets, its impact on swIAV transmissi...
Source: Vaccine - April 15, 2023 Category: Allergy & Immunology Authors: M Andraud S Herv é S Gorin N Barbier S Qu éguiner F Paboeuf G Simon N Rose Source Type: research