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Infectious Disease: Tuberculosis

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Total 35529 results found since Jan 2013.

Severe Tuberculosis Requiring Intensive Care: A Descriptive Analysis.
Conclusion. This cohort of TB patients requiring intensive care presented a high mortality rate. Most risk factors for mortality were related to organ failure, but others could be attributed to delay in the diagnostic and therapeutic approach, important targets for intervention. PMID: 28250986 [PubMed - in process]
Source: Critical Care Research and Practice - March 3, 2017 Category: Intensive Care Tags: Crit Care Res Pract Source Type: research

Emergency Medicine Providers' Knowledge and Management of Pediatric Tropical Diseases: A Needs Assessment
Conclusions Pediatric EM and EM providers' knowledge and evaluation for pediatric tropical diseases are variable. Providers recognized their knowledge gaps and expressed interest in gaining access to resources and guidelines to standardize and improve evaluation and treatment of these diseases.
Source: Pediatric Emergency Care - October 31, 2020 Category: Emergency Medicine Tags: Original Articles Source Type: research

Response to Hypoxia and the Ensuing Dysregulation of Inflammation Impacts < em > Mycobacterium tuberculosis < /em > Pathogenicity
CONCLUSIONS: Our results show that the response to hypoxia is a critical mediator of virulence determination in Mtb with potential impacts on bacillary persistence, reactivation and efficiency of therapeutics. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:35412961 | DOI:10.1164/rccm.202112-2747OC
Source: American Journal of Respiratory and Critical Care Medicine - April 12, 2022 Category: Respiratory Medicine Authors: Allison N Buc şan Ashley Veatch Dhiraj K Singh Sadia Akter Nadia A Golden Melanie Kirkpatrick Breanna Threeton Chivonne Moodley Mushtaq Ahmed Lara A Doyle Kasi Russell-Lodrigue Elizabeth B Norton Peter J Didier Chad J Roy Robert B Abramovitch Smriti Mehr Source Type: research

The Mischief and the Good In Precision Medicine
By MERCEDITAS VILLANUEVA, MD When The White House announced their Precision Medicine Initiative last year, they referred to precision medicine as “a new era of medicine,” signaling a shift in focus from a “one-size-fits-all-approach” to individualized care based on the specific characteristics that distinguish one patient from another. While there continues to be immense excitement about its game-changing impact in terms of early diagnoses and targeting specific treatment options, the advancements in technology, which underlie this approach, may not always yield the best medical results. In some cases, low cost ap...
Source: The Health Care Blog - June 22, 2016 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Gene Expert Precision Medicine Initiative tuberculosis Source Type: blogs

An All-Oral 6-Month Regimen for Multidrug-Resistant TB (the NExT Study): A Multicenter, Randomized Controlled Trial
CONCLUSIONS: An all-oral 6-month levofloxacin, bedaquiline and linezolid-containing MDR/RR-TB regimen was associated with significantly improved 24-month treatment outcomes compared with traditional injectable-containing regimens. However, drug toxicity occurred frequently in both arms. These findings inform strategies to develop future regimens for MDR/RR-TB. Clinical trial registration available at www.clinicaltrials.gov, ID: NCT02454205.PMID:35175905 | DOI:10.1164/rccm.202107-1779OC
Source: American Journal of Respiratory and Critical Care Medicine - February 17, 2022 Category: Respiratory Medicine Authors: Aliasgar Esmail Suzette Oelofse Carl Lombard Rubeshan Perumal Linda Mbuthini Akhter Goolam Mahomed Ebrahim Variava John Black Patrick Oluboyo Nelile Gwentshu Eric Ngam Tertius Ackerman Linde Marais Lynelle Mottay Stuart Meier Anil Pooran Michele Tomasicch Source Type: research

Management of HIV-infected patients in the intensive care unit
AbstractThe widespread use of combination antiretroviral therapies (cART) has converted the prognosis of HIV infection from a rapidly progressive and ultimately fatal disease to a chronic condition with limited impact on life expectancy. Yet, HIV-infected patients remain at high risk for critical illness due to the occurrence of severe opportunistic infections in those with advanced immunosuppression (i.e., inaugural admissions or limited access to cART), a pronounced susceptibility to bacterial sepsis and tuberculosis at every stage of HIV infection, and a rising prevalence of underlying comorbidities such as chronic obst...
Source: Intensive Care Medicine - February 2, 2020 Category: Intensive Care Source Type: research

COVID-19: guidance on palliative care from a European Respiratory Society international task force
Conclusion This multi-national task force provides consensus recommendations for palliative care for patients with COVID-19 concerning: advance care planning; (pharmacological) palliative treatment of breathlessness; clinician–patient communication; remote clinician–family communication; palliative care involvement in patients with serious COVID-19; spiritual care; psychosocial care; and bereavement care. Future studies are needed to generate empirical evidence for these recommendations.
Source: European Respiratory Journal - September 2, 2020 Category: Respiratory Medicine Authors: Janssen, D. J. A., Ekström, M., Currow, D. C., Johnson, M. J., Maddocks, M., Simonds, A. K., Tonia, T., Marsaa, K. Tags: Respiratory infections and tuberculosis Task Force Report Source Type: research

Precision-enhancing Risk Stratification Tools for Selecting Optimal Treatment Durations in Tuberculosis Clinical Trials
CONCLUSIONS: Our model discrimination was modest but consistent with current models of unfavorable outcomes. Our results showed that stratified medicine approaches is feasible and may achieve high cure rates in all tuberculosis patients. An interactive risk stratification tool is provided to facilitate decision making in the regimen development pathway.PMID:34346856 | DOI:10.1164/rccm.202101-0117OC
Source: American Journal of Respiratory and Critical Care Medicine - August 4, 2021 Category: Respiratory Medicine Authors: Marjorie Z Imperial Patrick P J Phillips Payam Nahid Radojka M Savic Source Type: research

A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis Treatment
CONCLUSIONS: An automated pharmacogenomic assay on a platform widely used globally for tuberculosis diagnosis could enable personalized dosing of isoniazid.PMID:34375564 | DOI:10.1164/rccm.202103-0564OC
Source: American Journal of Respiratory and Critical Care Medicine - August 10, 2021 Category: Respiratory Medicine Authors: Renu Verma Sunita Patil Nan Zhang Flora M F Moreira Marize T Vitorio Andrea da S Santos Ellen Wallace Devasena Gnanashanmugam David Persing Rada Savic Julio Croda Jason R Andrews Source Type: research

Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis
Conclusions Positive RISK11 signature status is often transient, possibly due to intercurrent viral infection, highlighting potentially important challenges for implementation of these biomarkers as new tools for TB control. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:34520313 | DOI:10.1164/rccm.202103-0548OC
Source: American Journal of Respiratory and Critical Care Medicine - September 14, 2021 Category: Respiratory Medicine Authors: Humphrey Mulenga Munyaradzi Musvosvi Simon C Mendelsohn Adam Penn-Nicholson Stanley Kimbung Mbandi Andrew-Fiore Gartland Mich èle Tameris Simbarashe Mabwe Hadn Africa Nicole Bilek Fazlin Kafaar Shabaana A Khader Balie Carstens Katie Hadley Chris Hikuam M Source Type: research