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MicroRNA signature from extracellular vesicles of HCV/HIV co-infected individuals differs from HCV mono-infected
J Mol Med (Berl). 2023 Sep 14. doi: 10.1007/s00109-023-02367-8. Online ahead of print.ABSTRACTHepatitis C virus (HCV) coinfection with human immunodeficiency virus (HIV) has a detrimental impact on disease progression. Increasing evidence points to extracellular vesicles (EVs) as important players of the host-viral cross-talk. The microRNAs (miRNAs), as essential components of EVs cargo, are key regulators of normal cellular processes and also promote viral replication, viral pathogenesis, and disease progression. We aimed to characterize the plasma-derived EVs miRNA signature of chronic HCV infected and HIV coinfected pat...
Source: Molecular Medicine - September 13, 2023 Category: Molecular Biology Authors: Victoria Cairoli Daniel Valle-Millares Mar ía C Terrón-Orellano Daniel Luque Pablo Ryan Lourdes Dominguez Luz Mart ín-Carbonero Ignacio De Los Santos Elena De Matteo Beatriz Ameigeiras Ver ónica Briz Paola Casciato Mar ía Victoria Preciado Pamela Val Source Type: research

Insights into the mechanisms of telbivudine-induced myopathy associated with mitochondrial dysfunction
In conclusion, our study provides compelling evidence suggesting that telbivudine-induced myopathy is associated with mitochondrial toxicity and impaired energy metabolism. The observed muscle pathology, depletion of mtDNA, elevation of oxidative stress and altered mitochondrial function support the hypothesis that telbivudine disrupts mitochondrial homeostasis, ultimately leading to muscle damage. This may be also a common mechanism for NAs to cause neuromyopathy.PMID:37659625 | DOI:10.1016/j.cbi.2023.110692
Source: Chemico-Biological Interactions - September 2, 2023 Category: Molecular Biology Authors: Wenfei Yu Zhuxvn Li Wenjing Wu Dandan Zhao Chuanzhu Yan Pengfei Lin Source Type: research

Serum Expression Level of MicroRNA-122 and its Significance in different Stages of Hepatitis B Virus Infection
This study aims to determine the serum expression level of miRNA-122 and its significance in the different stages of Hepatitis B virus infection. The study subjects were recruited and grouped for Hepatitis B associated with Chronic Hepatitis B infection, hepatic sclerosis, hepatocellular carcinoma, and healthy controls were also considered. Venous blood was collected from the participants including the controls and routine blood tests and quantification of miRNA-122 were done and analyzed in each case of hepatitis B infection and compared with that of healthy controls. The miRNA-122 was determined, which came to be highest...
Source: Mol Biol Cell - August 22, 2023 Category: Molecular Biology Authors: Shashi Prabha Singh Vandana Maurya Krishan Kumar Durgesh Singh Poonam Verma Dipan Samanta Manish Kumar Verma Source Type: research

Optimization of a rapid and sensitive nucleic acid lateral flow biosensor for hepatitis B virus detection
CONCLUSION: In resource-limited settings, the LAMP-LF assay presents a promising solution for HBV testing. However, it is important to note that direct amplification without DNA purification may diminish the performance of the approach.PMID:37592176 | DOI:10.1007/s11033-023-08730-9
Source: Molecular Biology Reports - August 17, 2023 Category: Molecular Biology Authors: Abbas Ali Husseini Serap Yesilkir Baydar Source Type: research

Novel anti ‑hepatitis B virus flavonoids sakuranetin and velutin from < em > Rhus  retinorrhoea < /em >
In conclusion, the present study was the first to demonstrate the anti‑HBV therapeutic activities of SEK and VEL isolated from R. retinorrhoea.PMID:37539729 | DOI:10.3892/mmr.2023.13063
Source: Molecular Medicine - August 4, 2023 Category: Molecular Biology Authors: Sarfaraz Ahmed Mohammad K Parvez Mohammed S Al-Dosari Mazin A S Abdelwahid Tawfeq A Alhowiriny Adnan J Al-Rehaily Source Type: research

Analysis of hepatocellular carcinoma associated with hepatitis B virus
J Cell Mol Med. 2023 Jul 30. doi: 10.1111/jcmm.17867. Online ahead of print.ABSTRACTThe hepatitis B virus (HBV) is considered one of the main driving forces in the development of hepatocellular carcinoma (HCC). Human HBV is a partially double-stranded DNA (dsDNA) virus consisting of approximately 3.2 kbp. HBV predominantly infects hepatocytes via the receptor sodium taurocholate cotransporting polypeptide (NTCP) and coreceptor hepatic proteoglycan. The replication of HBV in hepatocytes leads to apoptosis while simultaneously leading to cirrhosis and cancer. Although the integration of dsDNA into the hepatocyte genome seems...
Source: J Cell Mol Med - July 30, 2023 Category: Molecular Biology Authors: Litao Zheng Source Type: research

Biomarkers of liver diseases
Mol Biol Rep. 2023 Jul 24. doi: 10.1007/s11033-023-08666-0. Online ahead of print.ABSTRACTThe liver is one of the pivotal organs in the human body and is fundamentally responsible for detoxification and metabolism. Various disorders such as non-alcoholic fatty liver disease, fibrosis, cirrhosis, hepatocellular carcinoma, and hepatitis are associated with improper functions of the liver. Hence, biomarkers are needed to determine the severity. Further, many liver enzymes, including the cascade of aspartate aminotransferase (AST)/serum glutamic oxaloacetic transaminase (SGOT), alanine aminotransferase (ALT)/serum glutamic pyr...
Source: Molecular Biology Reports - July 23, 2023 Category: Molecular Biology Authors: Sukhbir Singh Tamber Palak Bansal Suraj Sharma Rai Barinder Singh Ramica Sharma Source Type: research

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